563-47-3 Usage
Description
3-Chloro-2-methylpropene is used as an intermediate to produce carbofuran, herbicides, plastics, pharmaceuticals and other organics. It is also used as an additive in textile and perfumes. It was used to study ring opening polymerization of oxirane derivatives using organotin phosphate condensate and cationic polymerization of 3-Chloro-2-methylpropene with AICI3 and AIBr3 as initiators. It is also the reactant for the synthesis of cyclobutanone.
Chemical Properties
clear liquid
Uses
Different sources of media describe the Uses of 563-47-3 differently. You can refer to the following data:
1. 3-Chloro-2-methylpropene has been used as reactant in the synthesis of cyclobutanone. It is used as an intermediate in the production of plastics, pharmaceuticals and other organic chemicals.
2. 3-Chloro-2-methyl-1-propene was used to study ring opening polymerization of oxirane derivatives using organotin phosphate condensate. It was used to study cationic polymerization of 3-Chloro-2-methyl-1-propene using using AICI3 and A3IBr, as initiators.
Biological Functions
MAC is a valuable index for clinical anesthesia, but it is
seldom employed without taking other factors into consideration.
For example, inhibiting movement in only
50% of patients is not acceptable. Consequently, if an
inhalational agent were being used alone—that is, without
the administration of other anesthetics or analgesic
drugs—the anesthesiologist would employ a multiple of
its MAC value to ensure immobility.MAC is frequently
multiplied by a factor of 1.3 to achieve nearly 100%
clinical efficacy. On the other hand, useful clinical results
may be achieved with doses of anesthetics below
MAC levels. For example, mild analgesia and amnesia
often occur with doses of inhalational agents that are
near 0.5 MAC. In this state, it may even be possible to
communicate with patients intraoperatively, while their
recall is limited.
Synthesis Reference(s)
The Journal of Organic Chemistry, 46, p. 824, 1981 DOI: 10.1021/jo00317a041
General Description
A colorless to straw-colored liquid with a sharp penetrating odor. Less dense than water and insoluble in water. Flash point below 0°F. May be toxic by ingestion. Irritating to skin and eyes. Used to make plastics and pharmaceuticals.
Air & Water Reactions
Highly flammable. 3-Chloro-2-methylpropene may react with water at elevated temperatures. . Insoluble in water.
Reactivity Profile
3-Chloro-2-methylpropene is sensitive to light. 3-Chloro-2-methylpropene can react vigorously with oxidizers. 3-Chloro-2-methylpropene is incompatible with strong bases. 3-Chloro-2-methylpropene may react with water at elevated temperatures. .
Hazard
Irritant; poison; anesthetic; questionable
carcinogen; toxic.
Health Hazard
Inhalation causes irritation of nose and throat. Contact of vapor or liquid with eyes causes irritation. Liquid irritates skin. Ingestion causes irritation of mouth and stomach.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data.
Experimental reproductive effects. An
irritant. Human mutation data reported.
Very dangerous fire hazard when exposed to
heat, flame, or oxidizers. Moderately
explosive when exposed to heat or flame.
Can react vigorously with oxidizing
materials. To fight fire, use alcohol foam,
CO2, dry chemical. When heated to
decomposition it emits toxic fumes of Cl-.
See also CHLORINATED
HYDROCARBONS, ALIPHATIC; and
ALLYL COMPOUNDS.
Carcinogenicity
3-Chloro-2-methylpropene is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Check Digit Verification of cas no
The CAS Registry Mumber 563-47-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,6 and 3 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 563-47:
(5*5)+(4*6)+(3*3)+(2*4)+(1*7)=73
73 % 10 = 3
So 563-47-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H7Cl/c1-4(2)3-5/h1,3H2,2H3
563-47-3Relevant articles and documents
METHOD FOR PREPARING 2-METHYLALLYL CHLORIDE FROM 1,2-DICHLOROTERT-BUTANE
-
Paragraph 0026, (2021/11/26)
The present invention relates to a method for preparing 2-methylallyl chloride from 1,2-dichloro-tert-butane. The method is characterized in that 1,2-dichloro-tert-butane and a sodium hydroxide aqueous solution are used as raw materials; reactive rectification is performed in a combined rectifying tower to eliminate hydrogen chloride so as to obtain 2-methylallyl chloride. A plate type tower is provided at the lower part of the combined rectifying tower; a packing tower is provided at the upper part of the combined rectifying tower; an inner reflux condenser is provided at the top of the combined rectifying tower. The sodium hydroxide aqueous solution is added from a first plate of the plate type tower; and 1,2-dichloro-tert-butane is added from the middle part of the plate type tower. The method has the advantages that the raw material 1 and 1,2-dichloro-tert-butane is fully converted; the selectivity of the 2-methylallyl chloride is high.
Method for co-producing methyl chloropropene and 2-chloro-2-methylpropane by chlorination of isobutene
-
Paragraph 0025; 0026, (2020/01/12)
The invention discloses a method for co-producing methyl chloropropene and 2-chloro-2-methylpropane by chlorination of isobutene. According to the method, a chlorination reaction is carried out on chlorine or a mixture of chlorine and inert gas and excessive isobutene to obtain products, namely methyl chloropropene and 2-chloro-2-methylpropane. The method can reduce influence of micro-mixing on arapid chlorination reaction of isobutene, decarburization and coking do not occur easily, and 2-chloro-2-methylpropane can be co-produced while the yield of methyl chloropropene is improved.
Quaternary ammonium polychlorides as efficient reagents for chlorination of unsaturated compounds
Zelikman,Tyurin,Smirnov,Zyk
, p. 1541 - 1546 (2007/10/03)
Chlorination of unsaturated compounds by benzyltributylammonium polychlorides results in higher yields of addition products compared to those obtained with molecular chlorine.
