824-72-6Relevant articles and documents
MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES
-
, (2018/06/06)
The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices, which comprise these compounds.
Selective Substitution of POCl 3 with Organometallic Reagents: Synthesis of Phosphinates and Phosphonates
Verbelen, Bram,Dehaen, Wim,Binnemans, Koen
, p. 2019 - 2026 (2018/04/14)
The selectivity of the substitution reaction of phosphoryl chloride with organometallic reagents was investigated using NMR spectroscopy. This led to the discovery that the selectivity of the substitution reaction can be tuned by choosing a proper organometallic reagent. A phosphinate could be obtained by using a Grignard reagent whereas an organozinc reagent provided a phosphonate. Based on these results, one-pot synthetic methods for the preparation of phosphinates and phosphonates using commercially available starting materials were developed. Both methods allow the synthesis of a broad range of either phosphinate or phosphonate derivatives in a straightforward and general procedure. Moreover, using these one-pot procedures, mixed systems substituted with different alkyl/aryl groups can be prepared.
New method for synthesizing substituted phosphinate
-
Paragraph 0032-0034, (2017/12/27)
The invention discloses a new method for synthesizing substituted phosphinate. The method comprises the step of generating the substituted phosphinate by reducing halogenated phosphonate under the effect of a reducing agent. The optimal preparation method for the substituted phosphinate is screened through a large number of experiments according to the invention; the whole process is reasonably designed; the technological operation is simple and efficient; especially, the optimal reaction conditions are screened, including reaction solvent, reaction temperature, reaction time and optimal reaction pH value; the reaction yield is obviously increased; the yield reaches up to 85-95%; the side reaction is less; the production cost is greatly lowered; the industrial production can be realized; and the method has a wide application prospect.
Cyclic Phosphine Oxides and Phosphinamides from Di-Grignard Reagents and Phosphonic Dichlorides: Modular Access to Annulated Phospholanes
Gregson, Aaron M.,Wales, Steven M.,Bailey, Stephen J.,Willis, Anthony C.,Keller, Paul A.
, p. 9774 - 9780 (2015/10/12)
The reaction between 1,4-di-Grignard reagents and phosphonous(III) dichlorides is a classical method for the direct synthesis of phospholanes. Reported here is an extension of this approach to the preparation of value-added, annulated phospholane oxides, achieved through the combination of carbocyclic-fused di-Grignard reagents and readily available phosphonic(V) dichlorides. The procedure is amenable to (benz)annulation at both the 2,3- and 3,4-positions of the phospholane ring, and a variety of aliphatic, cyclic and aryl P-electrophiles are tolerated in reasonable to excellent yields.
Anti-cocaine catalytic antibody
-
, (2008/06/13)
Disclosed are catalytic antibodies and polypeptides capable of degrading cocaine. Said catalytic antibodies and polypeptides are characterized by the amino acid sequence of their complementary determining regions and framework regions. The present invention also discloses a pharmaceutical composition and a method for decreasing the concentration and a method for decreasing the concentration of cocaine of a subject. Finally, the invention discloses pharmaceutical compositions and methods for treating cocaine overdose and addiction in subjects.
The mechanism of thionyl chloride reaction with dialkyl alkylphosphonothionate using 31P NMR
Purnanand,Shakya,Saxena, Shefali,Sharma,Lal, Basant
, p. 1093 - 1099 (2007/10/03)
Based on 31P NMR studies of thionyl chloride reaction with dialkyl alkylphosphonothionates, a method for preparation of alkylphosphonic dichloride has been investigated. A mechanism via intermediacy of ester chloride is suggested.
Studies on chiral thiophosphoric acids and their derivatives 16. - The asymmetric cyclization of L-(+)-prolinol with (thio)phosphoro(-no)dichloridates
He, Zheng-Jie,Wang, You-Ming,Tang, Chu-Chi
, p. 59 - 66 (2007/10/03)
The cyclizations of L-(+)-prolinol 5 with (thio)phosphoro(-no)dichloridates 6 give 1,2,3-azaphosphaoxabicyclo[3.3.0]octanes 7 consisting of unequal amounts of diastereoisomers, eight pairs of which have been successfully resolved by silica gel column chromatography or recrystallization. The influences of reaction temperature, solvent and substrate concentration upon the asymmetric induction have also been investigated.
Reactions of aryltetrachlorophosphoranes with sodium dithionite and sulfuryl chloride
Mitrasov,Anisimova,Kormachev
, p. 765 - 766 (2007/10/03)
Reaction of aryltetrachlorophosphoranes with sodium dithionite or sulfuryl chloride leads to dichloroanhydrides of arylphosphonic acids in high yields. 1996 MAEe cyrillic signK Hayκa/Interperiodica Publishing.
A general synthesis of phosphonic acid dichlorides using oxalyl chloride and DMF catalysis
Rogers, Roland S.
, p. 7473 - 7474 (2007/10/02)
A general synthesis of phosphonic diacid dichlorides (1) using oxalyl chloride and catalytic DMF is described.
