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Cas Database

770-12-7

770-12-7

Identification

  • Product Name:Phenyl dichlorophosphate

  • CAS Number: 770-12-7

  • EINECS:212-220-6

  • Molecular Weight:210.984

  • Molecular Formula: C6H5Cl2O2P

  • HS Code:29209085

  • Mol File:770-12-7.mol

Synonyms:Phenylphosphorodichloridate (6CI);Dichlorophenoxyphosphineoxide;NSC 44412;Phenoxydichlorophosphine oxide;Phenoxyphosphoryl dichloride;Phosphorodichloridic acid, phenyl ester;Phenylphosphoricdichloride;

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Safety information and MSDS view more

  • Pictogram(s):CorrosiveC

  • Hazard Codes:C

  • Signal Word:Danger

  • Hazard Statement:H314 Causes severe skin burns and eye damage

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

  • Fire-fighting measures: Suitable extinguishing media Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016) Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:Usbiological
  • Product Description:Phenyl Dichlorophosphate
  • Packaging:25g
  • Price:$ 333
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:Phenyl dichlorophosphate
  • Packaging:500g
  • Price:$ 410
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Phenyl Dichlorophosphate >98.0%(GC)(T)
  • Packaging:25g
  • Price:$ 16
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Phenyl Dichlorophosphate >98.0%(GC)(T)
  • Packaging:500g
  • Price:$ 226
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Phenyl dichlorophosphate 97%
  • Packaging:1 kg
  • Price:$ 224
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Phenyl dichlorophosphate ≥95%
  • Packaging:25g
  • Price:$ 27.7
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Phenyl dichlorophosphate ≥95%
  • Packaging:100g
  • Price:$ 93.1
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  • Manufacture/Brand:Oakwood
  • Product Description:Phenyl phosphorodichloridate
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  • Manufacture/Brand:Oakwood
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  • Manufacture/Brand:Oakwood
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Relevant articles and documentsAll total 53 Articles be found

Prodrug compound and application ofprodrug compound in treatment of cancer

-

Paragraph 0140-0141, (2021/03/06)

The present invention provides a compound indicated by a formula (I), pharmaceutically acceptable salts or esters thereof, a pharmaceutical composition of the compound, and application of the compoundand the pharmaceutical composition in the inhibition or regulation of the activity of tyrosine kinase and treating disease symptoms or symptoms including cancer mediated by tyrosine kinase.

PRODRUGS OF THE TYROSINE KINASE INHIBITOR FOR TREATING CANCER

-

Paragraph 00101-00102, (2021/03/05)

There are provided compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, useful for inhibition or modulation of the activity of tyrosine kinases and treatment of disease states or conditions mediated by tyrosine kinases, including cancers. (I)

Organophosphorous phenyl phosphates: Synthesis, dye/protein interactions and antimicrobial evaluation

Ameta, Rakesh Kumar,Duan, Yongtao,Koshti, Rohit R.,Muddassir, Mohd.,Patel, Amee S.,Trivedi, Nidhi S.,Vyas, Akshay

, (2021/01/09)

A series of Phenyl Phosphates (PPs) has been synthesized and characterized with FTIR spectroscopy. PPs, the product of the reaction of phenol and phosphoryl chloride followed by hydrolysis having larger number of hydrophilic hydroxyl groups, used for the dye interaction and antimicrobial activities. Interaction of PPs with 1,2-diphenyldiazene and 4-(phenyldiazene)phenol were studied through UV/ Vis method where observed hypochromic effect has revealed the dye adsorption property of PPs. Similarly PPs have shown the interaction with bovine serum and human serum albumins where the weaker interaction observed with later. Antimicrobial in vitro evaluation has been assessed on the basis of zone of inhibition with six bacterial (gram +ve and –ve) strains. Since PPs were found very active so minimal inhibitory concentration (MIC) analysis was done where all PPs have shown MIC less than 5 μg/mL. Due to high number of hydroxyl groups PPs have shown good interactions with biomolecules and cell wall of bacteria therefore this impression has predicted their future in medicinal field.

BI- AND MONOCYCLIC NUCLEOSIDE ANALOGS FOR TREATMENT OF HEPATITIS E

-

Page/Page column 35; 43, (2021/10/22)

The present disclosure is directed toward bi- and monocyclic nucleoside analogs, and compositions comprising these compounds for use in the treatment of hepatitis E infections.

Preparation method of pentaerythritol diphosphate

-

Paragraph 0032; 0044-0045; 0047-0048; 0050-0051, (2020/09/12)

The invention relates to the technical field of organic synthesis, and provides a preparation method of pentaerythritol diphosphate. The phosphoryl dichloride compound is prepared from a phenolic compound and phosphorus oxychloride under the condition of a catalyst, the yield of the phosphoryl dichloride compound is high, the activity of the phosphoryl dichloride compound is high, and the next step of reaction can be directly carried out without drying; then the phosphoryl dichloride compound is reactd with pentaerythritol under the vacuum pressure reduction condition, acid generated in the reaction can be rapidly removed under the vacuum pressure reduction condition, and the reaction can be carried out in the forward direction; furthermore, a phosphoryl dichloride compound is dropwise added, after dropwise adding is completed, esterification can be completed basically by one acyl chloride, and at the moment, an acid-binding agent is added, so that esterification of a second acyl chloride is facilitated, and the reaction time is greatly shortened; and the reaction temperature can be reduced under the vacuum decompression condition, the problems of acidolysis of pentaerythritol diphosphate and reaction with hydrogen chloride are avoided, the reaction safety and operability are improved, and the reaction efficiency is improved.

Process route upstream and downstream products

Process route

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

Conditions
Conditions Yield
With magnesium chloride; trichlorophosphate; In xylene; at 90 - 110 ℃; Kinetics; Product distribution; Rate constant;
With trichlorophosphate; at 102 - 240 ℃;
phosphorus trichloride
7719-12-2,52843-90-0

phosphorus trichloride

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

Conditions
Conditions Yield
at 140 ℃;
O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

Conditions
Conditions Yield
With triethylamine; trichlorophosphate; In tert-butyl methyl ether; at -55 - 20 ℃; for 4h;
98%
With magnesium chloride; trichlorophosphate; at 80 - 95 ℃; for 5h; Large scale;
91.5%
With triethylamine; trichlorophosphate; In diethyl ether; at -78 - 20 ℃; Inert atmosphere;
85%
With triethylamine; trichlorophosphate; In diethyl ether; at -78 - 20 ℃;
85%
With sodium chloride; phosphorus trichloride;
80%
With sodium chloride; trichlorophosphate; for 6h; Heating;
74.1%
With trichlorophosphate;
70.1%
With potassium chloride; trichlorophosphate;
With aluminium trichloride; trichlorophosphate;
With trichlorophosphate; at 125 - 130 ℃;
With magnesium chloride; trichlorophosphate; at 110 - 120 ℃;
With trichlorophosphate;
With triethylamine; trichlorophosphate; In diethyl ether; 1.) from 0 deg C to RT, 15 h, 2.) reflux, 2h;
With triethylamine; trichlorophosphate; In tetrahydrofuran; Ambient temperature;
With triethylamine; trichlorophosphate; In diethyl ether;
With triethylamine; trichlorophosphate; In benzene; Heating;
With triethylamine; trichlorophosphate; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;
With triethylamine; trichlorophosphate; In diethyl ether;
With triethylamine; trichlorophosphate; In dichloromethane; at -50 - 20 ℃;
With triethylamine; trichlorophosphate; In diethyl ether; at -78 ℃;
With trichlorophosphate;
With triethylamine; trichlorophosphate; In diethyl ether; at -78 - 20 ℃;
With triethylamine; trichlorophosphate; In diethyl ether; at -78 - 20 ℃; Protection from moisture;
With triethylamine; trichlorophosphate; In diethyl ether; at -78 - 20 ℃; for 20h; Inert atmosphere;
With aluminum (III) chloride; trichlorophosphate; In hexane; for 0.5h; Reflux;
With trichlorophosphate;
With triethylamine; trichlorophosphate; In diethyl ether; for 1h; Inert atmosphere; Cooling with liquid nitrogen;
With pyridine; trichlorophosphate; In benzene; for 1h; Reflux;
With pyridine; trichlorophosphate; In benzene; for 1h; Reflux;
With triethylamine; trichlorophosphate; In diethyl ether; at -78 - 20 ℃; for 20h; Inert atmosphere;
With triethylamine; trichlorophosphate; In dichloromethane; at -78 - 20 ℃; for 2h;
With triethylamine; trichlorophosphate; In dichloromethane; at -78 - 20 ℃;
With triethylamine; trichlorophosphate; In diethyl ether; at -70 - 20 ℃; for 18h; Inert atmosphere;
With triethylamine; trichlorophosphate; In dichloromethane; at -78 - 20 ℃; for 2h; pH=3 - 4;
With triethylamine; trichlorophosphate; In dichloromethane; at -78 - 20 ℃; for 2h;
phenol; With N-ethyl-N,N-diisopropylamine; In ethanol; at 20 ℃; for 0.25h;
With trichlorophosphate; In ethanol; at -78 - 20 ℃; for 1.5h;
With triethylamine; trichlorophosphate; In dichloromethane; at -60 - 25 ℃; for 2h;
With triethylamine; trichlorophosphate; In diethyl ether; at -78 ℃;
phenol; With n-butyllithium; In tetrahydrofuran; diethyl ether; at -30 ℃; for 0.166667h; Inert atmosphere;
With trichlorophosphate; In tetrahydrofuran; diethyl ether; at 20 ℃; Inert atmosphere;
With triethylamine; trichlorophosphate; In dichloromethane; at -78 - 20 ℃; for 2h;
With triethylamine; trichlorophosphate; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;
With iron; trichlorophosphate;
With triethylamine; trichlorophosphate; In diethyl ether; at 0 ℃; for 3h; Inert atmosphere;
800 g
With triethylamine; trichlorophosphate; In diethyl ether; at -78 - 20 ℃; for 2h; Inert atmosphere;
With triethylamine; trichlorophosphate; In dichloromethane; at -70 - 20 ℃; for 2h; Time;
With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; at -78 - 20 ℃; for 2.5h; Inert atmosphere;
With trichlorophosphate; at 130 - 134 ℃; for 10h;
With triethylamine; trichlorophosphate; In dichloromethane; at -70 - 20 ℃; for 1h;
phenyl phosphorodichloridite
3426-89-9

phenyl phosphorodichloridite

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

Conditions
Conditions Yield
With ozone; In dichloromethane; at 0 ℃;
99%
Phenylchlorophosphonic Acid Phenyl Ester
61274-57-5

Phenylchlorophosphonic Acid Phenyl Ester

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

Conditions
Conditions Yield
With titanium tetrachloride; trichlorophosphate; at 70 - 90 ℃; Reagent/catalyst; Temperature; Overall yield = 95 %;
tetrachlorophenoxyphosphorane
19579-04-5

tetrachlorophenoxyphosphorane

ethyl vinyl ether
109-92-2,25104-37-4

ethyl vinyl ether

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

phenyl (2-ethoxyvinyl)-phosphonochloridate

phenyl (2-ethoxyvinyl)-phosphonochloridate

Conditions
Conditions Yield
With sulfur dioxide; In benzene; at 0 - 5 ℃;
67.1%
32.5%
sodium phenoxide
139-02-6

sodium phenoxide

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

Conditions
Conditions Yield
With tetrabutylammomium bromide; trichlorophosphate; In toluene; for 1h;
90%
diethyl amine hydrochloride
660-68-4

diethyl amine hydrochloride

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

Conditions
Conditions Yield
With trichlorophosphate;
O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

Conditions
Conditions Yield
With triethylamine; In diethyl ether; at 0 ℃; for 0.5h; Yield given;
O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

Conditions
Conditions Yield
With phosphorus pentachloride;

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