112-60-7Relevant articles and documents
Photocatalytic Degradation of Hexaethylene Glycol
Simangoye Ngobissi, Drocilia Ednah,Soufi, Jihène,Vanoye, Laurent,Richard, Dominique
, p. 1608 - 1614 (2017/08/29)
Abstract: Polyethylene glycol (PEG) photodegradation was studied in water under UV irradiation in the presence of catalytic amount of TiO2 using hexaethylene glycol as a model compound. Full conversion was achieved in 7 h with an average quantum yield around 1%. Formic acid was found to be the main intermediate and was slower to oxidize into CO2 (traces remains after 24 h). The other intermediates [lower PEG, oxidized PEG (formates, aldehydes and acids, acetic acid)] of the photodegradation have also been identified and quantified. A mechanism based on previous literature but also taking into account these new observations is proposed. Graphical Abstract: [Figure not available: see fulltext.].
Lipid carrier
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, (2008/06/13)
The invention refers to a lipid carrier composition for controlled release of a bioactive substance, which comprises at least one triglyceride oil, and at least one polar lipid selected from the group consisting of phosphatidylethanolamine and monohexosylceramide, and ethanol, which is characterised in that the carrier composition has the ability to form a cohesive structure, which structure is retained in an aqueous environment. The invention also refers to a pharmaceutical composition consisting of said lipid carrier and a bioactive substance dissolved or dispersed in the carrier, preferably an injectable composition.
Valency platform molecules comprising carbamate linkages
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, (2008/06/13)
This invention pertains generally to valency molecules, such as valency platform molecules which act as scaffolds to which one or more molecules may be covalently tethered to form a conjugate. More particularly, the present invention pertains to valency platform molecules which comprise a carbamate linkage (i.e., —O—C(=O)—N). In one aspect, the present invention pertains to valency platforms comprising carbamate linkages, which molecules have the structure of any one of Formulae I, II, or III, shown in FIG. 1. In one aspect, the present invention pertains to valency platforms comprising carbamate linkages, which molecules have the structure of any one of Formulae IV, V, or VI, shown in FIG. 8. The present invention also pertains to methods of preparing such valency platform molecules, conjugates comprising such valency platform molecules, and methods of preparing such conjugates.
Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents
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, (2008/06/13)
Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine, trihydroxy steroids, and flurbiprofen molecules linked to polyethylene glycol (PEG) groups. Pharmaceutical compositions containing these prodrugs, and a method of using these esters for treating disease states or symptoms are also described.
Method for blood coagulation on hard tissues
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, (2008/06/13)
A method of using resorbable waxes for coagulation of blood on endogenous hard tissue, especially bone, which waxes consist of waxy polyester-oligomers of hydroxybarboxylic acids which are viscous to solid at body temperature. On the basis of their structure, these waxes are degradable by endogenous metabolic mechanism, wherein the rate of degradation can be adjusted.
Relaxation Kinetics and Infrared Spectra of the Complexation of Lithium Ion by Triethylene Glycol and by Tetraethylene Glycol in Acetonitrile
Cobranchi, Daryl P.,Garland, Ben A.,Masiker, Marilyn C.,Eyring, Edward M.,Firman, Paul,Petrucci, Sergio
, p. 5856 - 5865 (2007/10/02)
Ultrasonic absorption relaxation spectra are reported covering the frequency range ca. 1-500 MHz for the complexation of LiClO4 by the open-chain polyethers triethylene glycol (EG3) and tetraethylene glycol (EG4) in acetonitrile at 25 deg C and at a molar ratio R = / or R = / = 1.The ultrasonic spectra can be described by the sum of two Debye relaxation processes which were interpreted according to the Eigen-Winkler mechanism Li+ + EG Li+...EG Li+EG (Li+EG) (where EG denotes either EG3 or EG4), giving the rateconstants k1, k-1, k2, and k-2.The first step is taken to be a preequilibrium step for which K0 is calculated from classical statistical theory.The rate constants are compared with those of the corresponding process involving triglyme and poly(ethylene oxide) (PEO) previously reported.Infrared data for the 3800-3200-cm-1 region show a shift of 70 cm-1 to lower energy, indicating a strong interaction between the ethanolic oxygen of EG3 and the Li+ ion.
Production of polyalkylene glycol ethers
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, (2008/06/13)
Mono-alkyl or alkylene ethers of polyalkylene glycols are produced by reacting them with an aldehyde to form an adduct and hydrogenating the adduct.
The Influence of Cation Binding on the Kinetics of the Hydrolysis of Crown Ether Acetals
Baker, David S.,Gold, Victor,Sghibartz, Cristian M.
, p. 1121 - 1128 (2007/10/02)
The rate of hydrogen ion-catalysed hydrolysis of crown ether acetals in 60:40 (v/v) dioxan-water is found to be strongly decreased by the addition of alkali and alkaline earth metal chlorides having cations of appropriate size to be complexed by the substrate ring.The compounds studied are the monoacetals CH3CH(OCH2CH2)xO with x=1-8.The dependence of the initial rate of formation of acetaldehyde on metal-ion concentration is expressed in terms of (i) the equilibrium constant for complex formation, (ii) the influence of the bound cation on the rate constant, and (iii) an electrolyte effect.A curve-fitting procedure is used to derive the parameters governing the first two of these effects.The equilibrium constants are large and cannot be evaluated with any precision, but a fair estimate of the influence of the guest cation on the rate can be obtained.This effect is explicable by the electrostatic repulsion between the cationic charges of the metal ion and the proton added to the acetal in the first step of the hydrolysis.The size of the effect requires the values of the effective relative permittivity of the space between the charges to be close to that of the bulk solvent.
The Synthesis of Adrenaline Crown Ethers
Fenton, David E.,Parkin, Donald,Newton, Roger F.
, p. 449 - 454 (2007/10/02)
The syntheses of adrenaline-15-crown-5 and adrenaline-18-crown-6 starting from acetovanillone are reported, together with the properties of these compounds.Alkali and alkaline-earth metal complexes of these ligands have been prepared.A method of separating crown ethers based on their preferential complexation of barium is discussed.
