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Cas Database

75-31-0

75-31-0

Identification

  • Product Name:Isopropylamine

  • CAS Number: 75-31-0

  • EINECS:200-860-9

  • Molecular Weight:59.1112

  • Molecular Formula: C3H9N

  • HS Code:

  • Mol File:75-31-0.mol

Synonyms:2-Propanamine;1-Methylethylamine;2-Aminopropane;2-Isopropylamine;2-Propylamine;Monoisopropylamine;NSC 62775;Propan-2-ylamine;sec-Propylamine;

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Safety information and MSDS view more

  • Pictogram(s):HighlyF+,IrritantXi

  • Hazard Codes: F+:Highly flammable;

  • Signal Word:Danger

  • Hazard Statement:H224 Extremely flammable liquid and vapourH315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. In case of skin contact First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention . In case of eye contact Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention. If swallowed Rinse mouth. Give nothing to drink. Do NOT induce vomiting. Refer immediately for medical attention. Inhalation causes nose and throat irritation, severe coughing, and chest pain due to irritation of air passages; can cause lung edema and loss of consciousness. Ingestion causes nausea, salivation and severe irritation of mouth and stomach. Contact with eyes causes severe irritation and possible edema of the cornea. Contact with skin causes severe irritation. (USCG, 1999) Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/

  • Fire-fighting measures: Suitable extinguishing media This chemical is a flammable liquid. Poisonous gases including nitrogen oxides and hydrogen cyanide are produced in fire. Use dry chemical, carbon dioxide, or foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any digns of deforming), withdraw immediately to a secure position. Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fire. Behavior in Fire: Burning isopropylamine is difficult to control because of the ease of reignition of the vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Containers may explode. (USCG, 1999) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Evacuate danger area! Remove all ignition sources. Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Well closed. Fireproof. Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. See Chemical Dangers. Store in an area without drain or sewer access.Isopropylamine should be stored in a cool, dry, well-ventilated area in tightly sealed containers that are labeled in accordance with OSHA's Hazard Communication Standard [29 CFR 1910.1200]. Containers of isopropylamine should be protected from physical damage and should be stored separately from strong acids, strong oxidizers, perchloryl fluoride, or 1-chloro-1,3- epoxypropane.

  • Exposure controls/personal protection:Occupational Exposure limit valuesNIOSH questions whether the PELs proposed for isopropylamine [TWA 5 ppm, STEL 10 ppm] are adequate to protect workers from recognized health hazards.Biological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 102 Articles be found

Falle,Sargent

, p. 3401,3407 (1974)

Development and Application of Efficient Ag-based Hydrogenation Catalysts Prepared from Rice Husk Waste

Unglaube, Felix,Kreyenschulte, Carsten Robert,Mejía, Esteban

, p. 2583 - 2591 (2021/04/09)

The development of strategies for the sustainable management and valorization of agricultural waste is of outmost importance. With this in mind, we report the use of rice husk (RH) as feedstock for the preparation of heterogeneous catalysts for hydrogenation reactions. The catalysts were prepared by impregnating the milled RH with a silver nitrate solution followed by carbothermal reduction. The composition and morphology of the prepared catalysts were fully assessed by IR, AAS, ICP-MS, XPS, XRD and STEM techniques. This novel bio-genic silver-based catalysts showed excellent activity and remarkable selectivity in the hydrogenation of nitro groups in both aromatic and aliphatic substrates, even in the presence of reactive functionalities like halogens, carbonyls, borate esters or nitriles. Recycling experiments showed that the catalysts can be easily recovered and reused multiple times without significant drop in performance and without requiring re-activation.

Rapid and Quantitative Profiling of Substrate Specificity of ω-Transaminases for Ketones

Han, Sang-Woo,Shin, Jong-Shik

, p. 3287 - 3295 (2019/06/21)

ω-Transaminases (ω-TAs) have gained growing attention owing to their capability for asymmetric synthesis of chiral amines from ketones. Reliable high-throughput activity assay of ω-TAs is essential in carrying out extensive substrate profiling and establishing a robust screening platform. Here we report spectrophotometric and colorimetric methods enabling rapid quantitation of ω-TA activities toward ketones in a 96-well microplate format. The assay methods employ benzylamine, a reactive amino donor for ω-TAs, as a cosubstrate and exploit aldehyde dehydrogenase (ALDH) as a reporter enzyme, leading to formation of benzaldehyde detectable by ALDH owing to concomitant NADH generation. Spectrophotometric substrate profiling of two wild-type ω-TAs of opposite stereoselectivity was carried out at 340 nm with 22 ketones, revealing subtle differences in substrate specificities that were consistent with docking simulation results obtained with cognate amines. Colorimetric readout for naked eye detection of the ω-TA activity was also demonstrated by supplementing the assay mixture with color-developing reagents whose color reaction could be quantified at 580 nm. The colorimetric assay was applied to substrate profiling of an engineered ω-TA for 24 ketones, leading to rapid identification of reactive ketones. The ALDH-based assay is expected to be promising for high-throughput screening of enzyme collections and mutant libraries to fish out the best ω-TA candidate as well as to tailor enzyme properties for efficient amination of a target ketone.

A hydrogenation of acetone ammonia synthesis isopropylamine method (by machine translation)

-

Paragraph 0030; 0031; 0032; 0033; 0034; 0035; 0036-0040, (2017/03/14)

The invention discloses a method for hydrogenation of acetone ammonia synthesis isopropylamine method, the reaction feeding before replace the nitrogen in the reactor of the air, and then the preheating of the hydrogen is introduced in the reactor, the catalyst in the reactor temperature is raised to 90 - 180 °C, in the reactor pressure to rise to 0.2 - 1.8 mpa; after preheating into acetone, hydrogen, and ammonia are mixed in the material into the reactor, the catalyst in the presence of 0.2 - 1.8 mpa, 90 - 180 °C hydrogenated ammoniation reaction, to get the crude product, prepared by precipitating the crude product after cooling separator for separating gas and liquid, liquid is rough isopropylamine. The invention make coarse isopropylamine in isopropylamine content is high, acetone conversion rate 100%, isopropylamine selectively in 99.7% or more. (by machine translation)

Process route upstream and downstream products

Process route

hydrogenchloride
7647-01-0,15364-23-5

hydrogenchloride

<i>N</i>-isopropyl-thiobenzimidic acid benzyl ester

N-isopropyl-thiobenzimidic acid benzyl ester

benzyl benzothioate
13402-51-2

benzyl benzothioate

isopropylamine
75-31-0

isopropylamine

phenylmethanethiol
100-53-8

phenylmethanethiol

Conditions
Conditions Yield
acetone
67-64-1

acetone

benzylamine
100-46-9

benzylamine

benzaldehyde
100-52-7

benzaldehyde

isopropylamine
75-31-0

isopropylamine

Conditions
Conditions Yield
With S-selective ω-transaminase from paracoccus denitrificans transaminase; NAD; aldehyde dehydrogenase; In dimethyl sulfoxide; Reagent/catalyst; Enzymatic reaction;
piperazine
110-85-0

piperazine

2-Amino-1-propanol
6168-72-5

2-Amino-1-propanol

N-(1-aminomethyl-2-hydroxyethyl)amine
2811-20-3

N-(1-aminomethyl-2-hydroxyethyl)amine

(RS)-2-methylpiperazine
109-07-9

(RS)-2-methylpiperazine

isopropylamine
75-31-0

isopropylamine

1,2-diaminopropan
78-90-0,10424-38-1

1,2-diaminopropan

3-amino-2-propanol
78-96-6,1674-56-2

3-amino-2-propanol

methylamine
74-89-5

methylamine

Conditions
Conditions Yield
With ammonia; hydrogen; catalyst obtained by prereduction from precursor whose catalytically active composition before the reduction with hydrogen comprised 13% by weight of Cu, calculated as CuO, 28% by weight of NI, calculated as NiO, 28% by weight of Co, calculated as CoO and 31% by weight of Zr, calculated as ZrO2; In water; at 250 ℃; under 37503.8 - 225023 Torr; Product distribution / selectivity; Autoclave;
Isopropyl-thiocarbamic acid; compound with isopropylamine
64221-22-3

Isopropyl-thiocarbamic acid; compound with isopropylamine

1,3-diisopropylurea
4128-37-4

1,3-diisopropylurea

carbon oxide sulfide
463-58-1

carbon oxide sulfide

isopropylamine
75-31-0

isopropylamine

Conditions
Conditions Yield
at 148 ℃; Thermodynamic data; ΔS(excit.)=-98,94; E*;
C<sub>12</sub>H<sub>15</sub>N
1608182-11-1

C12H15N

isopropylamine
75-31-0

isopropylamine

2-indanone
615-13-4

2-indanone

Conditions
Conditions Yield
In dimethylsulfoxide-d6; Solvent; Equilibrium constant;
1-hydroxy-2-propanone oxime
134252-16-7

1-hydroxy-2-propanone oxime

2-Amino-1-propanol
6168-72-5

2-Amino-1-propanol

isopropylamine
75-31-0

isopropylamine

Conditions
Conditions Yield
With sodium amalgam; acetic acid;
isopropylamine
75-31-0

isopropylamine

Conditions
Conditions Yield
2-nitropropane
79-46-9

2-nitropropane

isopropylamine
75-31-0

isopropylamine

N-isopropylhydroxyamine
5080-22-8

N-isopropylhydroxyamine

Conditions
Conditions Yield
With hydrogen; In para-xylene; isopropyl alcohol; at 25 ℃; for 4h; under 760.051 Torr;
88%
9%
3-(3,5-dichloro-phenyl)-ureidoacetic acid
62584-33-2

3-(3,5-dichloro-phenyl)-ureidoacetic acid

isopropylamine
75-31-0

isopropylamine

3,5-Dichloroaniline
626-43-7

3,5-Dichloroaniline

3-(3',5'-Dichlorophenyl)imidazolidine-2,4-dione
27387-87-7

3-(3',5'-Dichlorophenyl)imidazolidine-2,4-dione

Conditions
Conditions Yield
With Pseudomonas fluoerescens; water; In various solvent(s); at 30 ℃; for 200h; pH=6.5; Further Variations:; Reagents; Kinetics; Microbiological reaction;
γ-L-glutamylisopropylamide
4311-12-0

γ-L-glutamylisopropylamide

isopropylamine
75-31-0

isopropylamine

Conditions
Conditions Yield
With recombinant Pseudomonas nitroreducens IFO12694 γ-glutamyltranspeptidase; at 30 ℃; for 0.0333333h; pH=10.5; aq. buffer; Enzymatic reaction;

Global suppliers and manufacturers

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  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
  • Main Products:110
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:56
  • Country:China (Mainland)
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