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Cas Database

18162-48-6

18162-48-6

Identification

  • Product Name:Silane,chloro(1,1-dimethylethyl)dimethyl-

  • CAS Number: 18162-48-6

  • EINECS:242-042-4

  • Molecular Weight:150.724

  • Molecular Formula: C6H15ClSi

  • HS Code:29310095

  • Mol File:18162-48-6.mol

Synonyms:Silane,chloro-tert-butyldimethyl- (8CI);(1,1-Dimethylethyl)dimethylsilyl chloride;Chloro-tert-butyldimethylsilane;Dimethyl(1,1-dimethylethyl)chlorosilane;Dimethyl-tert-butylsilyl chloride;TBDMS chloride;TBDMS-Cl;t-Butyldimethylchlorosilane;tert-Butyl(dimethyl)silane chloride;tert-Butyldimethylchlorosilane;Tert-butyldimethylsilyl chloride ( TBMS );T-Butyldimethylsilyl chloride;tert-Butyldimethylsilyl chloride;

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Safety information and MSDS view more

  • Pictogram(s):CorrosiveC,FlammableF,ToxicT

  • Hazard Codes:C,F,T,Xn

  • Signal Word:No signal word.

  • Hazard Statement:none

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
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  • Manufacture/Brand:TRC
  • Product Description:tert-Butyldimethylsilyl chloride
  • Packaging:25g
  • Price:$ 85
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent] >98.0%(GC)
  • Packaging:100g
  • Price:$ 137
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent] >98.0%(GC)
  • Packaging:25g
  • Price:$ 72
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent] >98.0%(GC)
  • Packaging:5g
  • Price:$ 23
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:tert-Butyldimethylchlorosilane, 50% in toluene
  • Packaging:5 g
  • Price:$ 30
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:tert-Butyldimethylchlorosilane 98%
  • Packaging:250 g
  • Price:$ 35
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:tert-Butyldimethylchlorosilane, 50% in toluene
  • Packaging:25 g
  • Price:$ 45
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:tert-Butyldimethylchlorosilane 98%
  • Packaging:50 g
  • Price:$ 13
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:tert-Butyldimethylchlorosilane, 50% in toluene
  • Packaging:100 g
  • Price:$ 75
  • Delivery:In stock
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  • Manufacture/Brand:Strem Chemicals
  • Product Description:t-Butyldimethylchlorosilane, min. 97%
  • Packaging:10g
  • Price:$ 46
  • Delivery:In stock
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Relevant articles and documentsAll total 26 Articles be found

The recycling of organosilyl protecting species used in organic synthesis and the water binding ability of the silanol tBuMe2SiOH

Lickiss, Paul D.,Stubbs, Katharine M.

, p. 171 - 174 (1991)

The silanols formed on the cleavage of organosilyl protecting groups from organic compounds can be efficiently reconverted into the chlorosilanes used in the initial silylation reaction by treatment with SOCl2.The silanol tBuMe2SiOH is very readily removed from organic reaction mixtures as its remarkably volatile hemihydrate tBuMe2SiOH>2 * H2O.

First gas-phase generation of a cis chloroiminoarsane ClAs NSiMe and a cis chloroiminophosphane ClP NSiMe Bu. Characterization by photoelectron spectroscopy

Miqueu,Sotiropoulos,Pfister-Guillouzo,Romanenko

, p. 930 - 938 (2001)

Photoelectron spectroscopy-flash vacuum thermolysis in the gas phase allowed us to synthesize, for the first time, the cis forms of two weakly hindered, low-coordinate arsenic and phosphorus compounds (ClPn NSiR3; Pn = P, As), as well as to characterize them by their ionization energies. In order to assign the different bands in the PE spectra and to estimate the effect of the substituents SiMe3 and Cl on the electronic and structural properties of these compounds, we performed calculations using density functional theory (hybrid functional B3LYP) with the basis set 6-311G(d,p). The thermodynamic stabilization of these halogenated systems appears in the important antiperiplanar interactions between the nitrogen lone pair nNand the σ*AsCl (or σ*PCl) orbital. For these two compounds, in spite of a poor 2pπ(N)-3pπ(P)/4pπ(As) overlap, it was observed that the substitution of a chlorine atom on the pnictogen (As,P) and a silyl group on nitrogen (negative hyperconjugation) leads to a relatively high ionization energy for the πPn N orbital [IE(πPn N ≈ 10 eV].

Oxidation of Triorganosilanes and Related Compounds by Chlorine Dioxide

Grabovskiy, S. A.,Kabal’nova, N. N.

, p. 2391 - 2402 (2022/01/22)

Abstract: Oxidation of triethylsilane, tert-butyldimethylsilane, dimethylphenylsilane, triphenylsilane, 1,1,1,2tetramethyl-2-phenyldisilane, tris(trimethylsilyl)silane, hexamethyldisilane, tetrakis(trimethylsilyl)silane, 1,1,3,3tetraisopropyldisiloxane with chlorine dioxide was carried out. The reaction products of studied triorganosilanes with chlorine dioxide in an acetonitrile solution were the corresponding silanols and siloxanes. A mechanism explaining the formation of products and the observed regularities of the oxidation of silanes with chlorine dioxide has been proposed. A thermochemical analysis of some possible pathways in the gas phase using methods G4, G3, M05, and in an acetonitrile solution by the SMD-M05 method was carried out. The oxidation process can occur both with the participation of ionic and radical intermediates, depending on the structure of the oxidized substrate and medium.

Hexachloroethane: a highly efficient reagent for the synthesis of chlorosilanes from hydrosilanes

Pongkittiphan, Veerachai,Theodorakis, Emmanuel A.,Chavasiri, Warinthorn

scheme or table, p. 5080 - 5082 (2009/12/01)

A new and efficient chlorination protocol is presented for the preparation of chlorosilanes from hydrosilanes. A variety of chlorinating agents in combination with palladium(II) chloride as the catalyst are examined. Among them, hexachloroethane is found to be the best choice, furnishing the desired product in good to quantitative yields under mild conditions. Various hydrosilanes are used as starting materials to explore the scope of this reaction.

The synthesis of chlorosilanes from alkoxysilanes, silanols, and hydrosilanes with bulky substituents

Masaoka, Shin,Banno, Tadashi,Ishikawa, Mitsuo

, p. 174 - 181 (2007/10/03)

We have found that commercially important trialkylchlorosilanes can readily be synthesized by the reaction of alkoxysilanes, silanols, and hydrosilanes with aqueous concentrated hydorochloric acid. Treatment of trialkylalkoxysilanes bearing the bulky alkyl substituents, such as the i-Pr, sec-Bu, tert-Bu, and cyclo-Hex group, with 35% aqueous hydrochloric acid afforded the corresponding trialkylchlorosilanes in excellent yields. Similar treatment of trialkylsilanols with 35% aqueous hydrochloric acid also gave trialkylchlorosilanes in almost quantitative yields. The reaction of methyltrichlorosilane and dimethyldichlorosilane with alkyl-Grignard reagents bearing a bulky alkyl group, followed by treatment of the resulting mixtures with aqueous concentrated hydrochloric acid, produced the respective dialkylmethyl- and alkyldimethylchlorosilanes in high yields. Treatment of trialkylhydrosilanes with concentrated hydrochloric acid in the presence of a palladium catalyst afforded trialkylchlorosilanes in high yields.

Production processes for triorganomonoalkoxysilanes and triorganomonochlorosilanes

-

Page/Page column 27, (2008/06/13)

A silane containing a bulky hydrocarbon group or groups R therein and having the formula (III) [in-line-formulae]R3-(x+y)(R1)x(R2)ySi(OR3) [/in-line-formulae] can be produced by reacting a silane of the formula (I) [in-line-formulae](R1)x(R2) ySiCl3-(x+y)(OR3) [/in-line-formulae] with a Grignard reagent of the formula (II) [in-line-formulae]RMgX [/in-line-formulae] Further, a tri-organo-chlorosilane of the formula (XIIa) [in-line-formulae](R1)(R2)(R3)SiCl [/in-line-formulae] can be produced by reacting a tri-organo-silane of the formula (XIa) [in-line-formulae](R1)(R2)(R3)SiZ1 [/in-line-formulae] with hydrochloric acid. Furthermore, a tri-organo-monoalkoxysilane of the formula (XXIII) [in-line-formulae]R3-(x+y)(R1)x(R2)ySi(OR3) [/in-line-formulae] can be produced when a silane of the formula (XXI) [in-line-formulae](R1)x(R2)ySiCl4-(x+y) [/in-line-formulae] is reacted with a Grignard reagent of the formula (XXII) [in-line-formulae]RMgX [/in-line-formulae] with addition of and reaction with an alcohol or an epoxy compound during the reaction.

Selective synthesis of halosilanes from hydrosilanes and utilization for organic synthesis

Kunai, Atsutaka,Ohshita, Joji

, p. 3 - 15 (2007/10/03)

Selective synthesis of halosilanes has been examined. Various types of halosilanes and halohydrosilanes, such as R3SiX, R2SiHX, R2SiX2, RSiH2X, RSiHX2 (X=Cl, Br, F), were obtained by the reactions of the corresponding hydrosilanes with Cu(II)-based reagents selectively in high yields. This method could be also applied to the synthesis of chlorofluorosilanes and chlorohydrogermanes. On the other hand, iodo- and bromosilanes and germanes were obtained by Pd- or Ni-catalyzed hydride-halogen exchange reactions of hydrosilanes with alkyl or allyl halides. Their synthetic applications have been demonstrated by using iodo- and bromosilanes and chlorofluorosilanes.

Process route upstream and downstream products

Process route

tert.-butyl lithium
594-19-4

tert.-butyl lithium

dimethylsilicon dichloride
75-78-5,30107-43-8

dimethylsilicon dichloride

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

Conditions
Conditions Yield
In pentane; for 2h; Heating;
61%
In pentane;
In hexane;
tert-butyldimethylfluorosilane
2357-76-8

tert-butyldimethylfluorosilane

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

Conditions
Conditions Yield
With chloro-trimethyl-silane; aluminium trichloride;
tert-butyldimethylsilanol
18173-64-3

tert-butyldimethylsilanol

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

Conditions
Conditions Yield
With thionyl chloride; In chloroform; for 0.5h;
39%
With hydrogenchloride; In hexane; at 0 ℃; for 2h;
98 % Chromat.
tert-butyldimethylsilane
29681-57-0

tert-butyldimethylsilane

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

Conditions
Conditions Yield
With hexachloroethane; palladium dichloride; In tetrahydrofuran; at 20 ℃; for 2h;
89%
With tetrabutylammonium perchlorate; copper(l) chloride; In 1,2-dimethoxyethane; electrochemical reaction;
83%
With copper(l) iodide; copper dichloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 60h;
73%
1-(tert-butyldimethylsilyloxy)-1-isopropoxycyclopropane
96760-01-9

1-(tert-butyldimethylsilyloxy)-1-isopropoxycyclopropane

isopropyl chloride
75-29-6

isopropyl chloride

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

isopropyl 3-(trichlorotitanio)propionate

isopropyl 3-(trichlorotitanio)propionate

C<sub>9</sub>H<sub>19</sub>Cl<sub>3</sub>O<sub>2</sub>SiTi

C9H19Cl3O2SiTi

Conditions
Conditions Yield
With titanium tetrachloride; In chloroform-d1; Product distribution; Mechanism;
tert-butyl(dimethyl)(phenylseleno)silane
72726-46-6

tert-butyl(dimethyl)(phenylseleno)silane

diphenyl diselenide
1666-13-3

diphenyl diselenide

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

Conditions
Conditions Yield
With chlorine; In tetrachloromethane;
96%
93%
tertiary butyl chloride
507-20-0

tertiary butyl chloride

dimethylsilicon dichloride
75-78-5,30107-43-8

dimethylsilicon dichloride

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

Conditions
Conditions Yield
With magnesium; In tetrahydrofuran; hexane;
78%
With copper(l) cyanide; magnesium; In tetrahydrofuran; for 2h; Heating;
74%
di(methyl)tert-butyl(methoxy)silane
66548-21-8

di(methyl)tert-butyl(methoxy)silane

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

Conditions
Conditions Yield
With hydrogenchloride; In water; at 20 ℃; for 10h;
78%
With hydrogenchloride; In hexane; at 0 ℃; for 2h;
71%
With hydrogenchloride; In water; at 20 ℃; for 5 - 10h; Product distribution / selectivity;
60%
tri-t-butylsilane
18159-55-2

tri-t-butylsilane

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

Conditions
Conditions Yield
With hydrogenchloride; palladium on activated charcoal; In hexane; at 25 ℃; for 2h;
87%
Aminodichlorphosphan
85909-11-1

Aminodichlorphosphan

C<sub>6</sub>H<sub>15</sub>ClNPSi

C6H15ClNPSi

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

Conditions
Conditions Yield
at 319.84 ℃; Thermolysis;

Global suppliers and manufacturers

Global( 239) Suppliers
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  • Simagchem Corporation
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  • Chemwill Asia Co., Ltd.
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  • Main Products:30
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  • Amadis Chemical Co., Ltd.
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  • Shaanxi BLOOM TECH Co.,Ltd
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