76-13-1

Basic information

• Product Name: 1,1,2-Trichlorotrifluoroethane
• Synonyms: 1,1,2-Trichloro-1,2,2-trifluoroethane;Arcton 113;Arklone P;Asahifron 113;CFC 113;Daiflon 113;Delifrene 113;Delifrene LS;FC 113;FKW 113;Fluorocarbon 113;Forane 113;Freon 113;Freon 113TR-T;Freon TF;Freon TS;Fridohna;Frigen 113;Frigen 113A;Frigen 113TR-N;Fron 113;Fronsolve113;Genetron 113;Halon 113;Isceon 113;Khladon 113;Ledon113;R 113;Refrigerant 113;Refrigerant R 113
• CAS NO: 76-13-1
• Molecular Formula: C₂Cl₃F₃
• Molecular Weight: 187.3756096
• EINECS: 200-936-1
• Mol File: 76-13-1.mol
• Article Data: 27

Chemical Properties

• Melting Point: -36.4℃
• Boiling Point: 50.9 °C at 760 mmHg
• Flash Point: 195°C
• Appearance: Colorless liquid with a sweet, ether-like odor
• Density: 1.67 g/cm³
• Refractive Index: nD20:1.3578
• Water Solubility: 0.02 g/100 mL. Slightly soluble
• CAS DataBase Reference: 1,1,2-Trichlorotrifluoroethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,2-Trichlorotrifluoroethane(76-13-1)
• EPA Substance Registry System: 1,1,2-Trichlorotrifluoroethane(76-13-1)

Safety Data

• Hazard Codes: N:Dangerous for the enviro
• Statements: R52/53:; R59:
• Safety Statements: S59:; S61:
• Hazardous Substances Data: 76-13-1(Hazardous Substances Data)

Usage

General Description

1,1,2-Trichlorotrifluoroethane, also known as CFC-113, is a type of chlorofluorocarbon (CFC) that was primarily used as a refrigerant and as a cleaning agent in the electronics industry. It is a colorless, nonflammable liquid with a sweet, chloroform-like odor. It is a potent ozone-depleting chemical and its production has been largely phased out since the late 20th century due to environmental concerns. Prolonged exposure or large quantities can pose health risks, including respiratory and neurological complications. Its chemical formula is C2Cl3F3.

InChI:InChI=1/C2Cl3F3/c3-1(4,6)2(5,7)8

Synthetic route

hexachloroethane (67-72-1) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With aluminum(III) fluoride; hydrogen fluoride at 120℃; under 11251.1 Torr; for 10h; Reagent/catalyst; Temperature; Autoclave;	97.06%
With CFC-112a; antimonypentachloride; fluorine at 32℃; unter vermindertem Druck;
With antimonypentachloride; antimony(III) fluoride at 48℃;

1,2,2-trifluorodichloroethanesulfonyl chloride (7740-58-1) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + sulfur dioxide (7446-09-5)

Conditions	Yield
200°C, 7 days;	A 97% B 97%
100°C, 7 days;	A 19% B 18%

Chlorotrifluoroethylene (79-38-9) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With benzophenone; chlorine at -80℃;	92%

CFC-112a (76-12-0) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With bromine trifluoride; antimonypentachloride In 1,1,2-Trichloro-1,2,2-trifluoroethane at 20 - 25℃;	90%
With chromium(III) oxyfluoride; hydrogen fluoride at 500℃;

Chlorotrifluoroethylene (79-38-9) + chloro(trifluoromethyl)disulfane (53268-50-1) → 2,2-dichlorotrifluoroethyl(trifluoromethyl)disulfane (55882-11-6) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + bis(trifluoromethyl)tetrasulfide (372-07-6) + 1,2-dichlorotrifluoroethyl(trifluoromethyl)disulfane (55882-10-5)

Conditions	Yield
Irradiation (UV/VIS);	A n/a B n/a C n/a D 80%
Irradiation (UV/VIS);	A n/a B n/a C n/a D 80%

1,2-dichlorotetrafluorocyclopropane (695-50-1) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + 1,3-dichloro-1,2,2,3-tetrafluoro-1,3-diiodo-propane

Conditions	Yield
With iodine at 140 - 165℃; for 4h;	A n/a B 63%

Trichloroethylene (79-01-6) → 1,2,2-trichloro-1,2-difluoroethane (354-15-4) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With hydrogen fluoride; fluorine In trichlorofluoromethane at -70℃; for 4h; Product distribution / selectivity; Inert atmosphere;	A 50% B 18%

Chlorotrifluoroethylene (79-38-9) + sulfur bis(trifluoromethyl)amide chloride (1768-32-7) → 2,4-dichlorohexafluorothiolane (34994-73-5) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + N,N-bistrifluoromethyl-2,2-dichlorotrifluoroethanesulfenamide (81619-76-3) + S-(1,2-Dichloro-1,2,2-trifluoro-ethyl)-N,N-bis-trifluoromethyl-thiohydroxylamine

Conditions	Yield
for 528h; Irradiation; Further byproducts given;	A 11% B 16% C 31% D 31%

Chlorotrifluoroethylene (79-38-9) + sulfur bis(trifluoromethyl)amide chloride (1768-32-7) → 1,1,3,4-Tetrachlorohexafluorobutane (423-38-1) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + N,N-bistrifluoromethyl-2,2-dichlorotrifluoroethanesulfenamide (81619-76-3) + S-(1,2-Dichloro-1,2,2-trifluoro-ethyl)-N,N-bis-trifluoromethyl-thiohydroxylamine

Conditions	Yield
for 528h; Irradiation; Further byproducts given;	A 6.5% B 16% C 31% D 31%

Chlorotrifluoroethylene (79-38-9) + sulfur bis(trifluoromethyl)amide chloride (1768-32-7) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + sulfur bis{bis(trifluoromethyl)amide} (1913-85-5) + N,N-bistrifluoromethyl-2,2-dichlorotrifluoroethanesulfenamide (81619-76-3) + S-(1,2-Dichloro-1,2,2-trifluoro-ethyl)-N,N-bis-trifluoromethyl-thiohydroxylamine

Conditions	Yield
for 528h; Irradiation; Further byproducts given;	A 16% B 15% C 31% D 31%

Chlorotrifluoroethylene (79-38-9) + sulfur bis(trifluoromethyl)amide chloride (1768-32-7) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + N,N-bistrifluoromethyl-2,2-dichlorotrifluoroethanesulfenamide (81619-76-3) + S-(1,2-Dichloro-1,2,2-trifluoro-ethyl)-N,N-bis-trifluoromethyl-thiohydroxylamine + S-[2-(Bis-trifluoromethyl-amino)-1-chloro-1,2,2-trifluoro-ethyl]-N,N-bis-trifluoromethyl-thiohydroxylamine

Conditions	Yield
for 528h; Irradiation; Further byproducts given;	A 16% B 31% C 31% D 4%

Chlorotrifluoroethylene (79-38-9) + sulfur bis(trifluoromethyl)amide chloride (1768-32-7) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + disulfur bis{bis(trifluoromethyl)amide} (2714-58-1) + N,N-bistrifluoromethyl-2,2-dichlorotrifluoroethanesulfenamide (81619-76-3) + S-(1,2-Dichloro-1,2,2-trifluoro-ethyl)-N,N-bis-trifluoromethyl-thiohydroxylamine

Conditions	Yield
for 528h; Irradiation; Further byproducts given;	A 11% B 12% C 26% D 26%

Chlorotrifluoroethylene (79-38-9) + α-chlorocarbonylhexafluoroisopropylsulfenyl chloride (93460-12-9) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + bis-(α-chlorocarbonylhexafluoroisopropyl) disulfide (83235-80-7) + 2,2-dichlorotrifluoroethyl 1-chlorocarbonylhexafluoroisopropyl sulfide

Conditions	Yield
at 150 - 160℃; for 10h;	A n/a B n/a C 21%

1,1,2,2-tetrachloroethylene (127-18-4) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With hydrogen fluoride; antimonypentachloride at 75 - 100℃;
With antimony (III)-antimony (V)-fluoro chloride ene; hydrogen fluoride; chlorine at 160 - 165℃; unter Druck;
With zirconium(IV) fluoride; hydrogen fluoride at 350 - 360℃;

1,1-difluorotetrachloroethane (76-11-9) → 1,1,1-Trichloro-2,2,2-trifluoroethane (354-58-5) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With hydrogen fluoride; pyrographite; lithium fluoride at 375 - 550℃;

1,1,1,2-tetrachoroethane (630-20-6) → 1,2-dichloro-1,1,2,2-tetrafluoroethane (76-14-2) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With antimony (III)-antimony (V)-fluoro chloride; hydrogen fluoride; chlorine at 160 - 165℃; unter Druck;
With antimony (III)-antimony (V)-fluoro chloride; hydrogen fluoride; chlorine at 160 - 165℃; unter Druck;
With antimony (III)-antimony (V)-fluoro chloride; hydrogen fluoride; chlorine at 160 - 165℃; unter Druck;

1,1,1-trichloro-2,2-difluoroethane (354-12-1) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With hydrogen fluoride; antimonypentachloride at 125℃;

Trichloroethylene (79-01-6) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With nitrogen; copper; fluorine at 70℃;

F121a (354-11-0) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With hydrogen fluoride; antimonypentachloride at 125℃;

hexachloroethane (67-72-1) → 1,2-dichloro-1,1,2,2-tetrafluoroethane (76-14-2) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With antimony (III)-antimony (V)-fluoro chloride; hydrogen fluoride; chlorine at 160 - 165℃; unter Druck;
With antimony (III)-antimony (V)-fluoro chloride; hydrogen fluoride; chlorine at 160 - 165℃; unter Druck;
With antimony (III)-antimony (V)-fluoro chloride; hydrogen fluoride; chlorine at 160 - 165℃; unter Druck;

1,2-dichloro-1,2-difluoroethene (598-88-9) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With fluorine at 0℃;
With sulfur tetrafluoride; hydrogen fluoride; chlorine at 20℃; for 10h; Yield given;

Trichloroethylene (79-01-6) → 1,2-dichloro-1,2,2-trifluoroethane (354-23-4) + 1,1-dichloro-1,2,2-trifluoroethane (812-04-4) + 1,2,2-trichloro-1,2-difluoroethane (354-15-4) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1)

Conditions	Yield
With manganese(III) fluoride at 120℃;
With manganese(III) fluoride at 220℃;

Trichloroethylene (79-01-6) → 1,2-dichloro-1,2,2-trifluoroethane (354-23-4) + 1,2,2-trichloro-1,2-difluoroethane (354-15-4) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + CFC-112a (76-12-0)

Conditions	Yield
With cobalt (III) fluoride at 120℃; Further byproducts given;

Trichloroethylene (79-01-6) → 1,1,1-trifluoro-2-chloroethane (75-88-7) + 1,2,2-trichloro-1,2-difluoroethane (354-15-4) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + CFC-112a (76-12-0)

Conditions	Yield
With cobalt (III) fluoride at 120℃; Further byproducts given;

Trichloroethylene (79-01-6) → 1,1-dichloro-1,2,2-trifluoroethane (812-04-4) + 1,2,2-trichloro-1,2-difluoroethane (354-15-4) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + CFC-112a (76-12-0)

Conditions	Yield
With cobalt (III) fluoride at 120℃; Further byproducts given;

Chlorotrifluoroethylene (79-38-9) → 1,2-Dinitro-1-chlortrifluoraethan (425-11-6) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + chlorodifluoroacetyl fluoride (354-27-8) + 1,2-dichloro-1,2,2-trifluoronitrosoethane (354-71-2)

Conditions	Yield
With nitrogen(II) oxide; iron(III) chloride Further byproducts given;

Chlorotrifluoroethylene (79-38-9) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + 1,2-dichloro-1,2,2-trifluoro-1-iodoethane (354-61-0) + 1,1-Dichloro-2-iodotrifluoroethane (661-66-5)

Conditions	Yield
With Iodine monochloride

Chlorotrifluoroethylene (79-38-9) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + chlorodifluoroacetyl fluoride (354-27-8) + 1,2-dichloro-1,2,2-trifluoronitrosoethane (354-71-2)

Conditions	Yield
With nitrogen(II) oxide; iron(III) chloride

Chlorotrifluoroethylene (79-38-9) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + chlorodifluoroacetyl fluoride (354-27-8) + 1,2-dichloro-1,2,2-trifluoronitrosoethane (354-71-2) + 2-nitro-1,1-dichlorotrifluoroethane (1717-62-0)

Conditions	Yield
With nitrogen(II) oxide; iron(III) chloride Further byproducts given;

Chlorotrifluoroethylene (79-38-9) → 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + chlorodifluoroacetyl fluoride (354-27-8) + 1,2-dichloro-1,2,2-trifluoronitrosoethane (354-71-2) + 1-chloro-1,2,2-trifluoro-2-nitro-1-nitroso-ethane (755-62-4)

Conditions	Yield
With nitrogen(II) oxide; iron(III) chloride Further byproducts given;

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → Chlorotrifluoroethylene (79-38-9)

Conditions	Yield
With potassium zinc trihydride at 250 - 320℃; under 7500.75 Torr; for 5h; Temperature; Pressure; Inert atmosphere; Large scale;	99.22%
With ammonium chloride; zinc(II) chloride In methanol; water electrochemical process;	90%
With zinc(II) chloride; zinc In ethanol at 50℃; for 3h; Dehalogenation;	75%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + 1,3,3,3-tetrafluoro-1-methoxy-2-trifluoromethyl-propene (360-53-2) → C6H3F9O

Conditions	Yield
at 120℃; for 2.5h;	98%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + malononitrile (109-77-3) → dimethyl 1,3-propanediimidate dihydrochloride (71160-05-9)

Conditions	Yield
In hydrogenchloride; methanol	96%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → 1,2-dichloro-1,2,2-trifluoroethane (354-23-4) + Chlorotrifluoroethylene (79-38-9) + 1,1,2-trifluoroethylene (359-11-5)

Conditions	Yield
With hydrogen; silica gel; nickel at 450℃; under 760 Torr; Title compound not separated from byproducts;	A n/a B 95.8% C n/a
bismuth(III) chloride; silica gel; palladium at 250℃; Yield given. Yields of byproduct given;
With hydrogen; silica gel; nickel at 450℃; under 760 Torr; Product distribution; other supported Ni catalysts and metal oxides;
bismuth(III) chloride; silica gel; palladium at 250℃; under 760 Torr; Product distribution; other catalysts and modifier; variation of condition: selectivity;

1-Heptene (592-76-7) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → 1,1-Dichloro-1,2,2-trifluoro-nonane (129277-71-0)

Conditions	Yield
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 40℃; for 4h;	88.5%

1-hexene (592-41-6) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → 1,1-Dichloro-1,2,2-trifluoro-octane (129277-70-9)

Conditions	Yield
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 40℃; for 3h; other alkenes and alkynes;	86.5%
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 40℃; for 3h;	86.5%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + sodium thiophenolate (930-69-8) → 2-chloro-1,1,2-trifluoro-1-(phenyl thio) ethane (91122-75-7) + <(2,2-dichloro-1,1,2-trifluoroethyl)thio>benzene (91122-73-5) + diphenyldisulfane (882-33-7)

Conditions	Yield
In dimethyl sulfoxide for 0.5h; Product distribution; Mechanism; Ambient temperature; various per(chloro,fluoro)ethanes and conditions;	A 0.9 % Chromat. B 86% C 3 % Chromat.
In dimethyl sulfoxide for 0.5h; Ambient temperature;	A 0.9 % Chromat. B 86% C 3 % Chromat.
In water; dimethyl sulfoxide for 48h; Ambient temperature;	A 18 % Chromat. B 16 % Chromat. C 38 % Chromat.

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + 9H-carbazole (86-74-8) → 1-(2,2-dichlorotrifluoroethyl)carbazole

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 30 - 35℃; for 0.833333h;	84%

indole (120-72-9) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → 1-(2,2-dichlorotrifluoroethyl)indole

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 40 - 45℃; for 0.5h;	81%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + diphenylamine (122-39-4) → N-(2,2-dichlorotrifluoroethyl)diphenylamine

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 45 - 50℃; for 0.5h;	81%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → 1,2-dichloro-1,2,2-trifluoroethane (354-23-4)

Conditions	Yield
With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃;	80%
With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃; Product distribution; Mechanism; also with further polyhalofluoroalkanes;	80%
Irradiation;
With water; sodium formate; titanium(IV) oxide Mechanism; Ambient temperature; Irradiation;

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + cyclohexene (110-83-8) → (2,2-Dichloro-1,1,2-trifluoro-ethyl)-cyclohexane (129298-65-3)

Conditions	Yield
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 50℃; for 8h;	79.5%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + potassium phenolate (100-67-4) → 1-hydro-1-chloro-2-phenoxyperfluoroethane (456-62-2) + <(2,2-dichloro-1,1,2-trifluoroethyl)oxy>benzene (95519-55-4)

Conditions	Yield
In dimethyl sulfoxide for 1h; Ambient temperature; Yields of byproduct given;	A n/a B 79%
In dimethyl sulfoxide for 4h;	A 9% B 37%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + Allyl acetate (591-87-7) → Acetic acid 5,5-dichloro-4,4,5-trifluoro-pentyl ester (129277-72-1)

Conditions	Yield
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 40℃; for 2h;	78.4%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → Hexafluoroethane (76-16-4) + Chloropentafluoroethane (76-15-3) + 1,2-dichloro-1,1,2,2-tetrafluoroethane (76-14-2)

Conditions	Yield
With chromium fluoride; magnesium fluoride; hydrogen fluoride at 250 - 500℃; Product distribution;	A 3% B 78% C 19%

10H-phenothiazine (92-84-2) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → 1-(2,2-dichlorotrifluoroethyl)phenthiazine

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 40 - 45℃; for 0.666667h;	78%

2,4-Bis(methylthio)pyrimidine (5909-26-2) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → 4-chloro-2,6-bis(methylthio)pyrimidine (257957-18-9)

Conditions	Yield
Stage #1: 2,4-Bis(methylthio)pyrimidine With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex In tetrahydrofuran at -20℃; for 1h; Inert atmosphere; Stage #2: 1,1,2-Trichloro-1,2,2-trifluoroethane In tetrahydrofuran at -35 - -20℃; for 3h; Inert atmosphere; regioselective reaction;	78%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → 1,2-dichlorotrifluoroethyl fluorosulfate (681-25-4) + Cl2

Conditions	Yield
With bis(fluorosulfuryl) peroxide; antimony pentafluoride; fluorosulphonic acid at 20 - 30℃; for 0.5h;	A 75.4% B n/a

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + potassium 2-methylbutan-2-olate (41233-93-6) → 2-(2-Chloro-1,1,2-trifluoro-ethoxy)-2-methyl-butane + 2-(2,2-Dichloro-1,1,2-trifluoro-ethoxy)-2-methyl-butane (98481-69-7)

Conditions	Yield
In various solvent(s) for 1h; Ambient temperature; Yields of byproduct given;	A n/a B 75%

pyrrole (109-97-7) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → 1-(2,2-dichlorotrifluoroethyl)pyrrole

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 50 - 55℃; for 0.5h;	75%

1-hexene (592-41-6) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → 1,2-dichloro-1,1,2-trifluorooctane

Conditions	Yield
With sodium dithionite; sodium hydrogencarbonate In dimethyl sulfoxide at 60℃; for 6h;	74%
With sodium dithionite; water; sodium hydrogencarbonate In acetonitrile at 40 - 45℃; for 20h;	56%
With sodium dithionite; sodium hydrogencarbonate In acetonitrile at 40 - 45℃; for 20h;	56%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + 1-benzyl-3-hydroxy-1H-indazole (2215-63-6) → 1-benzyl-3-(2,2-dichloro-1,1,2-trifluoroethoxy)-1H-indazole (1300727-50-7)

Conditions	Yield
Stage #1: 1-benzyl-3-hydroxy-1H-indazole With potassium tert-butylate In tert-butyl alcohol at 20℃; for 2h; Stage #2: 1,1,2-Trichloro-1,2,2-trifluoroethane In N,N-dimethyl-formamide at 100℃; for 48h;	74%

1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + 1,7-Octadiene (3710-30-3) → 10,10-Dichloro-9,9,10-trifluoro-dec-1-ene (129277-76-5)

Conditions	Yield
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 45℃; for 4h;	72.5%

NH-pyrazole (288-13-1) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) → 1-(2,2-dichlorotrifluoroethyl)pyrazole (909416-36-0)

Conditions	Yield
With sodium hydride; tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 50 - 55℃; for 2h;	72%

tetramethylorthosilicate (681-84-5) + 1,1,2-Trichloro-1,2,2-trifluoroethane (76-13-1) + p-trifluoromethylphenyl bromide (402-43-7) + argon → trimethoxy(4-(trifluoromethyl)phenyl)silane (35692-32-1)

Conditions	Yield
With n-butyllithium In diethyl ether; hexane	72%

Upstream product

• 127-18-4 1,1,2,2-tetrachloroethylene 
• 79-01-6 Trichloroethylene 
• 79-38-9 Chlorotrifluoroethylene 
• 75-71-8 Dichlorodifluoromethane 
• 374-07-2 1,1-dichlorotetrafluoroethane 
• 76-14-2 1,2-dichloro-1,1,2,2-tetrafluoroethane 
• 1768-32-7 sulfur bis(trifluoromethyl)amide chloride 
• 93460-12-9 α-chlorocarbonylhexafluoroisopropylsulfenyl chloride 
• 56-23-5 tetrachloromethane 
• 75-09-2 dichloromethane 
• 67-66-3 chloroform 
• 75-35-4 1,1-Dichloroethylene 
• 79-34-5 1,1,2,2-tetrachloroethane 
• 598-88-9 1,2-dichloro-1,2-difluoroethene 

Downstream Products

• 76-11-9 1,1-difluorotetrachloroethane 
• 67-72-1 hexachloroethane 
• 430-66-0 1,1,2-Trifluoroethan 
• 75-69-4 trichlorofluoromethane 
• 76-16-4 Hexafluoroethane 
• 76-15-3 Chloropentafluoroethane 
• 374-07-2 1,1-dichlorotetrafluoroethane 
• 76-14-2 1,2-dichloro-1,1,2,2-tetrafluoroethane 
• 79-38-9 Chlorotrifluoroethylene 
• 354-58-5 1,1,1-Trichloro-2,2,2-trifluoroethane 
• 354-21-2 1,1,2-trichloro-2,2-difluoroethane 
• 50994-70-2 1-bromo-1,1,2-trichloro-2,2-difluoro-ethane 
• 359-29-5 trichlorofluoroethene 
• 677-48-5 1,1,2-trichloro-2,2-difluoro-1-iodo-ethane 

Relevant articles and documents

Method for synthesizing 4 -halo -1, 1 and 2 -trifluoro -1 -butene (by machine translation)

The invention discloses a method for synthesizing 4 -halo -1, 1 and 2 -trifluoro -1 -butene. , Polyhaloethane is synthesized by reaction of chlorotrifluoroethylene with halogen, and then polyhalogenated ethane is reacted with ethylene under the action of a catalyst to synthesize polyhalogenated butane, and finally, 4 - halogenated -1, 1 and 2 -trifluoro -1 -butene are dehalogenated under the action of a reducing agent. The method has the characteristics of simple synthesis method, high product purity and low preparation cost. (by machine translation)

PROCESS FOR THE FLUORINATION OF HALOOLEFINS

A process for the fluorination of haloolefins with elemental fluorine in the presence of anhydrous HF proceeds with high yield and selectivity in the product deriving from the addition of fluorine to the carbon-carbon double bond.

PROCESS FOR THE PRODUCTION OF 1,1,1,3,3,3-HEXAFLUOROPROPANE

A process for the preparation of 1,1,1,3,3,3-hexafluoropropane is disclosed. The process involves (a) contacting at least one halopropane of the formula CF3CH2CHyX3-y (where each X is independently F, Cl or Br, and y is 3, 2, or 1) with Cl?2#191 in the presence of light or a free radical initiator to produce a mixture comprising CF3CH2CCIyX3-y; (b) contacting the CF3CH2CCIyX3-y produced in step (a) with HF, optionally in the presence of a fluorination catalyst, to produce a product mixture comprising CF3CH2CF3; and (c) recovering CF3CH2CF3 from the mixture produced in step (b).