42019-78-3

Basic information

• Product Name: 4-Chloro-4'-hydroxybenzophenone
• Synonyms: 4-hydroxy-4’-chloro-benophenone;LABOTEST-BB LT00248477;METHANONE, (4-CHLOROPHENYL)(4-HYDROXYPHENYL)-;4-CHLORO-4'-HYDROXYBENZOPHENONE;4-CHLORO-4-HYDROXYBENZOPHENONE;4-HYDROXY-4'-CHLOROBENZOPHENONE;(4-CHLORO-PHENYL)-(4-HYDROXY-PHENYL)-METHANONE;4-Chloro-4'-Hydroxybenzophenone 4-Hydroxy-4'-Chlorobenzophenone
• CAS NO: 42019-78-3
• Molecular Formula: C₁₃H₉ClO₂
• Molecular Weight: 232.66
• EINECS: 255-627-4
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Benzophenones & Derivatives (substituted);Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 42019-78-3.mol

Chemical Properties

• Melting Point: 177-181 °C
• Boiling Point: 257 °C (13 mmHg)
• Flash Point: 100 °C
• Appearance: light grey to beige-brown powder
• Density: 1.2082 (rough estimate)
• Refractive Index: 1.5434 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: 7.68±0.15(Predicted)
• BRN: 2049956
• CAS DataBase Reference: 4-Chloro-4'-hydroxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-4'-hydroxybenzophenone(42019-78-3)
• EPA Substance Registry System: 4-Chloro-4'-hydroxybenzophenone(42019-78-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 24/25-37/39-26-36
• Hazardous Substances Data: 42019-78-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-4'-hydroxybenzophenone is used as an impurity in the synthesis of Fenofibric acid, which is the active metabolite of fenofibrate. Fenofibrate is a medication used to treat high cholesterol and triglyceride levels. It works by increasing Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing the transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner. This helps in the management of lipid profiles and reducing the risk of cardiovascular diseases.

Preparation

Preparation by Fries rearrangement of phenyl p-chloro-benzoate, ? in the presence of aluminium chloride, without solvent, at 160° for 5 min, between 120° and 160° (good yield) or at 130° for 1 h, then at 160° for 1 h (10%) or in refluxing chlorobenzene for 10 h (52%); ? in the presence of trifluoromethanesulfonic acid at 45–55° (94%).

Synthetic route

C19H23ClO2Si → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Schlenk technique;	97%

4-chloro-4'-fluoro-benzophenone (2069-48-9) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With sodium hydroxide In water; dimethyl sulfoxide at 120℃; for 16h; Inert atmosphere; Schlenk technique;	94%
With potassium hydroxide In water; dimethyl sulfoxide at 60℃; for 18h;

4-chloro-4'-methoxybenzophenone (10547-60-1) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With hydrogen bromide; acetic acid In water at 125℃; Reagent/catalyst;	94%
With boron tribromide In tetrahydrofuran at -78 - 20℃; for 2h;	92%
With aluminum (III) chloride In toluene at 0 - 100℃; for 4h;	90%

4-n-chlorophenylacetylene (873-73-4) + p-benzoquinone (106-51-4) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With dipotassium peroxodisulfate; trifluoroacetic acid In water; acetonitrile at 25℃; for 6h; Irradiation;	90%

4-Cyanochlorobenzene (623-03-0) + phenol (108-95-2) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With hydrogenchloride; zinc(II) chloride In water; 1,2-dichloro-ethane at 90℃; for 7h; Reflux;	88.1%
Stage #1: 4-Cyanochlorobenzene; phenol With hydrogenchloride; zinc(II) chloride In 1,2-dichloro-ethane at 90℃; Stage #2: With hydrogenchloride; water In 1,2-dichloro-ethane at 20℃; for 5h; Temperature; Reflux;	88.2%

4-n-chlorophenylacetylene (873-73-4) + phenol (108-95-2) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With oxygen; copper(l) chloride In acetonitrile at 25 - 28℃; for 20h; Irradiation; regioselective reaction;	86%

4-((4-chlorophenyl)(hydroxy)methyl)phenol (164852-89-5) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With oxygen; Langlois reagent In acetonitrile at 25℃; under 760.051 Torr; for 12h; Irradiation;	76%

phenyl 4-chlorobenzoate (1871-38-1) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With aluminium trichloride for 0.0833333h;	41.3%
With aluminium trichloride

phenyl 4-chlorobenzoate (1871-38-1) → 4-chloro-4'-hydroxybenzophenone (42019-78-3) + 4'-chloro-2-hydroxybenzophenone (2985-79-7)

Conditions	Yield
With aluminium trichloride

4-amino-4'-chlorobenzophenone (4913-77-3) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With ethanol; sulfuric acid; sodium nitrite
Multi-step reaction with 2 steps 1: sodium nitrite; alcoholic sulfuric acid / Diazotization.und nachfolgenden Kochen 2: glacial acetic acid; hydrobromic acid View Scheme

4-ethoxy-4'-chloro-benzophenone (71783-49-8) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With hydrogen bromide; acetic acid

para-chlorobenzoic acid (74-11-3) + phenol (108-95-2) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With PPA

4-chloro-benzoyl chloride (122-01-0) + methoxybenzene (100-66-3) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With sodium hydroxide; aluminium trichloride 1.) dichloroethane, 50 deg C, 6 h; Multistep reaction;
With aluminium trichloride
With aluminum (III) chloride In toluene at 0℃; for 1.5h; Inert atmosphere; Reflux;

fenofibric acid sodium salt → 4-chloro-4'-hydroxybenzophenone (42019-78-3) + (4-chlorophenyl)(4-isopropoxyphenyl)methanone + 4-chloro-4'-(1-hydroxy-1-methylethyl)benzophenone

Conditions	Yield
With oxygen In methanol Product distribution; Further Variations:; Reagents; reagents conc.; photolysis; Irradiation;

4-chloro-benzoyl chloride (122-01-0) + potassium hexacyanoferrate(II) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 / nitrobenzene 2: aq. HBr; AcOH View Scheme

methoxybenzene (100-66-3) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 / nitrobenzene 2: aq. HBr; AcOH View Scheme
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere 2: aluminum (III) chloride / toluene / 2 h / 130 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 3 h / 20 °C 2: aluminum (III) chloride / toluene / 4 h / 0 - 100 °C View Scheme

fluorobenzene (462-06-6) + nitric acid sulfuric acid-water mixture → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: 45 percent / trifluoromethylsulphonic acid / 144 h 2: KOH / H2O; dimethylsulfoxide / 18 h / 60 °C View Scheme

4-chloro-benzoyl chloride (122-01-0) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: 45 percent / trifluoromethylsulphonic acid / 144 h 2: KOH / H2O; dimethylsulfoxide / 18 h / 60 °C View Scheme
Multi-step reaction with 2 steps 1: aqueous NaOH 2: AlCl3 View Scheme
Multi-step reaction with 2 steps 1: aqueous NaOH 2: AlCl3 View Scheme

phenol (108-95-2) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous NaOH 2: AlCl3 View Scheme
Multi-step reaction with 2 steps 1: aqueous NaOH 2: AlCl3 View Scheme

Phenetole (103-73-1) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: aluminium chloride; carbon disulfide 2: glacial acetic acid; hydrobromic acid View Scheme

4-chloro-benzoyl chloride (122-01-0) + phenol (108-95-2) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
aluminium chloride
aluminium chloride
Stage #1: phenol; aluminum (III) chloride In 1,2-dichloro-benzene at 30℃; for 2h; Stage #2: 4-chloro-benzoyl chloride In 1,2-dichloro-benzene at 30 - 80℃; for 5h; Stage #3: With hydrogenchloride In water; 1,2-dichloro-benzene at 30℃;

(Z)-benzaldehyde oxime (622-32-2) + (4-Chlorophenyl)(4-nitrophenyl)methanone (7497-60-1) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
In dimethyl sulfoxide

C29H17Cl5NO6Pol → C17H9Cl4F3NO4Pol + 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
With trifluoroacetic acid polystyrene ((aminomethyl)polystyrene); Product distribution / selectivity;

4-fluoroboronic acid (1765-93-1) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate / water; toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique 2: sodium hydroxide / water; dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere; Schlenk technique View Scheme

4-fluorobenzoyl chloride (403-43-0) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate / water; toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique 2: sodium hydroxide / water; dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere; Schlenk technique View Scheme

4-Chlorophenylboronic acid (1679-18-1) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate / water; toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique 2: sodium hydroxide / water; dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere; Schlenk technique View Scheme

(4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid (159191-56-7) → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate / water; toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique View Scheme

4-chloro-4'-methoxy-benzhydrylamine → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 3 steps 1: dichloromethane / 0.17 h / 0 - 20 °C 2: 2,4,6-triphenylpyrylium tetrafluoroborate / 8 h / 35 °C / Irradiation 3: boron tribromide / tetrahydrofuran / 2 h / -78 - 20 °C View Scheme

(4-chlorophenyl)(4-methoxyphenyl)methanimine → 4-chloro-4'-hydroxybenzophenone (42019-78-3)

Conditions	Yield
Multi-step reaction with 4 steps 1: sodium tetrahydroborate / methanol / 60 °C 2: dichloromethane / 0.17 h / 0 - 20 °C 3: 2,4,6-triphenylpyrylium tetrafluoroborate / 8 h / 35 °C / Irradiation 4: boron tribromide / tetrahydrofuran / 2 h / -78 - 20 °C View Scheme

4-chloro-4'-hydroxybenzophenone (42019-78-3) + ethane-1,2-dithiol (540-63-6) → 4-(2-(4-chlorophenyl)-1,3-dithiolan-2-yl)phenol

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; Inert atmosphere;	99%

1.3-propanedithiol (109-80-8) + 4-chloro-4'-hydroxybenzophenone (42019-78-3) → 4-(2-(4-chlorophenyl)-1,3-dithian-2-yl)phenol

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; Inert atmosphere;	99%

4-fluorobenzophenone (345-83-5) + 4-chloro-4'-hydroxybenzophenone (42019-78-3) → poly(ether ketone)

Conditions	Yield
Stage #1: 4-chloro-4'-hydroxybenzophenone With potassium carbonate In diphenyl sulphone at 135 - 330℃; for 5.5h; Stage #2: 4-fluorobenzophenone In diphenyl sulphone for 0.5h; Product distribution / selectivity;	96%
Stage #1: 4-chloro-4'-hydroxybenzophenone With potassium carbonate In diphenyl sulphone at 135 - 330℃; for 5.5h; Stage #2: 4-fluorobenzophenone In diphenyl sulphone for 0.5h; Product distribution / selectivity;	95%

4-chloro-4'-hydroxybenzophenone (42019-78-3) → 4-((4-chlorophenyl)(hydroxy)methyl)phenol (164852-89-5)

Conditions	Yield
With methanol; sodium tetrahydroborate at 0 - 20℃;	95%

3,6-dihydroxy-xanthen-9-one (1214-24-0) + 4-chloro-4'-hydroxybenzophenone (42019-78-3) → 3,6-bis-(4'-(4''-chlorobenzoyl)phenoxy)xanthone (123853-75-8)

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide; toluene Heating;	81.2%

2-phenylpyridine (1008-89-5) + 4-chloro-4'-hydroxybenzophenone (42019-78-3) → (4-hydroxyphenyl)(2'-(pyridin-2-yl)biphenyl-4-yl)methanone

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 1-methyl-2-phenyl-3-(diphenylphosphino)-1H-indole; potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;	81%

4,4'-(hexafluoroisopropylidene)diphenol (1478-61-1) + 4-chloro-4'-hydroxybenzophenone (42019-78-3) → 4,4'-bis[4''-(4'''-chlorobenzoyl)phenoxy](hexafluoroisopropylidene)dibenzene (389634-34-8)

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide; toluene for 3.5h; Heating;	80%

2-Adamantanone (700-58-3) + 4-chloro-4'-hydroxybenzophenone (42019-78-3) → 4-((Z)-((5S,7S)-adamantan-2-ylidene)(4-chlorophenyl)methyl)phenol

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran at -78 - 20℃; for 5h; Cooling with acetone-dry ice; Reflux;	80%

4-chloro-4'-hydroxybenzophenone (42019-78-3) + acetyl chloride (75-36-5) → 4-acetoxy-4'-chlorobenzophenone

Conditions	Yield
With triethylamine In dichloromethane at 60℃; for 15h; Inert atmosphere; Schlenk technique;	78%
With triethylamine In benzene Heating;

4-chloro-4'-hydroxybenzophenone (42019-78-3) + ethylene dibromide (106-93-4) → [4-(2-bromoethoxy)phenyl]-(4-chlorophenyl)methanone (160412-57-7)

Conditions	Yield
With potassium carbonate In acetone Heating;	75%

4-chloro-4'-hydroxybenzophenone (42019-78-3) + cyclopentanone (120-92-3) → 4-((4-chlorophenyl)(cyclopentylidene)methyl)phenol

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran for 2h; Inert atmosphere; Reflux;	74%

chloroform (67-66-3) + 4-chloro-4'-hydroxybenzophenone (42019-78-3) + acetone (67-64-1) → fenofibric acid (42017-89-0)

Conditions	Yield
Stage #1: 4-chloro-4'-hydroxybenzophenone; acetone With sodium hydroxide for 2h; Heating / reflux; Stage #2: chloroform In acetone for 8h; Heating / reflux;	73%
With sodium hydroxide
With sodium hydroxide

4-chloro-4'-hydroxybenzophenone (42019-78-3) + 3-benzoylpropionic acid methyl ester (25333-24-8) → (E)-methyl 5-(4-chlorophenyl)-5-(4-hydroxyphenyl)-4-phenylpent-4-enoate

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran at 0 - 60℃; for 3h; McMurry Reaction;	73%

4-chloro-4'-hydroxybenzophenone (42019-78-3) + 1-bromo-2,3,4-tri-O-acetyl-α-D-xylopyranose (3068-31-3) → 4-(4-chlorobenzoyl)phenyl 2,3,4-tri-O-acetyl-β-D-xylopyranoside (99482-83-4)

Conditions	Yield
With silver(l) oxide In acetonitrile for 0.5h; Ambient temperature;	72%

4-chloro-4'-hydroxybenzophenone (42019-78-3) + 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (572-09-8) → Acetic acid (2R,3R,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-[4-(4-chloro-benzoyl)-phenoxy]-tetrahydro-pyran-4-yl ester

Conditions	Yield
With silver(l) oxide In acetonitrile for 0.5h; Ambient temperature;	71%

ethyl 2-bromoisobutyrate (600-00-0) + 4-chloro-4'-hydroxybenzophenone (42019-78-3) + cholin hydroxide (123-41-1) → choline fenofibrate (856676-23-8)

Conditions	Yield
Stage #1: ethyl 2-bromoisobutyrate; 4-chloro-4'-hydroxybenzophenone With potassium carbonate at 145℃; for 3h; Stage #2: cholin hydroxide In propan-1-ol; water for 3h; Heating / reflux;	70%

dibromodifluoromethane (75-61-6) + 4-chloro-4'-hydroxybenzophenone (42019-78-3) → [4-(bromo-difluoro-methoxy)-phenyl]-(4-chloro-phenyl)-methanone (229027-51-4)

Conditions	Yield
Stage #1: 4-chloro-4'-hydroxybenzophenone With sodium hydride In N,N-dimethyl-formamide Metallation; Stage #2: dibromodifluoromethane In N,N-dimethyl-formamide Alkylation;	69%
Stage #1: With sodium hydride In N,N-dimethyl-formamide for 1.5h; Stage #2: at 20℃; for 2h; Stage #3: dibromodifluoromethane; 4-chloro-4'-hydroxybenzophenone With potassium tert-butylate at 20℃; for 16h;

4-chloro-4'-hydroxybenzophenone (42019-78-3) + acryloyl chloride (814-68-6) → (4-(acryloyloxy)phenyl)-(4-chlorophenyl)methanone

Conditions	Yield
With sodium hydroxide; tetrabutyl-ammonium chloride In dichloromethane; water at 0 - 5℃;	68.8%

Upstream product

• 71783-49-8 4-ethoxy-4'-chloro-benzophenone 
• 2069-48-9 4-chloro-4'-fluoro-benzophenone 
• 103-73-1 Phenetole 
• 52890-73-0 4-(4-chloro-benzyl)-phenol 
• 164852-89-5 4-((4-chlorophenyl)(hydroxy)methyl)phenol 
• 122-01-0 4-chloro-benzoyl chloride 
• 108-90-7 chlorobenzene 
• 60637-05-0 5-(4-chlorophenyl)-2-(4-methoxyphenyl)-2H-tetrazole 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 873-73-4 4-n-chlorophenylacetylene 
• 106-51-4 p-benzoquinone 
• 623-03-0 4-Cyanochlorobenzene 
• 856568-20-2 4-chloro-4'-methoxy-benzhydrylamine 
• 108-95-2 phenol 

Downstream Products

• 52890-73-0 4-(4-chloro-benzyl)-phenol 
• 42017-89-0 fenofibric acid 
• 22197-31-5 4-chloro-4'-hydroxybenzophenone potassium salt 
• 99482-83-4 4-(4-chlorobenzoyl)phenyl 2,3,4-tri-O-acetyl-β-D-xylopyranoside 
• 10547-60-1 4-chloro-4'-methoxybenzophenone 
• 13380-45-5 4-chlorophenyl 4-(2-pyrrolidin-1-yl-ethoxy)phenyl ketone 
• 1010071-49-4 C₂₁H₂₄BrClO₂ 
• 341525-68-6 (4-Chlorophenyl)-[4-(tetrahydropyranyloxy)phenyl]methanone 
• 341525-69-7 (4-Chlorophenyl)-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-phenyl]-methanone 
• 109553-61-9 4-chloro-4'-hydroxy-benzophenone-(2,4-dinitro-phenylhydrazone) 
• 78930-60-6 (4-chloro-phenyl)-(4-difluoromethoxy-phenyl)-methanone 
• 334931-08-7 [4-(2-bromo-1,1,2,2-tetrafluoro-ethoxy)-phenyl]-(4-chloro-phenyl)-methanone 
• 229027-51-4 [4-(bromo-difluoro-methoxy)-phenyl]-(4-chloro-phenyl)-methanone 
• 334931-09-8 (4-chloro-phenyl)-[4-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-methanone 

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An application of H-bonding interactions for directing the α-C-H oxidation of amines to amides and amino-ketones catalyzed by an organic photocatalyst is reported. The high efficiency of this method is demonstrated by the aerobic oxidation of pyrrolidines, diarylamines and benzylamines bearing urea groups with high yields and a wide substrate scope.

Preparation method of 4-chloro-4'-hydroxybenzophenone

The invention relates to a preparation method of 4-chloro-4'-hydroxybenzophenone. The preparation method comprises the following steps: adding a proper amount of dichloroethane, phenol, 4-chlorobenzonitrile, anhydrous zinc chloride and gel type strong-acid ion exchange resin into a reaction kettle and stirring; controlling temperature to 50 DEG C to 120 DEG C and continuously introducing dry hydrogen chloride gas until the 4-chlorobenzonitrile reacts completely; cooling to room temperature and adding a proper amount of a hydrochloric acid solution; raising the temperature, reflowing and reacting for 5h to 7h; then cooling to room temperature and layering; recycling the dichloroethane into an organic layer and adding alkali into residues and dissolving; de-coloring by utilizing active carbon, carrying out acid precipitation, extracting and filtering and drying to obtain the 4-chloro-4'-hydroxybenzophenone. The preparation method of the 4-chloro-4'-hydroxybenzophenone, provided by the invention, is simple in route and high in yield.