116-16-5 Usage
Description
Hexachloroacetone, also known as hexachloro-2-propanone, is a yellow-colored liquid that is slightly soluble in water and denser than water. It has a clear colorless to yellowish appearance and its vapors are much heavier than air. Hexachloroacetone is known to irritate skin and eyes and may be toxic by ingestion or inhalation. It is primarily used to make other chemicals.
Uses
Used in Polymerization Industry:
Hexachloroacetone is used as a reagent for the polymerization of vinyl compounds, facilitating the process of creating polymers from vinyl monomers.
Used in Pharmaceutical Industry:
Hexachloroacetone is used for the conversion of nucleoside-3′-phosphonates to the corresponding phosphates, which is an important step in the synthesis of certain pharmaceutical compounds.
Used in Chemical Synthesis:
Hexachloroacetone is used in the synthesis of chirally deuterated benzyl chlorides and enol phosphate 2,2-dichloro-1-(trichloromethyl)ethenyl diethyl phosphate, contributing to the development of specific chemical compounds.
Used in Peptide Synthesis:
Hexachloroacetone is used in obtaining efficient amino acid activation by exploiting the rapid formation of acid chlorides under low temperature and acid/base free conditions, which is beneficial in the synthesis of peptides and other biomolecules.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
Hexachloroacetone is a halogenated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
Hazard
Toxic by ingestion and inhalation, strong
irritant. Combustible. Evolves phosgene when
heated.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Check Digit Verification of cas no
The CAS Registry Mumber 116-16-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 6 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 116-16:
(5*1)+(4*1)+(3*6)+(2*1)+(1*6)=35
35 % 10 = 5
So 116-16-5 is a valid CAS Registry Number.
116-16-5Relevant articles and documents
A critical examination of the preparation of polychlorinated acetones
Foehlisch, Baidur,Zinser, Hartmut
, p. 549 - 572 (2004)
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Nitrile Sulphides. Part 3. Thermal Fragmentation of 1,3,4-Oxathiazoles: Formation of Nitrile Sulphides in a Retro-1,3-dipolar Cycloaddition Reaction
Paton, R. Michael,Robertson, Fiona M.,Ross, John F.,Crosby, John
, p. 1517 - 1522 (2007/10/02)
On thermolysis at ca. 160 gradC 1,3,4-oxathiazoles undergo retro-1,3-dipolar cycloaddition forming nitrile sulphides and carbonyl-containing fragments.The nitrile sulphides either decompose to sulphur and nitriles or are trapped as their 1,3-dipolar cycloadducts in the presence of dipolarophiles (dimethyl acetylenedicarboxylate, ethyl cyanoformate, benzonitrile, ethyl propiolate).Similar ratios (1.32, l.34, 1.33, 1.31) of 4- and 5-ethoxycarbonyl-3-(p-methoxyphenyl)isothiazole obtained from four sources of p-methoxybenzonitrile sulphide with ethyl propriolate provide strong evidence for product formation from a discrete intermediate nitrile sulphide rather than via direct interaction of precursor with dipolarophile. 2-Dichloromethylene-1,3,4-oxathiazoles, prepared by dehydrochlorination of 2-trichloromethyloxathiazoles, prepared by dehydrochlorination of 2-trichlorometyloxathiazoles, likewise fragment to nitrile sulphides, but attempts to trap dichloroketene were unsuccessful.
Nitrile Sulphide Formation from the Thermal Fragmentation of 1,3,4-Oxathiazoles: a Retro-1,3-dipolar Cycloaddition
Paton, R. Michael,Robertson, Fiona M.,Ross, John F.,Crosby, John
, p. 714 - 715 (2007/10/02)
1,3,4-Oxathiazoles, on thermolysis, undergo retro-1,3-dipolar cycloaddition to afford carbonyl compounds and nitrile sulphides, which may be trapped by cycloaddition with alkynes and nitriles.