Welcome to LookChem.com Sign In|Join Free

Cas Database

674-82-8

674-82-8

Identification

  • Product Name:2-Oxetanone,4-methylene-

  • CAS Number: 674-82-8

  • EINECS:211-617-1

  • Molecular Weight:84.0746

  • Molecular Formula: C4H4O2

  • HS Code:

  • Mol File:674-82-8.mol

Synonyms:3-Butenoicacid, 3-hydroxy-, b-lactone (6CI,7CI);4-Methylene-2-oxetanone;Diketene;Ethenone, dimer;Ketene dimer;NSC 93783;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):HarmfulXn

  • Hazard Codes:Xn

  • Signal Word:Warning

  • Hazard Statement:H226 Flammable liquid and vapourH332 Harmful if inhaled

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled Fresh air, rest. Half-upright position. Refer for medical attention. In case of skin contact Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . In case of eye contact First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. If swallowed Rinse mouth. Do NOT induce vomiting. Refer for medical attention . Excerpt from ERG Guide 131P [Flammable Liquids - Toxic]: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

  • Fire-fighting measures: Suitable extinguishing media Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Fight fire from protected location or maximum possible distance. Use water spray to keep fire-exposed containers cool. Use flooding quantities of water as fog or spray. Carbon dioxide may be used. Extinguish fire using agent suitable for surrounding fire. Excerpt from ERG Guide 131P [Flammable Liquids - Toxic]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. NEVER direct water jet on liquid. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Fireproof. Separated from acids, bases and food and feedstuffs. Cooled. Dry. Store only if stabilized.Store at 32 deg F (0°C) in a standard flammable liquids storage warehouse, room, or cabinet. Special vented containers may be required. Separate from oxidizing materials, acids, and alkalies.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:Diketene
  • Packaging:50 g
  • Price:$ 300
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:Diketene
  • Packaging:25 g
  • Price:$ 200
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:Diketene
  • Packaging:10 g
  • Price:$ 100
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:Diketene
  • Packaging:5 g
  • Price:$ 60
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:Diketene
  • Packaging:100 g
  • Price:$ 590
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:ACETYLKETENE 95.00%
  • Packaging:500ML
  • Price:$ 4089.28
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:AHH
  • Product Description:Diketene 98%
  • Packaging:1000ml
  • Price:$ 538
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 7 Articles be found

SYNTHESIS OF HIGH CALORIC FUELS AND CHEMICALS

-

Paragraph 0070, (2013/05/23)

In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.

Bioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations

Nguyen, Henry,Ma, Gil,Gladysheva, Tatiana,Fremgen, Trisha,Romo, Daniel

scheme or table, p. 2 - 12 (2011/03/23)

A full account of concise, enantioselective syntheses of the anticancer agent (-)-salinosporamide A and derivatives, including (-)-homosalinosporamide, that was inspired by biosynthetic considerations is described. The brevity of the synthetic strategy stems from a key bis-cyclization of a β-keto tertiary amide, which retains optical purity enabled by A1,3-strain rendering slow epimerization relative to the rate of bis-cyclization. Optimization studies of the key bis-cyclization, enabled through byproduct isolation and characterization, are described that ultimately allowed for a gram scale synthesis of a versatile bicyclic core structure with a high degree of stereoretention. An optimized procedure for zincate generation by the method of Knochel, generally useful for the synthesis of salino A derivatives, led to dramatic improvements in side-chain attachment and a novel diastereomer of salino A. The versatility of the described strategy is demonstrated by the synthesis of designed derivatives including (-)-homosalinosporamide A. Inhibition of the human 20S and 26S proteasome by these derivatives using an enzymatic assay are also reported. The described total synthesis of salino A raises interesting questions regarding how biosynthetic enzymes leading to the salinosporamides proceeding via optically active β-keto secondary amides, are able to maintain the stereochemical integrity at the labile C2 stereocenter or if a dynamic kinetic resolution is operative.

Aktivierung der C-Cl-Bindung: Katalytische Carbonylierung von Dichlormethan und Chlorbenzol

Huser, Marc,Youinou, Marie-Therese,Osborn, John A.

, p. 1427 - 1430 (2007/10/02)

-

Preparative UV-VIS Laser Photochemistry: Photocycloadditions of Methylenelactones with Benzophenone and p-Benzoquinone. Oxygen Trapping of Paterno-Buechi Triplet 1,4-Diradicals as Model Reactions for Quinghaosu-Type 1,2,4-Trioxanes

Adam, Waldemar,Kliem, Ulrike,Lucchini, Vittorio

, p. 869 - 876 (2007/10/02)

The UV-VIS laser irradiation of 4-penten-4-olide (1) with benzophenone (BP) or with p-benzoquinone (BQ) under an argon atmosphere afforded the acetal-type oxetanes 2-BP and 2-BQ, respectively.Only for BP was the oxetane regioisomer 3-BP obtained, actually as major product, while 3-BQ appears to be photolabile under VIS-laser photolysis conditions and thus does not accumulate in sufficient amounts for detection.Under an oxygen atmosphere, besides these oxetane products also the 1,2,4-trioxanes 5-BP and 5-BQ, the oxygen trapping products of the intermediary preoxetanetriplet diradicals 12, were isolated and fully characterized.These results demonstrate that spirolactone-type 1,2,4-trioxanes as quinghaosu analogues are accessible via trapping of Paterno-Buechi triplet 1,4-diradicals by molecular oxygen.In the case of diketene as enol-lactone partner, the Paterno-Buechi reaction with BQ gave a complex product mixture even under an argon atmosphere, leading to the oxetane 6 as major product, and the spirocyclobutanone 7 and spirobioxetane 8 as minor products.Under an oxygen atmosphere also the spiroacetal 9 was obtained, but no trioxanes (oxygen trapping) could be detected in this VIS-laser photolysis.

Preparation and properties of metallacyclobutanes of nickel and palladium

Miyashita, Akira,Ohyoshi, Mayumi,Shitara, Hiroaki,Nohira, Hiroyuki

, p. 103 - 112 (2007/10/02)

Bis(phosphine)-3,3-dimethylnickela- and palladacyclobutanes have been prepared by intramolecular C-H insertion reaction of the corresponding dineopentyl metal complexes.Nickelacyclobutane complexes decompose when heated thereby undergoing competitive carb

Process route upstream and downstream products

Process route

N-(3'-methoxyphenyl)-3-oxobutanamide
25233-47-0

N-(3'-methoxyphenyl)-3-oxobutanamide

4-methyleneoxetan-2-one
674-82-8,2130-41-8

4-methyleneoxetan-2-one

Conditions
Conditions Yield
In cyclohexane; at 25 ℃; Equilibrium constant;
Ketene
463-51-4

Ketene

acetaldehyde
75-07-0,9002-91-9

acetaldehyde

4-methyleneoxetan-2-one
674-82-8,2130-41-8

4-methyleneoxetan-2-one

3-penten-2-one
625-33-2

3-penten-2-one

Conditions
Conditions Yield
Ketene
463-51-4

Ketene

acetaldehyde
75-07-0,9002-91-9

acetaldehyde

4-methyleneoxetan-2-one
674-82-8,2130-41-8

4-methyleneoxetan-2-one

3-penten-2-one
625-33-2

3-penten-2-one

Conditions
Conditions Yield
N-(3-bromo-phenyl)-3-oxo-butyramide
61579-06-4

N-(3-bromo-phenyl)-3-oxo-butyramide

4-methyleneoxetan-2-one
674-82-8,2130-41-8

4-methyleneoxetan-2-one

m-Bromoaniline
591-19-5

m-Bromoaniline

Conditions
Conditions Yield
In cyclohexane; at 25 ℃; Equilibrium constant;
Ketene
463-51-4

Ketene

4-methyleneoxetan-2-one
674-82-8,2130-41-8

4-methyleneoxetan-2-one

Conditions
Conditions Yield
With N,N,N,N,-tetramethylethylenediamine; In hexane; at -15 - -10 ℃; for 3.5h;
75%
acetone
67-64-1

acetone

4-methyleneoxetan-2-one
674-82-8,2130-41-8

4-methyleneoxetan-2-one

acetic anhydride
108-24-7

acetic anhydride

Conditions
Conditions Yield
With hydrogen; at -72 - 510 ℃; for 4h; Inert atmosphere; Sealed tube;
9-acetylcarbazole
574-39-0

9-acetylcarbazole

4-methyleneoxetan-2-one
674-82-8,2130-41-8

4-methyleneoxetan-2-one

Conditions
Conditions Yield
at 110 ℃; under 15 Torr;
dichloromethane
75-09-2

dichloromethane

carbon monoxide
201230-82-2

carbon monoxide

4-methyleneoxetan-2-one
674-82-8,2130-41-8

4-methyleneoxetan-2-one

Conditions
Conditions Yield
Pd(PCy3)2(dba); In benzene-d6; at 25 ℃; under 22501.8 Torr;
bis(triphenylphosphine)-3,3-dimethylnickelacyclobutane

bis(triphenylphosphine)-3,3-dimethylnickelacyclobutane

4-methyleneoxetan-2-one
674-82-8,2130-41-8

4-methyleneoxetan-2-one

bis(triphenylphosphine)nickel<sup>(0)</sup> dicarbonyl
13007-90-4

bis(triphenylphosphine)nickel(0) dicarbonyl

Conditions
Conditions Yield
With carbon monoxide; In toluene; High Pressure; 5 atm CO, 50°C, 1 h; pptn. of complex;
83%
8%
N-acetylphthalimide
1971-49-9

N-acetylphthalimide

4-methyleneoxetan-2-one
674-82-8,2130-41-8

4-methyleneoxetan-2-one

Conditions
Conditions Yield
at 325 ℃;

Global suppliers and manufacturers

Global( 111) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Hubei Vanz Pharm Co.,Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-27-84492310
  • Emails:sales08@vanzpharm.com
  • Main Products:88
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:55
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • EAST CHEMSOURCES LIMITED
  • Business Type:Manufacturers
  • Contact Tel:86-532-81906761
  • Emails:josen@eastchem-cn.com
  • Main Products:97
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 674-82-8
Post Buying Request Now
close
Remarks: The blank with*must be completed