3397-62-4Relevant articles and documents
Synthesis of DNA-Binding Peptoids
Mao, Jie,Bong, Dennis
, p. 1581 - 1585 (2015)
Programmable molecular recognition through nucleic acid base pairing has enabled applications in nano- and biotechnology using DNA, RNA, PNA, and more recently, bifacial PNA (bPNA). We describe herein the synthesis and DNA recognition properties of peptoid backbones bearing the bifacial synthetic nucleobase melamine. These 'peptoid nucleic acids' hybridize with thymine-rich DNA, like their peptide cognate (bPNA). DNA complexation is highly sensitive to peptoid side-chain length and overall charge. Peptoids isomeric with peptide bPNA were less efficient at DNA recognition, possibly due to conformational and steric differences. 1 Triazines and DNA Molecular Recognition 2 Synthesis of DNA-Binding Peptoids 3 Peptoid-DNA Binding Studies
Safe and environment-friendly cyromazine synthesis method
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Paragraph 0006; 0019-0028, (2021/03/18)
The invention discloses a safe and environment-friendly cyromazine synthesis method which comprises the following steps: reacting cyanuric chloride serving as a raw material with ammonium salt under the action of a catalyst to obtain an intermediate 2-chlorine-4, 6-diamino-1, 3, 5-triazine, and reacting the intermediate 2-chlorine-4, 6-diamino-1, 3, 5-triazine with cyclopropylamine to obtain cyromazine. According to the method, the ammonium salt is used as the source of ammonia, the yield of cyromazine can be effectively increased under the action of the catalyst, high-pollution flammable andexplosive ammonia water or liquid ammonia can be prevented from being used, meanwhile, due to the fact that the use amount of the ammonium salt is greatly reduced, the ammonia nitrogen value in the wastewater can be reduced, pollution is reduced from the source, and the process safety is improved; the treatment difficulty and the treatment cost of the wastewater can also be reduced.
Preparation method of cyromazine
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Paragraph 0023; 0025; 0027; 0029; 0031; 0033; 0035; 0037; 00, (2020/09/16)
The invention discloses a preparation method of cyromazine. Melamine is used as an initial raw material; the preparation method comprises the following steps: carrying out an acidic hydrolysis reaction to obtain 4, 6-diamino-2-hydroxy-1, 3, 5-triazine, carrying out a chlorination reaction on 4, 6-diamino-2-hydroxy-1, 3, 5-triazine to obtain a toluene solution of 4, 6-diamino-2-chloro-1, 3, 5-triazine, and carrying out an amination reaction on 4, 6-diamino-2-chloro-1, 3, 5-triazine and cyclopropylamine so as to generate cyromazine. According to the method, toxic 2-cyclopropylamino-4, 6-dichloro-S-triazine is prevented from being generated, ammoniation pressurizing equipment is prevented from being used, reaction conditions are milder, cheaper materials are used, and the prepared cyclopropylamine is high in yield and good in quality.
SUBSTITUTED (PIPERIDIN-1-YL)ARYL ANALOGUES FOR MODULATING AVILACTIVITY
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Paragraph 0364; 0367, (2020/11/12)
In one aspect, the disclosure relates to compounds useful to regulate, limit, or inhibit the expression of AVIL (advillin), methods of making same, pharmaceutical compositions comprising same, and methods of treating disorders associated with AVIL dysregulation using same. In aspects, the disclosed compounds, compositions and methods are useful for treating disorders or diseases in which the regulation, limitation, or inhibition of the expression of AVIL can be clinically useful, such as, for example, the treatment of cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Integrated photocatalytic-biological treatment of triazine-containing pollutants
Chan, Cho Yin,Chan, Ho Shing,Wong, Po Keung
, p. 371 - 380 (2019/02/07)
The degradation of triazine-containing pollutants including simazine, Irgarol 1051 and Reactive Brilliant Red K-2G (K-2G) by photocatalytic treatment was investigated. The effects of titanium dioxide (TiO2) concentration, initial pH of reaction mixture, irradiation time and ultraviolet (UV) intensity on photocatalytic treatment efficiency were examined. Complete decolorization of K-2G was observed at 60 min photodegradation while only 15 min were required to completely degrade simazine and Irgarol 1051 under respective optimized conditions. High-performance liquid chromatography (HPLC), gas chromatography/mass spectrometry (GC/MS) and ion chromatography (IC) were employed to identify the photocatalytic degradation intermediates and products. Dealkylated intermediates of simazine, deisopropylatrazine and deethyldeisopropylatrazine, and Irgarol 1051 were detected by GC/MS in the initial phase of degradation. Complete mineralization could not be achieved for all triazine-containing pollutants even after prolonged (>72 h) UV irradiation due to the presence of a photocatalysis-resistant end product, cyanuric acid (CA). The toxicities of different compounds before and after photocatalytic treatment were also monitored by three bioassays. To further treat the photocatalysis-resistant end product, a CA-degrading bacterium was isolated from polluted marine sediment and further identified as Klebsiella pneumoniae by comparing the substrate utilization pattern (Biolog microplate), fatty acid composition and 16S rRNA gene sequencing. K. pneumoniae efficiently utilized CA from 1 to 2000 mg/L as a good nitrogen source and complete mineralization of CA was observed within 24 h of incubation. This study demonstrates that the biodegradability of triazine-containing pollutants was significantly improved by the photocatalytic pre-treatment, and this proposed photocatalytic-biological integrated system can effectively treat various classes of triazine-containing pollutants.
Synthesis, characterization and determination of HOMO-LUMO of the substituted 1,3,5-triazine molecule for the applications of organic electronics
Pakkath, Rajeesh,Eeda, Koti Reddy,Kuriakose, Sheena,Saritha,Sajith, Ayyiliath M.,Karuvalam, Ranjith Pakkath,Haridas, Karickal Raman
, p. 352 - 359 (2019/10/16)
The most important parameter of organic molecules for energy harvesting application focuses mainly on their band gap (HOMO-LUMO). In this report, we synthesized differently substituted 1,3,5-triazine based organic molecule which on future processing can be used in organic electronics like solar cells and OLED's. The energy gap of the synthesized novel analogue was calculated using cyclic voltammetry, UV-Visible spectroscopy and compared with density functional theory (DFT) studies.
A cyclopropanecarboxylic ammonia qin preparation method (by machine translation)
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Paragraph 0032; 0036; 0038; 0040, (2018/08/04)
A cyclopropanecarboxylic ammonia qin preparation method, comprises the following steps: 1) under stirring conditions, for 0 - 5 °C lower, the cyanuric chloride is dissolved in organic solvent, drip and processing industry ammonia water, heated to 40 - 45 °C, thermal insulation reaction 5 - 6.5 h, to the reaction solution, the separated solvent, is added to the residual liquid purified water, stirring 1 - 1.5 h, to room temperature, filtered, washing, drying, get intermediate, the intermediate body is 2 - chloro - 4.6 - diamino - 1.3.5 - triazine; 2) at room temperature, step 1) preparation of the intermediate is added to the purification in the water, and then adding the amine, heating up to 90 - 95 °C, [...], adjusting the pH to 7.5 - 8.5; then the 98 - 100 °C lower, reaction 3.5 - 4.5 h, decoloring, filter, to obtain a reaction solution; cooling to 40 - 50 °C, crystalline 1 - 2 h, to cool down to - 5 - 0 °C, filtered, washed, dried, a cyclopropanecarboxylic ammonia qin. Preparation method of the invention, the process is simple, high safety, low cost, convenient to industrial production, and the product has high purity, low impurity content, good stability. (by machine translation)
Understanding the effect of an amino group on the selective and ultrafast detection of TNP in water using fluorescent organic probes
Das, Prasenjit,Mandal, Sanjay K.
, p. 3288 - 3297 (2018/04/05)
We have designed and developed three single-molecule fluorescent probes differing in the number of amino groups, namely 5-((4,6-Diamino-1,3,5-triazin-2-yl)amino)isophthalic acid (H2ATAIA, 1), 5-((4-amino-6-methoxy-1,3,5-triazin-2-yl)amino)isophthalic acid (H2AMTAIA, 2) and 5-((4,6-dimethoxy-1,3,5-triazin-2-yl)amino)isophthalic acid (H2DMTAIA, 3), from cheap and readily available starting materials via simple procedures in high yields for demonstrating their application in highly selective and ultrafast sensing of 2,4,6-trinitrophenol (TNP) in water (slurry mode). Probes 1-3 have been characterized by various analytical techniques, such as melting point, FTIR, UV-vis and NMR (1H and 13C) spectroscopy and high resolution mass spectrometry (HRMS). It is quite evident that the effect of an amino group is more prominent compared to a methoxy group towards the selective detection of TNP over other potentially interfering nitro compounds. The detection limit for the diamino derivative was found to be 120 ppb compared to those with one amino or no amino group (0.8 ppm and 1.2 ppm, respectively). We also report the ideal real time detection of TNP through a contact mode or instant spot via paper strips. Spectral overlap, time-resolved fluorescence studies, quantum yield, Stern-Volmer plots, field emission scanning electron microscopy (FESEM) and DFT calculations have been used to establish their mechanism of action. Furthermore, competitive nitro-analyte tests demonstrate that the selectivity for TNP is more in 1 compared to 2 and 3. To the best of our knowledge, we have demonstrated for the first time molecular decoding of TNP based on the dual read-out identification scheme constructed from life-time and quantum yield. These probes have been found to be highly photostable in the presence of acidic TNP as well as recyclable without much loss of sensitivity up to five cycles. These results vividly depict that these are excellent candidates for environmental monitoring.
N-Methylmelamines: Synthesis, Characterization, and Physical Properties
List, Manuela,Puchinger, Helmut,Gabriel, Herbert,Monkowius, Uwe,Schwarzinger, Clemens
, p. 4066 - 4075 (2016/06/09)
N-Methylmelamines have recently gained importance as valuable compounds for manufacturing modified melamine formaldehyde resins and other polymer building blocks. A great advantage of these polymers is the reduction of the carcinogenic formaldehyde. Selecting the polymerization processes (e.g., substance polymerization, polymerization in solution) and controlling the polymerization reaction and properties of these novel materials requires knowledge of the properties of the individual melamine derivatives used as new building blocks. All possible permutations of N-methylmelamines were prepared, and reaction progress was monitored by GC/MS. 2,4,6-Tris(dimethylamino)-1,3,5-triazine was prepared to complete the series; this is, however, also a possible byproduct in various synthesis routes. The reaction conditions were optimized to obtain high yields of each derivative with the highest possible purity. The substances were characterized by NMR and IR spectroscopy, mass spectrometry, elemental analysis, and single-crystal X-ray diffraction. In addition, physical properties, such as solubility, melting points, and pKb values, were determined. The number of amino-, methylamino-, and dimethylamino groups has a significant effect on these properties. In summary, we found that by increasing the number of amino- and methylamino groups, solubility and pKb increase. With increasing number of amino groups, the compounds tend to form hydrogen bonds, and thus, the melting point shifts to higher temperature ranges where they start to decompose.
Halogen-free expansion type flame retardant containing thiotriazinone phosphoramidate and preparation method thereof
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Paragraph 0032; 0033; 0034; 0035, (2016/10/31)
The invention relates to a halogen-free expansion type flame retardant containing thiotriazinone phosphoramidate and a preparation method thereof. Tricyanogen chloride, piperazine, organic amine, ammonia water and phosphoryl chloride serve as main raw materials, the compound is prepared through replacing and condensation reactions, and the advantages that the raw materials are easy to obtain and production is stable are achieved. The obtained compound containing P-N piperazine-riazine-phosphate ester structural units combines a carbon source, a gas source and an acid source into one molecular structure. The flame retardant has good water-resistant characteristic and can serve as flame retardant of most high-polymer materials, and good application prospects are achieved.
