118-69-4Relevant articles and documents
Oxidative chlorination, desulphonation, or decarboxylation to synthesize pharmaceutical intermediates: 2,6-Dichlorotoluene, 2,6-dichloroaniline, and 2,6-dichlorophenol
Mukhopadhyay,Chandalia
, p. 10 - 16 (1999)
An alternative manufacturing process scheme was developed for 2,6-dichlorotoluene, 2,6-dichloroaniline, and 2,6-dichlorophenol, involving oxidative chlorination after protection of the starting material in the para position followed by deprotection involving desulphonation or decarboxylation. Oxidative chlorination of 4-methylbenzenesulphonic acid, 4-methylbenzoic acid, 4-aminobenzoic acid, and 4-hydroxybenzoic acid by using HCl-H2O2, and their subsequent desulphonation or decarboxylation, gave a 60-75% yield of the desired product.
A process for preparing 2, 6 - dichloro toluene method (by machine translation)
-
Paragraph 0017-0028, (2019/01/23)
The invention discloses a method for preparing 2, 6 - dichloro toluene, in this method, 2, 3 - dichloro toluene react with chlorine to obtain 2, 3 - benzene ring chlorinated product of abnormal growth; the hydrogen gas as a reducing agent, supported palladium catalyst catalytic reduction of 2, 3 - benzene ring of abnormal growth of chlorinated product so as to obtain 2, 6 - dichloro toluene, the reaction by-product is repeated chlorinated, catalytic reduction reaction, so that the 2, 3 - dichloro toluene is transformed 2, 6 - dichloro toluene yields up to 30% or more; 2, 6 - dichloro toluene as an important chemical industry intermediate, to generate new economic value. (by machine translation)
H β molecular sieve catalytic O-chlorotoluene preparation 2, 6 - dichloro toluene method (by machine translation)
-
Paragraph 0026; 0028-0031, (2017/08/26)
The invention relates to 2, 6 - dichloro toluene preparation technology field, in particular to a molecular sieve catalyst H β of O-toluene selective chlorination of preparation 2, 6 - dichloro toluene. The invention relates to a low cost of O-toluene as the raw materials, chlorine is the chlorinating agent, H β molecular sieve as the catalyst, adopt the one-step chlorination process, catalytic O-toluene selective chlorination of preparation 2, 6 - dichloro toluene, the process is easy to operate, simple steps, low production cost, easy industrialization. (by machine translation)