627-30-5Relevant articles and documents
Primary Alcohols via Nickel Pentacarboxycyclopentadienyl Diamide Catalyzed Hydrosilylation of Terminal Epoxides
Lambert, Tristan H.,Steiniger, Keri A.
supporting information, p. 8013 - 8017 (2021/10/25)
The efficient and regioselective hydrosilylation of epoxides co-catalyzed by a pentacarboxycyclopentadienyl (PCCP) diamide nickel complex and Lewis acid is reported. This method allows for the reductive opening of terminal, monosubstituted epoxides to form unbranched, primary alcohols. A range of substrates including both terminal and nonterminal epoxides are shown to work, and a mechanistic rationale is provided. This work represents the first use of a PCCP derivative as a ligand for transition-metal catalysis.
Method and system for producing 1, 3-propylene glycol by multi-step method
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Paragraph 0101; 0106-0107; 0110; 0115-0116; 0119; 0124-0125, (2021/01/28)
The invention discloses a method and a system for producing 1, 3-propylene glycol by a multi-step method. The method comprises the following steps: carrying out dehydration reaction on 1, 3-dichloropropanol and a dehydration catalyst to prepare 1, 3-dichloropropene; carrying out a first hydrolysis reaction on a first mixed reaction system containing the 1, 3-dichloropropene, a first hydrolysis agent and a first solvent to prepare 3-chloro-2-propene-1-alcohol; carrying out hydrogenation reaction on the 3-chloro-2-propene-1-alcohol and a hydrogenation catalyst to prepare 3-chloropropanol; and carrying out a second hydrolysis reaction on a second mixed reaction system containing the 3-chloropropanol, a second hydrolysis agent and a second solvent to prepare the 1, 3-propylene glycol. According to the method, 1, 3-dichloropropanol is used as a raw material, the important chemical raw material 1, 3-propylene glycol is prepared through a dehydration, hydrolysis, hydrogenation and hydrolysisfour-step method, and the method has the advantages of mild reaction conditions, low cost, environmental protection, economy and the like.
Chemical synthesis method of 3-chloro-1-propanol
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Paragraph 0030-0043, (2020/01/25)
The invention belongs to the technical field of chemical synthesis, and concretely relates to a chemical synthesis method of 3-chloro-1-propanol. 1,3-propylene glycol reacts with hydrochloric acid with benzenesulfonic acid as a catalyst to synthesize 3-chloro-1-propanol. The method comprises the following steps: 1,3-propylene glycol, a part of hydrochloric acid and benzenesulfonic acid are added into a reaction kettle and are reacted, the remaining hydrochloric acid is added into the reaction kettle, the obtained mixture is continuously reacted until the sampling analysis result shows that thesample is qualified, toluene is added, a heating reflux water-carrying reaction is carried out, the kettle is cooled to room temperature after the water-carrying reaction is completed, an oil phase in the kettle is neutralized to be neutral, the oil phase is pumped into a rectifying kettle, and is rectified until the sampling analysis result shows that the sample is qualified, and the finished product is separated out. The method which adopts the benzenesulfonic acid as the catalyst has the advantages of increase of the reaction efficiency, prevention of excessive chlorination, no generationof high-toxicity and high-pollution three wastes in the reaction, recyclability of byproducts, realization of the comprehensive yield of 95% or above, high conversion rate, high operability, low riskand low industrialization difficulty.
An Ultrasensitive Fluorescence Assay for the Detection of Halides and Enzymatic Dehalogenation
Aslan-üzel, A?k?n S.,Beier, Andy,Ková?, David,Cziegler, Clemens,Padhi, Santosh K.,Schuiten, Eva D.,D?rr, Mark,B?ttcher, Dominique,Hollmann, Frank,Rudroff, Florian,Mihovilovic, Marko D.,Bury?ka, Tomá?,Damborsky, Ji?í,Prokop, Zbyněk,Badenhorst, Christoffel P. S.,Bornscheuer, Uwe T.
, p. 2032 - 2039 (2020/02/11)
Halide assays are important for the study of enzymatic dehalogenation, a topic of great industrial and scientific importance. Here we describe the development of a very sensitive halide assay that can detect less than a picomole of bromide ions, making it very useful for quantifying enzymatic dehalogenation products. Halides are oxidised under mild conditions using the vanadium-dependent chloroperoxidase from Curvularia inaequalis, forming hypohalous acids that are detected using aminophenyl fluorescein. The assay is up to three orders of magnitude more sensitive than currently available alternatives, with detection limits of 20 nM for bromide and 1 μM for chloride and iodide. We demonstrate that the assay can be used to determine specific activities of dehalogenases and validate this by comparison to a well-established GC-MS method. This new assay will facilitate the identification and characterisation of novel dehalogenases and may also be of interest to those studying other halide-producing enzymes.
ADENOSINE A3 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
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, (2012/03/12)
Provided herein is a method of preventing, treating, or ameliorating one or more symptoms of an adenosine A3-mediated condition, disorder, or disease, with a compound of Formula I. Also provided herein is a method of preventing, treating, or ameliorating one or more symptoms of glaucoma or ocular hypertension. Further provided herein is a method of modulating the activity of an adenosine A3 receptor.
MANUFACTURE OF DICHLOROPROPANOL
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Page/Page column 18-19, (2009/03/07)
Manufacture of dichloropropanol Process for manufacturing dichloropropa nol wherein a glycerol-based product comprising at least one diol containi ng at least 3 carbon atoms other than 1,2- propanediol, is reacted with a chlorinati ng agent, and of products derived from dichloropropanol such as ep ichlorohydrin and epoxy resins. No figure.
Magnetically separable Pd catalyst for highly selective epoxide hydrogenolysis under mild conditions
Kwon, Min Serk,Park, In Soo,Jang, Jum Suk,Lee, Jae Sung,Park, Jaiwook
, p. 3417 - 3419 (2008/02/12)
A magnetically separable palladium catalyst was synthesized simply through a sol-gel process incorporating palladium nanoparticles and superparamagnetic iron oxide nanoparticles in aluminum oxyhydroxide matrix, which is highly active and selective for epoxide hydrogenolysis at room temperature under 1 atm H 2. The catalyst was recycled for 25 times without loss of the activity.
Oxidation of monohydric and dihydric alcohols with CCl4 catalyzed by molybdenum compounds
Khusnutdinov,Shchadneva,Burangulova,Muslimov,Dzhemilev
, p. 1615 - 1621 (2007/10/03)
Mo(CO)6 catalyzed oxidation of alcohols and diols with tetrachloromethane. Primary oxidation products in reaction of alcohols with CCl4 are alkyl hypochlorites, and final products depending on the structure of initial alcohol are aldehydes (as acetals), ketones, chloroketones, and esters.
Sodium borohydride-solid LiClO4: An effective reagent for reducing aldehydes and ketones in aprotic solvent
Halimjani, Azim Ziyaei,Saidi, Mohammad R.
, p. 2271 - 2276 (2007/10/03)
An efficient and simple method for the reduction of aldehydes, ketones and acid chlorides has been accomplished by using NaBH4-solid LiClO 4 in mild conditions at ambient temperature with complete chemoselectivity in reduction of α,β-unsaturated aldehydes and ketones. The reaction is fast with high yield and simple workup. Copyright Taylor & Francis, Inc.
A bimetallic system for the catalytic hydroxylation of remote primary C- H bonds in functionalized organics using dioxygen
Shen, Chengyu,Garcia-Zayas, Eduardo A.,Sen, Ayusman
, p. 4029 - 4031 (2007/10/03)
In a mixture of trifluoroacetic acid and water, the combination of metallic palladium and copper chloride catalyzes the hydroxylation of remote primary C-H bonds of a variety of acids, alcohols, and aliphatic halides, in the presence of carbon monoxide and dioxygen. Experiments suggest that the principal role of metallic palladium is to generate hydrogen peroxide in situ and that the species responsible for the remote hydroxylation of the substrate by hydrogen peroxide is copper chloride. The unusual preference for the catalytic hydroxylation of primary C-H bonds was also found in an experiment involving competition between ethane and either cumene or p- isopropylbenzoic acid: even though the solution concentration of ethane was significantly lower than the competing substrate, the vast majority of the oxidation product (ethanol) was derived from ethane. In the reactions studied, acetic acid and formic acid were formed through C-C cleavage steps. An examination of the site of C-C cleavage in propionic acid indicated that both C-C bonds were being broken.
