345-92-6

Basic information

• Product Name: Bis(4-fluorophenyl)-methanone
• Synonyms: 4,4’-difluoro-benzophenon;Benzophenone, 4,4'-difluoro-;bis(4-fluorophenyl)-methanon;Bis(p-fluorophenyl) ketone;bis(p-fluorophenyl)ketone;Di-p-fluorophenyl ketone;di-p-fluorophenylketone;Methanone, bis(4-fluorophenyl)-
• CAS NO: 345-92-6
• Molecular Formula: C₁₃H₈F₂O
• Molecular Weight: 218.2
• EINECS: 206-466-3
• Product Categories: Fluorobenzene Series;FINE Chemical & INTERMEDIATES;Aromatic Benzophenones & Derivatives (substituted);Benzophenones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research;C13 to C14;Carbonyl Compounds;Ketones;Pharmaceutical raw materials
• Mol File: 345-92-6.mol
• Article Data: 135

Chemical Properties

• Melting Point: 102-105 °C(lit.)
• Boiling Point: 137°C (3 torr)
• Flash Point: 170-172°C/10mm
• Appearance: White to slightly yellow/Crystalline Powder
• Density: 1.2543 (estimate)
• Vapor Pressure: 0.005Pa at 20℃
• Storage Temp.: Store below +30°C.
• Solubility: Insoluble in water
• Water Solubility: 8.757mg/L at 20℃
• BRN: 516231
• CAS DataBase Reference: Bis(4-fluorophenyl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: Bis(4-fluorophenyl)-methanone(345-92-6)
• EPA Substance Registry System: Bis(4-fluorophenyl)-methanone(345-92-6)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 36/37/38-51/53-22
• Safety Statements: 26-37/39-36-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: DJ0685000
• HazardClass: IRRITANT
• Hazardous Substances Data: 345-92-6(Hazardous Substances Data)

Usage

Chemical Properties

white to slightly yellow crystalline powder

Uses

4,4′-Difluorobenzophenone has been used in the study of thermal stability, water uptake and proton conductivity of carboxylated, carboxylated/sulfonated, and crosslinked membranes.

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 540, 1968 DOI: 10.1021/ja01004a087

General Description

4,4′-Difluorobenzophenone is typically used as a starting material for the preparation of polyetheretherketone (PEEK) polymer, a high-temperature thermoplastic, which finds wide use in dentistry as well as in automotive, oil industries, etc.

Synthetic route

4,4'-difluorodiphenylmethane (457-68-1) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With pyridine; tert.-butylhydroperoxide In decane; acetonitrile at 80℃; for 24h;	99%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; C12H8Cl3FeN2O4Zr4; oxygen; sodium nitrite In acetonitrile at 60℃; under 760.051 Torr; for 24h;	99%
With oxygen; sodium t-butanolate In dimethyl sulfoxide at 50℃; for 5h; Sealed tube;	97%

4,4'-(azidomethylene)bis(fluorobenzene) (1093981-40-8) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With tert.-butylhydroperoxide; vanadia In water at 100℃; for 6h;	99%

chloroformic acid ethyl ester (541-41-3) + 4-fluorophenylzinc bromide (181705-93-1) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
at 20℃; for 3h;	99%

4,4'-difluorobenzhydryl alcohol (365-24-2) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With potassium carbonate; chlorobenzene; CyJohnPhos; bis(dibenzylideneacetone)-palladium(0) In toluene at 105℃; for 12h;	98%
With potassium carbonate; chlorobenzene In toluene at 105℃; for 12h;	98%
With potassium tetrakis-μ-pyrophosphitodiplatinate(II); tetrabutyl-ammonium chloride In dichloromethane; water at 20℃; for 8h; Inert atmosphere; Irradiation;	98%

4-fluoroboronic acid (1765-93-1) + 4-fluorobenzoyl chloride (403-43-0) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With C28H40Br4N4Pd2; potassium carbonate In ethanol; water at 50℃; for 2h; Suzuki Coupling;	96%
With [Pd(3-[(2,6-diisopropylphenyl)-1-imidazolio]-2-quinoxalinide)(PPh3)Cl2]; potassium carbonate In water at 100℃; for 3h; Suzuki-Miyaura Coupling;	88%

4,4’-difluorobenzophenone oxime (363-02-0) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With sodium nitrite In water; acetonitrile at 40℃; for 2.66667h;	95%
With ferrous(II) sulfate heptahydrate; benzyl seleninic acid In ethyl acetate at 60℃; for 24h; Green chemistry;	93%
With dibenzyl diselenide; dihydrogen peroxide In acetonitrile at 60℃; for 24h;	72%

4-fluorobenzenediazonium tetrafluoroborate (459-45-0) + 4-fluorobenzaldehyde (459-57-4) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With di-tert-butyl peroxide In 1,2-dichloro-ethane at 80℃; for 1h;	93%

4-fluoro-1-iodobenzene (352-34-1) + molybdenum hexacarbonyl (13939-06-5, 199620-15-0) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With 4,4'-di-tert-butyl-2,2'-bipyridine; nickel dibromide; zinc In 1,4-dioxane at 120℃; for 6h; Inert atmosphere; Sealed tube;	93%

1-(bis(4-fluorophenyl)methyl)-3-(4-bromophenyl)urea → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With 2,4,6-triphenylpyrylium tetrafluoroborate at 35℃; for 7h; Irradiation;	92%

dichloro-bis-(4-fluoro-phenyl)-methane (312-33-4) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With water for 5h;	91%
With ethanol

4-fluoro-1-iodobenzene (352-34-1) + carbon monoxide (201230-82-2) + 4-fluoroboronic acid (1765-93-1) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With potassium phosphate; palladium diacetate at 20℃; for 3h;	90%
With iron(III) chloride; potassium acetate; sodium hydrogencarbonate; iron(II) chloride at 100℃; under 760.051 Torr; for 6h; Suzuki Coupling; Schlenk technique;	85%
With palladium diacetate; sodium carbonate In water at 100℃; under 760.051 Torr; for 8h; Suzuki Coupling; Sealed tube; Autoclave; Green chemistry;	84%
With potassium phosphate; nickel dichloride; Trimethylacetic acid at 80℃; under 760.051 Torr; for 24h;	75%

carbon monoxide (201230-82-2) + potassim 4-fluorophenyltrifluoroborate → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With iodine; palladium diacetate; sodium carbonate at 80℃; under 760.051 Torr; for 12h;	88%

oxalyl dichloride (79-37-8) + tris(4-fluorophenyl)bismuthane (437-29-6) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 80℃; for 4h; Inert atmosphere;	86%

benzoyl chloride (98-88-4) + tributyl(naphthalene-2-yl)stannane (972-11-2) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With palladium diacetate In chloroform at 60℃; for 2h; Stille Cross Coupling; Inert atmosphere;	85%

tert-butylisonitrile (119072-55-8, 7188-38-7) + 4-fluoroboronic acid (1765-93-1) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With water; copper hydroxide; ammonium chloride; palladium dichloride In toluene at 100℃; for 16h; Schlenk technique;	85%

1,1-bis-(4-fluorophenyl)ethene (6175-14-0) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With sodium tetrafluoroborate; [Cu(salicylate)2(NCMe)]2; tetrabutyl-ammonium chloride; oxygen In tetrahydrofuran at 60℃; for 12h;	85%
With di-tert-butyl peroxide; iron(II) chloride In decane; acetonitrile at 20℃; for 8h; Inert atmosphere; Schlenk technique;	82%

1-(4-fluorobenzoyl)pyrrolidine-2,5-dione (331987-63-4) + potassim 4-fluorophenyltrifluoroborate → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With palladium diacetate; potassium carbonate In water at 20℃; for 6h; Suzuki-Miyaura Coupling; Green chemistry;	84%

bis(4-fluorophenyl)methanone O-(4-(tert-butyl)benzoyl) oxime → 1-tert-butyl-4-iodobenzene (35779-04-5) + 4,4'-difluorobenzophenone imine (80529-17-5) + 1,2-bis(bis(4-fluorophenyl)methylene)hydrazine + 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With Chloroiodomethane; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate In ethyl acetate for 12h; Quantum yield; Reagent/catalyst; Schlenk technique; Inert atmosphere; Irradiation;	A 83% B 51 %Chromat. C 11% D 17 %Chromat.

fluorobenzene (462-06-6) + carbon monoxide (201230-82-2) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); iodine; silver trifluoromethanesulfonate at 150℃; under 3040.2 Torr; for 22h;	82%

dimethylsulfone (67-71-0) + 4,4'-Dichlorobenzophenone (90-98-2) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With potassium fluoride In water; isopropyl alcohol; benzene	80%

carbon monoxide (201230-82-2) + 4-fluoroboronic acid (1765-93-1) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With oxygen; palladium diacetate; potassium hydrogencarbonate; sodium iodide at 80℃; under 760.051 Torr; for 23h;	80%
With tetrakis(triphenylphosphine) palladium(0); 1,3-bis-(diphenylphosphino)propane; silver nitrate In acetone at 40℃; under 760.051 Torr; for 24h; Autoclave; Inert atmosphere;	72%
With bis-triphenylphosphine-palladium(II) chloride; oxygen; copper(l) chloride In N,N-dimethyl-formamide at 80℃; for 24h; Schlenk technique;	65%

tris(4-fluorophenyl)indium + oxalyl dichloride (79-37-8) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 60℃; for 4h;	79%

dimethylsulfone (67-71-0) + bis(4-bromophenyl)methanone (3988-03-2) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With potassium fluoride	78%

4-fluoro-1-iodobenzene (352-34-1) + 4-fluorobenzaldehyde (459-57-4) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
Stage #1: 4-fluoro-1-iodobenzene With TurboGrignard In tetrahydrofuran at -40 - -10℃; for 0.25h; Inert atmosphere; Stage #2: With zinc(II) chloride In tetrahydrofuran for 0.5h; Inert atmosphere; Stage #3: 4-fluorobenzaldehyde With pivalaldehyde In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Cooling with ice;	78%

carbon monoxide (201230-82-2) + 4-fluoroboronic acid (1765-93-1) + 1-Bromo-4-fluorobenzene (460-00-4) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 120℃; under 760.051 Torr; for 4h; Suzuki Coupling; Sealed tube;	77%

1-Bromo-4-fluorobenzene (460-00-4) + N,N-Dimethylcarbamoyl chloride (79-44-7) → 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
Stage #1: 1-Bromo-4-fluorobenzene With n-butyllithium In diethyl ether; hexane at -50 - -30℃; for 3h; Metallation; Stage #2: N,N-Dimethylcarbamoyl chloride In diethyl ether; hexane at -50 - 0℃; for 3h; Acylation;	75%

3,3-Dichloro-4,4'-difluorobenzophenone → 4,4,-difluorobenzophenone + 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With sodium formate; palladium In ethanol	A n/a B 73%

1,1-bis-(4-fluorophenyl)ethene (6175-14-0) + 1-(phenylsulfinyl)propan-2-one (33840-74-3) → 2,2-bis(4-fluorophenyl)-2-hydroxyethyl acetate (135507-99-2) + 4,4'-Difluorobenzophenone (345-92-6) + 6,6-bis(4-fluorophenyl)-3-methyl-4-(phenylsulfinyl)-1,2-dioxan-3-ol

Conditions	Yield
With oxygen; manganese triacetate In acetic acid at 32℃; for 12h;	A 1% B 11% C 72%

1,1-bis-(4-fluorophenyl)ethene (6175-14-0) + manganese(III) acetylacetonate (14284-89-0) → 5,5-Bis(4-fluorphenyl)-4,5-dihydro-2(3H)-furanon (63295-11-4) + 4-acetyl-6,6-bis(4-fluorophenyl)-3-methyl-1,2-dioxan-3-ol (133216-68-9) + 2,2-bis(4-fluorophenyl)-2-hydroxyethyl acetate (135507-99-2) + 4,4'-Difluorobenzophenone (345-92-6)

Conditions	Yield
With air; acetic acid at 23℃; for 12h; Further byproducts given;	A 2% B 72% C 4% D 2%

4,4'-Difluorobenzophenone (345-92-6) + 1-phenylprop-2-en-1-amine hydrochloride → [bis-(4-fluoro-phenyl)-methylene]-(1-phenyl-allyl)-amine

Conditions	Yield
With titanium tetrachloride; triethylamine In 1,2-dimethoxyethane at -78 - 20℃;	100%

(methoxymethyl)triphenylphosphonium chloride (4009-98-7) + 4,4'-Difluorobenzophenone (345-92-6) → 1,1-bis(4-fluorophenyl)-2-methoxyethene (53780-24-8)

Conditions	Yield
With sodium hexamethyldisilazane In tetrahydrofuran; 1,4-dioxane for 2h; Wittig olefination; Heating;	100%
Stage #1: (methoxymethyl)triphenylphosphonium chloride With n-butyllithium In 1,4-dioxane; hexane at 0℃; Wittig reaction; Stage #2: 4,4'-Difluorobenzophenone In 1,4-dioxane; hexane at 0℃; Wittig reaction; Reflux;	82%

4,4'-Difluorobenzophenone (345-92-6) → 4,4'-difluorobenzophenone imine (80529-17-5)

Conditions	Yield
With ammonia; titanium tetrachloride In toluene at -30℃;	100%
With 1,1,1,3,3,3-hexamethyl-disilazane; scandium tris(trifluoromethanesulfonate) In chlorobenzene at 90℃; for 2h; Inert atmosphere;	99%
With ammonia; titanium tetrachloride In toluene Inert atmosphere;	82%
titanium tetrachloride In toluene

3-Bromophenol (591-20-8) + potassium carbonate (584-08-7) + 4,4'-Difluorobenzophenone (345-92-6) → 4,4'-bis(3-bromophenoxy)benzophenone

Conditions	Yield
In ISOPROPYLAMIDE; toluene	100%

4,4'-Difluorobenzophenone (345-92-6) → 4,4’-difluorobenzophenone oxime (363-02-0)

Conditions	Yield
With hydroxylamine hydrochloride In ethanol Heating;	99%
With hydroxylamine; sodium hydroxide In methanol at 40℃; for 0.166667h;	91.9%
With hydroxylamine hydrochloride; sodium hydroxide In ethanol; water Reflux;	88.5%

4,4'-Difluorobenzophenone (345-92-6) → 1,1,2,2-tetrakis-(4-fluorophenyl)-ethane-1,2-diol (424-82-8)

Conditions	Yield
With CdS(x)Se(1-x) x:0-1;; para-thiocresol In hexane for 22h; Inert atmosphere; Irradiation;	99%
With indium(III) chloride; ammonium chloride; aluminium In ethanol; water at 80℃; for 5h;	98%
With methanol; gallium nitride at 20℃; for 12h; Irradiation; Sealed tube;	96%

indole (120-72-9) + 4,4'-Difluorobenzophenone (345-92-6) → bis(4-(1H-indol-1-yl)phenyl)methanone

Conditions	Yield
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 160℃; for 4h; Reagent/catalyst; Solvent; Temperature; Schlenk technique; Inert atmosphere;	99%
With caesium carbonate In dimethyl sulfoxide at 70℃; for 15h; Inert atmosphere;	75%

1.3-propanedithiol (109-80-8) + 4,4'-Difluorobenzophenone (345-92-6) → 2,2-bis(4-fluorophenyl)-1,3-dithiane

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; Inert atmosphere;	99%
With boron trifluoride diethyl etherate; sodium sulfate In chloroform at 0 - 20℃; Inert atmosphere;

4,4'-Difluorobenzophenone (345-92-6) + methyl (triphenylphosphoranylidene)acetate (21204-67-1) → methyl 3,3-bis(4-fluorophenyl)prop-2-enoate

Conditions	Yield
In toluene for 36h; Wittig Olefination; Reflux;	99%

BPA (80-05-7) + 4,4'-Difluorobenzophenone (345-92-6) → polymer; monomer(s): 4,4\-difluorobenzophenone; 2,2-bis(4\-hydroxyphenyl)propane

Conditions	Yield
With N,N-dimethyl acetamide; potassium carbonate In chlorobenzene at 185℃; for 10h;	98.5%

4,4'-Difluorobenzophenone (345-92-6) → 4,4'-difluorobenzhydryl alcohol (365-24-2)

Conditions	Yield
With sodium tetrahydroborate In methanol at 0℃; for 1h; Inert atmosphere;	98%
With methanol; sodium tetrahydroborate at 0 - 20℃;	96%
With sodium tetrahydroborate In methanol at 20℃;	96%

BPA (80-05-7) + 4,4'-Difluorobenzophenone (345-92-6) → polymer, inherent viscosity 0.20 dL/g at 25 deg C; monomer(s): bisphenol A; 4,4\-difluorobenzophenone

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide; toluene at 140 - 145℃; for 6h;	98%

BPA (80-05-7) + 4,4'-Difluorobenzophenone (345-92-6) → polymer, inherent viscosity 0.23 dL/g at 25 deg C; monomer(s): bisphenol A; 4,4\-difluorobenzophenone

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one; toluene at 150 - 155℃; for 6h;	98%

4-tert-Butylcatechol (98-29-3) + 4,4'-Difluorobenzophenone (345-92-6) → polymer, inherent viscosity 0.14 dL/g at 25 deg C; monomer(s): 4-tert-butylcatechol; 4,4\-difluorobenzophenone

Conditions	Yield
With potassium carbonate In sulfolane; xylene at 170 - 175℃; for 6h;	98%

4,4'-Difluorobenzophenone (345-92-6) + trimethylsilylacetylene (1066-54-2) → 1,1-bis(4-fluorophenyl)prop-2-yn-1-ol (357-77-7)

Conditions	Yield
Stage #1: trimethylsilylacetylene With n-butyllithium In tetrahydrofuran at -10℃; for 1h; Stage #2: 4,4'-Difluorobenzophenone In tetrahydrofuran at -10℃; for 5h; Stage #3: With methanol; potassium hydroxide In tetrahydrofuran at 0 - 20℃; for 12h;	98%
Stage #1: trimethylsilylacetylene With n-butyllithium In tetrahydrofuran; hexane at -10℃; for 1h; Inert atmosphere; Stage #2: 4,4'-Difluorobenzophenone In tetrahydrofuran; hexane at -10℃; for 3h; Stage #3: With water; sodium hydroxide In methanol at 0 - 20℃;	96%
Stage #1: 4,4'-Difluorobenzophenone; trimethylsilylacetylene With n-butyllithium In tetrahydrofuran Stage #2: With potassium hydroxide In methanol

disodium 5,5'-carbonyl bis(2-fluorobenzenesulfonate) + C40H26N4O4 (599205-72-8) + 4,4'-Difluorobenzophenone (345-92-6) → polymer, number of sulfonic acid groups per repeating unit 1.67; monomer(s): 4,4'-[biphenyl-4,4'-diylbis(oxybenzene-4,1-diyl)]diphthalazin-1(2H)-one; sodium 4,4'-difluorobenzophenone-3,3'-disulfonate; 4,4'-difluorobenzophenone

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 140 - 175℃; for 22h;	98%

disodium 5,5'-carbonyl bis(2-fluorobenzenesulfonate) + C40H26N4O4 (599205-72-8) + 4,4'-Difluorobenzophenone (345-92-6) → polymer, number of sulfonic acid groups per repeating unit 1.24; monomer(s): 4,4'-[biphenyl-4,4'-diylbis(oxybenzene-4,1-diyl)]diphthalazin-1(2H)-one; sodium 4,4'-difluorobenzophenone-3,3'-disulfonate; 4,4'-difluorobenzophenone

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 140 - 175℃; for 22h;	98%

4,4'-Difluorobenzophenone (345-92-6) + phenylhydrazine (100-63-0) → 1-(bis(4-fluorophenyl)methyl)-1-phenylhydrazine

Conditions	Yield
Stage #1: 4,4'-Difluorobenzophenone; phenylhydrazine With N,N,N,N,N,N-hexamethylphosphoric triamide In dichloromethane at 25℃; for 0.166667h; Inert atmosphere; Stage #2: With trichlorosilane In dichloromethane at 25℃; for 12h; Inert atmosphere;	98%

N,N-diethyl-2,2-difluoroacetamide (686-11-3) + 4,4'-Difluorobenzophenone (345-92-6) → N,N-diethyl-3,3-bis(4-fluorophenyl)-3-hydroxy-2,2-difluoropropanamide

Conditions	Yield
With potassium hexamethylsilazane In toluene at 20℃; for 0.25h; Inert atmosphere;	98%

tert-butyl 3-benzyl-2-((tert-butyldimethylsilyl)oxy)-1H-indole-1-carboxylate + 4,4'-Difluorobenzophenone (345-92-6) → tert-butyl 2a-benzyl-7a-((tert-butyldimethylsilyl)oxy)-2,2-bis(4-fluorophenyl)-2a,7a-dihydrooxeto[2,3-b]indole-7(2H)-carboxylate

Conditions	Yield
In toluene at 20℃; for 0.2h; Paterno-Buechi Cycloaddition; Inert atmosphere; Irradiation; diastereoselective reaction;	98%

BPA (80-05-7) + 4,4'-Difluorobenzophenone (345-92-6) → polymer, Mn ca. 4500 Da, Mw ca. 20000 Da, inherent viscosity 0.21 dL/g at 25 deg C; monomer(s): bisphenol A; 4,4\-difluorobenzophenone

Conditions	Yield
With potassium carbonate In sulfolane; toluene at 150 - 155℃; for 6h;	97%

4-tert-Butylcatechol (98-29-3) + 4,4'-Difluorobenzophenone (345-92-6) → polymer, Mn 3000 Da, Mw 13000 Da, inherent viscosity 0.08 dL/g at 25 deg C; monomer(s): 4-tert-butylcatechol; 4,4\-difluorobenzophenone

Conditions	Yield
With potassium carbonate In sulfolane; toluene at 150 - 155℃; for 6h;	97%

4-tert-Butylcatechol (98-29-3) + 4,4'-Difluorobenzophenone (345-92-6) → polymer, Mn 3000 Da, Mw 17000 Da, inherent viscosity 0.10 dL/g at 25 deg C; monomer(s): 4-tert-butylcatechol; 4,4\-difluorobenzophenone

Conditions	Yield
With potassium carbonate In sulfolane; xylene at 170 - 175℃; for 6h;	97%

disodium 5,5'-carbonyl bis(2-fluorobenzenesulfonate) + C40H26N4O4 (599205-72-8) + 4,4'-Difluorobenzophenone (345-92-6) → polymer, number of sulfonic acid groups per repeating unit 1.02; monomer(s): 4,4'-[biphenyl-4,4'-diylbis(oxybenzene-4,1-diyl)]diphthalazin-1(2H)-one; sodium 4,4'-difluorobenzophenone-3,3'-disulfonate; 4,4'-difluorobenzophenone

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 140 - 175℃; for 22h;	97%

BPA (80-05-7) + 4,4'-Difluorobenzophenone (345-92-6) → C43H38O5 (129284-07-7)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; toluene at 135 - 145℃; for 12h; Inert atmosphere;	97%

Upstream product

• 90-98-2 4,4'-Dichlorobenzophenone 
• 2146-77-2 HgBr(p-FC₆H₄) 
• 1817-74-9 bis(4-nitrophenyl)methane 
• 6175-14-0 1,1-bis-(4-fluorophenyl)ethene 
• 64-19-7 acetic acid 
• 403-43-0 4-fluorobenzoyl chloride 
• 53117-13-8 4,4'-difluorothiobenzophenone 
• 365-24-2 4,4'-difluorobenzhydryl alcohol 
• 14284-89-0 manganese(III) acetylacetonate 
• 33840-74-3 1-(phenylsulfinyl)propan-2-one 
• 462-06-6 fluorobenzene 
• 569-74-4 1,1-dichloro-2,2-bis-(4-fluoro-phenyl)-ethene 
• 312-33-4 dichloro-bis-(4-fluoro-phenyl)-methane 
• 75-44-5 phosgene 

Downstream Products

• 16574-54-2 (4-(dimethylamino)phenyl)(4-fluorophenyl)methanone 
• 90-94-8 bis(p-dimethylaminophenyl)methanone 
• 10345-72-9 4,4'-difluorobenzophenone dimethyl acetal 
• 435-08-5 1,1,2,2-tetrakis(4-fluoroophenyl)ethylene 
• 733-83-5 2,2,2-trifluoro-1,1-bis(4-fluorophenyl)ethanol 
• 99734-06-2 α,α-bis(4-fluorophenyl)allyl alcohol 
• 301523-77-3 (4-fluoro-phenyl)-(4-piperazin-1-yl-phenyl)-methanone 
• 302798-05-6 (Z)-Bis(4-fluorophenyl)methylene[1-(2,5-dimethyl-3-furyl) ethylidene]succinic anhydride 
• 131225-71-3 1,1-bis(4'-fluorophenyl)-1-pentene 
• 241823-93-8 2,3,4,4',4'',5,6-heptafluoro-triphenylmethanol 
• 426-72-2 tetrakis-(4-fluoro-phenyl)-ethanone 
• 210627-73-9 2-{[2,2-Bis-(4-fluoro-phenyl)-2-hydroxy-ethyl]-phenyl-phosphinoyl}-1,1-bis-(4-fluoro-phenyl)-ethanol 

Relevant articles and documents

Preparation method 4,4 ' -difluorobenzophenone and intermediate thereof

The invention discloses 4-4' -difluorobenzophenone and a preparation method of an intermediate thereof. The preparation method of 4, 4 '- difluorobenzophenone comprises the following steps: S1: 4 - chlorobenzyl chloride and chlorobenzene react under first catalyst to obtain 4, 4' -dichlorophenylmethane. The first catalyst is Lewis acid and/or a molecular sieve with Lewis acid center. S2: The 4, 4 '-dichlorophenylmethane and oxidant are subjected to an oxidation reaction under the action second catalyst to obtain 4, 4' -dichlorobenzophenone. S3: The 4, 4' -dichlorobenzophenone and the alkali metal fluoride are subjected to a halogenation reaction to obtain the invention. The 4' - difluorobenzophenone and the intermediate thereof disclosed by the invention are high in selectivity, high in yield, low in raw material cost, mild in process condition, high in safety and wide in industrial prospect.

Ruthenium-on-Carbon-Catalyzed Facile Solvent-Free Oxidation of Alcohols: Efficient Progress under Solid-Solid (Liquid)-Gas Conditions

A protocol for the ruthenium-on-carbon (Ru/C)-catalyzed solvent-free oxidation of alcohols, which proceeds efficiently under solid-solid (liquid)-gas conditions, was developed. Various primary and secondary alcohols were transformed to corresponding aldehydes and ketones in moderate to excellent isolated yields by simply stirring in the presence of 10% Ru/C under air or oxygen conditions. The solvent-free oxidation reactions proceeded efficiently regardless of the solid or liquid state of the substrates and reagents and could be applied to gram-scale synthesis without loss of the reaction efficiency. Furthermore, the catalytic activity of Ru/C was maintained after five reuse cycles.

Preparation method of benzophenone derivative

The invention provides a preparation method of a benzophenone derivative. The preparation method comprises the following step: subjecting a benzoic acid compound as shown in a formula I, a trichlorotoluene compound as shown in a formula II and a benzene compound as shown in a formula III to reacting under the catalysis of Fe2O3 to obtain the benzophenone derivative. According to the preparation method provided by the invention, the metal oxide Fe2O3 with higher stability and safety is used as a catalyst, so corrosion of materials to equipment is avoided, and the preparation method is more environment-friendly; according to the preparation method, the target product is obtained through one-step reaction, reaction conditions are mild, and a process is simple; and the main byproduct benzoic acid compound generated by the reaction can be recycled by washing, extracting and desolventizing in post-treatment, and then is used as a reaction raw material for preparing the benzophenone derivative again, so wastewater treatment cost is reduced, and resources are fully utilized.