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Cas Database

79-21-0

79-21-0

Identification

  • Product Name:Peroxyacetic acid

  • CAS Number: 79-21-0

  • EINECS:201-186-8

  • Molecular Weight:76.052

  • Molecular Formula: C2H4O3

  • HS Code:29159000

  • Mol File:79-21-0.mol

Synonyms:Percidin 535;Perethanoic acid;Proxitane 12A;Proxitane 15;Proxitane 4002;Steridial P;Tsunami 100;Acetic peroxide;Agrosteril 110;Estosteril;LCAP;Osbon AC;Oxigreen010;Ozonit;Peraclean Ocean;

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Safety information and MSDS view more

  • Pictogram(s):OxidizingO,CorrosiveC,DangerousN

  • Hazard Codes:O,C,N

  • Signal Word:Danger

  • Hazard Statement:H226 Flammable liquid and vapourH242 Heating may cause a fire H302 Harmful if swallowed H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H332 Harmful if inhaled H400 Very toxic to aquatic life

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled Fresh air, rest. Half-upright position. Refer for medical attention. See Notes. In case of skin contact First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention . In case of eye contact First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. If swallowed Rinse mouth. Do NOT induce vomiting. Refer for medical attention . This is a very toxic compound. The probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 150 pound person. (EPA, 1998) Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. /Organic peroxides/

  • Fire-fighting measures: Suitable extinguishing media Use flooding quantities of water. Use water spray to keep fire-exposed containers cool. Fight fire from protected location or maximum possible distance. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. /Peracetic acid (less than 40%)/ Decomposes violently at 230F. When heated to decomposition, this compound emits acrid smoke and fumes. Runoff to sewer may create a fire or explosion hazard. Powerful oxidizer. Isolate from other stored material, particularly accelerators, oxidizers, and organic or flammable materials. Avoid shock and heat. Hazardous polymerization may not occur. (EPA, 1998) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Do NOT absorb in saw-dust or other combustible absorbents. Collect leaking and spilled liquid in covered plastic containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Cover with weak reducing agents such as hypo, bisulfites or ferrous salts. Bisulfites or ferrous salts need additional promoter of some 3M sulfuric acid for rapid reaction. Transfer the slurry (or sludge) into a large container of water and neutralize with soda ash. ...

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Fireproof. Provision to contain effluent from fire extinguishing. Separated from combustible substances and incompatible materials. See Chemical Dangers. Cool. Store only if stabilized. Store in an area without drain or sewer access.Store in a cool, dry, well-ventilated location. Separate from acids, alkalies, organic materials, heavy metals. Normally kept refrigerated outside or detached storage is preferred. /Peracetic acid (less than 40%)/

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Peracetic acid solution 32wt. % in dilute acetic acid
  • Packaging:500ml
  • Price:$ 177
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Peracetic acid solution 32wt. % in dilute acetic acid
  • Packaging:100ml
  • Price:$ 81
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Peracetic acid solution purum, ~39% in acetic acid (RT)
  • Packaging:100ml
  • Price:$ 78.2
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Peracetic acid solution 32wt. % in dilute acetic acid
  • Packaging:5ml
  • Price:$ 62.8
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:Peracetic Acid Quant? Test Strips
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Relevant articles and documentsAll total 144 Articles be found

Improvement of a process for preparing peracetic acid by the reaction of acetic acid with hydrogen peroxide in aqueous solutions, catalyzed by ion-exchange resins

Voronov,Sapunov,Makarov,Kulazhskaya,Kaleeva

, p. 421 - 431 (2016)

The effect of Amberlyst 15Dry cation-exchange resin on the reaction of peracetic acid formation from acetic acid and hydrogen peroxide in aqueous solution was studied. The pathways of available oxygen consumption were determined. The noncatalytic synthesis is accompanied by spontaneous decomposition of the peracid formed, which sharply decelerates on introducing Amberlyst 15Dry catalyst into the reaction mixture. Comparison of the kinetic relationships of the processes occurring in batch and flow-through reactors shows that in the latter case the process is characterized by diffusion hindrance. A kinetic model of the process with the parameters ensuring adequate mathematical description of the data obtained was suggested.

MgO/SnO2/WO3 as catalysts for synthesis of ε-caprolactone over oxidation of cyclohexanone with peracetic acid

Zhang, Guangxu,Ren, Xiaocong,Zhang, Hongbo,Peng, Yu,Gui, Shaoyong

, p. 59 - 63 (2014)

Different Mg/Sn/W mixed oxides prepared by precipitation were used as catalysts in the Baeyer-Villiger oxidation of cyclohexanone with a mixture of 50% hydrogen peroxide and acetic acid as oxidant. The Mg/Sn/W oxide obtained by precipitation from NH3·H2O was found to be the catalyst providing the highest yield of ε-caprolactone and initial catalytic activity among all samples.

Synthesis of chromium(III) complex with 1-hydroxy-2-pyridinone-6-carboxylic acid as insulin-mimetic agent and its spectroscopic and computational studies

Yasarawan, Nuttawisit,Thipyapong, Khajadpai,Sirichai, Somsak,Ruangpornvisuti, Vithaya

, p. 144 - 151 (2013)

The new complex of chromium(III) and 1-hydroxy-2-pyridinone-6-carboxylic acid was synthesized and its preparation routes were reported. Mass spectrometry and elemental analysis indicated the formation of chromium complex with the metal-to-ligand mole ratio of 1:3. Combination of spectroscopic measurement and spectral computations based on the density functional theory suggested that 1-hydroxy-2-pyridinone-6-carboxylic acid was a bidentate ligand using one oxygen atom at pyridinone carbonyl group and the other at N-oxide group as donor atoms upon chelation with chromium(III), forming the six-coordinate complex with five-membered chelate rings. Due to the enhanced stability of the chelate rings, such the pathway of chelation was theoretically predicted to be more favorable than the case where the carboxylate oxygen atom of ligand participated in the chelation. According to the preliminary tests, the chromium(III) complex with 1-hydroxy-2-pyridinone-6-carboxylic acid was found to be active in lowering plasma glucose levels in vivo.

Expanding the scope of gallium-catalyzed olefin epoxidation

Bronston, Fraser,Ting, Sharon,Zhang, Qiao,Goldsmith, Christian R.

, p. 268 - 272 (2016)

The broader use of Ga(III) complexes in the catalysis of olefin epoxidation was explored with a variety of studies. Two Ga(III) complexes with N-donor ligands were found to catalyze olefin epoxidation by peracetic acid in water. The stability of the catalyst more strongly influences the observed reactivity in water than in acetonitrile. Analysis of olefin epoxidation in buffered aqueous solutions indicates that either acidic or basic conditions are necessary for catalysis. The functional group tolerance was assessed using a variety of organic substrates. Alcohols, ketones, and alkylhalides survive the reaction conditions. Other common terminal oxidants were tested as possible replacements for peracetic acid but were not found to benefit from the presence of a Ga(III)-containing catalyst.

DECOMPOSITION OF HYDROGEN PEROXIDE IN ACETIC ACID, CATALYZED BY VANADIUM COMPLEXES

Makarov, A. P.,Polotnyuk, O. Ya.,Moiseev, I. I.

, (1983)

-

Keay,Hamilton

, p. 6578 (1976)

Safety advantages of on-site microprocesses

Ebrahimi, Fatemeh,Kolehmainen, Eero,Turunen, Ilkka

, p. 965 - 969 (2009)

Usually large-scale capacities are preferred in process industry because of the economics of scale. However, small capacities bring along several other advantages, which are emphasized especially in on-site production. By producing on-site, the transportation of dangerous chemicals can be avoided. Moreover, smaller on-site production processes also mean a step towards inherently safer technology. Microreactors represent a technology that efficiently utilizes safety advantages resulting from small scale. These safety advantages of microreactors in on-site production are studied in this contribution. Production of peracetic acid is used as a test case. This unstable and explosive chemical is used, e.g. in treatment of municipal wastewater and pulp bleaching. This study is based on comparison of a conventional batch process with the capacity of 170 kg/h and an on-site continuous microprocess producing 10 kg/h peracetic acid. Preliminary design of these processes was carried out. Four different methods were used to analyze the safety of the processes. It was found that the conventional methods for analysis of process safety might not be reliable and adequate for radically novel technology, such as microprocesses. This is understandable because the methods are partly based on experience, which is very limited in the connection of totally novel technology. 2009 American Chemical Society.

Efficient production of peracetic acid in aqueous solution with cephalosporin-deacetylating acetyl xylan esterase from Bacillus subtilis

Tao, Weiyi,Xu, Qing,Huang, He,Li, Shuang

, p. 2121 - 2127 (2015)

Peracetic acid (PAA) is widely used in sterilization, bleaching textile industry, environmental engineering, chemical synthesis, and biomimetic chemistry. A previous study reported that acetyl xylan esterase (AXE) of Bacillus subtilis CICC 20034 has high activity toward cephalosporin C and 7-aminocephalosporanic acid. In this study, we found that AXE also exhibited high perhydrolysis activity toward acetate esters and endowed itself with great industrial interest on enzyme-catalyzed preparation of PAA. Recombinant AXE of B. subtilis CICC 20034 could be efficiently produced in a low-cost autoinduction medium with an activity of 6.8 × 103 U/mL. The reaction conditions for the optimal synthesis of PAA were as follows: 0.30 mg/mL AXE crude enzyme, 300 mM glycerol triacetate, and 1 M hydrogen peroxide, pH 8.0, and 20 °C, which produced approximately 150 mM of PAA within 5 min. The AXE was then immobilized on an acrylate amino resin; the activity of the immobilized AXE was 383.7 U/g. In the presence of 1 g/mL of immobilized AXE resin, PAA titer of the initial reaction batch was approximately 142.5 mM, and about 95.5 mM of PAA could be produced after 10 cycles.

A new method for the preparation of peroxyacetic acid using solid superacid catalysts

Saha, Madhu Sudan,Nishiki, Yoshinori,Furuta, Tsuneto,Denggerile, Ao,Ohsaka, Takeo

, p. 5535 - 5537 (2003)

A new method for the preparation of peroxyacetic acid from acetic acid and hydrogen peroxide in the presence of solid superacids as a catalyst under mild conditions has been proposed. The preparation of peroxyacetic acid could be carried out in a batchwise operation as well as in a flow-system operation. Nafion-H was found to be active and very stable catalyst for the preparation of peroxyacetic acid and to be regenerated without the loss of catalytic activity.

Peracetic acid aqueous solution and method for producing the same

-

Paragraph 0042-0058, (2021/05/18)

A peracetic acid aqueous solution and a manufacturing method thereof are provided to be used in various fields including sterilizing washing agents for various medical devices, sterilizing washing agents for food production processes, disinfectants in papermaking processes, semiconductor etching agents, and the like. The peracetic acid solution of claim 1, wherein the peracetic acid solution has 25 weight percent of peracetic acid. The acetic acid of 0.5 ? 15 weight % acetic acid. Hydrogen peroxide 1 through 30 weight percent hydrogen peroxide. An organic acid comprising 1 and 15 weight % of organic acid. The chelating agent 1 according to 5 weight %. , And the remaining water. The chelating agent is selected from the group consisting of [[ [2,1- ethynyl nitrobis (methylene) tetrakis phosphonic acid, [bis amino] methyl phosphonic acid, 2 -phosphonobutane -1 , 2, 4- tricyclic acid, 2 -hydroxy phosphonoacetic acid and mixtures thereof.

Application of Continuous Flow in Tazobactam Synthesis

Sun, Tiemin,Wang, Jiasheng,Wu, Chengjun,Xin, Yunting,Zhou, Shuhao

, p. 1648 - 1657 (2021/07/19)

Tazobactam is a β-lactamase inhibitor. In this work, a combination of continuous flow and batch experiments for the synthesis of tazobactam has been developed. The first three steps and the preparation of the peroxyacetic acid are continuously carried out in the microreactors, which improves the procedure safety and efficiency. There is also a final step of the deprotection reaction in the microreactor, which can increase the yield and reduce the formation of impurities. Under optimized process conditions, the total yield of the target product reached 37.09% (30.93% in batch). The continuous flow method not only greatly reduces the reaction time but also significantly improves procedure safety and increases the yield.

Preparation method of 4,5-epoxytetrahydrophthalate glycidyl ester

-

Paragraph 0037-0052, (2022/01/10)

The present invention provides a method for preparing 4,5-epoxytetrahydrophthalate glycidyl ester. The present invention by taking acetic anhydride as raw material, adding 62.5% ~ 64.7% of hydrogen peroxide and a certain amount of acidic catalyst oxidation to generate peracetic acid, and then the tetrahydrophthalic acid glycidyl ester and the reaction of peracetic acid to obtain epoxy reaction, and then through a series of post-treatments to give 4,5-epoxytetrahydrophthalic acid glycidyl ester. The preparation method of the present invention is compared with the traditional process, which greatly reduces the concentration of hydrogen peroxide, thereby solving the problem that high concentration of hydrogen peroxide in the traditional process is easy to explode during storage, transportation and use, and also reduces the cost of raw materials. Compared with the prior art, the epoxy value of 4,5-epoxytetrahydrothphthalate glycidyl ester products prepared by the present invention is also higher.

Preparation method of 4AA

-

Paragraph 0016; 0018; 0019; 0021; 0022; 0024; 0025, (2021/07/28)

The invention discloses a preparation method of 4AA. The preparation method comprises the following steps: S1, preparing a first intermediate from benzamide and a formaldehyde aqueous solution; S2, preparing a second intermediate from the first intermediate, thionyl chloride, toluene and n-heptane; S3, preparing a third intermediate from the second intermediate, methyl acetoacetate, sodium methoxide, toluene, diluted hydrochloric acid and isopropanol; S4, preparing a fourth intermediate from the third intermediate, reductase, ethyl acetate, saturated sodium bicarbonate and saturated salt water; S5, preparing a fifth intermediate from the fourth intermediate, imidazole, TBSCL and methylbenzene; S6, preparing a sixth intermediate from the fifth intermediate, ethanolamine, methanol and n-heptane; S7, preparing a seventh intermediate by using the sixth intermediate, a Grignard reagent and n-heptane; and S8, preparing 4AA from the seventh intermediate, ruthenium trichloride, potassium acetate, ethyl acetate, acetic acid and a peracetic acid solution.

Efficient Assay for the Detection of Hydrogen Peroxide by Estimating Enzyme Promiscuous Activity in the Perhydrolysis Reaction

Wilk, Monika,Ostaszewski, Ryszard

, p. 1464 - 1469 (2021/02/01)

Hydrogen peroxide is an ideal oxidant in view of its availability, atom economy, or green aspects. Furthermore, it is produced by the cell mitochondria and plays a meaningful role in controlling physiological processes, but its unregulated production leads to the destruction of organs. Due to its diverse roles, a fast and selective method for hydrogen peroxide detection is the major limitation to preventing the negative effects caused by its excess. Therefore, we aimed to develop an efficient assay for the detection of H2O2. For this purpose, we combined the enzymatic method for the detection of hydrogen peroxide with the estimation of the promiscuity of various enzymes. We estimated the activity of an enzyme in the reaction of p-nitrophenyl esters with hydrogen peroxide resulting in the formation of peracid. To our knowledge, there is no example of a simple, multi-sensor demonstrating the promiscuous activity of an enzyme and detecting hydrogen peroxide in aqueous media.

Process route upstream and downstream products

Process route

triacetylglycerol
102-76-1

triacetylglycerol

sorbitan monooctanoate

sorbitan monooctanoate

peracetic acid
79-21-0

peracetic acid

peroxyoctanoic acid
33734-57-5

peroxyoctanoic acid

Conditions
Conditions Yield
With water; dihydrogen peroxide; sodium hydroxide; pH=>~12;
N,N,N',N'-tetraacetylethylenediamine
10543-57-4

N,N,N',N'-tetraacetylethylenediamine

peracetic acid
79-21-0

peracetic acid

N,Ν,Ν'-triacetylenediamine
137706-80-0

N,Ν,Ν'-triacetylenediamine

Conditions
Conditions Yield
With 1,2-ethanediylbistetraphosphonic acid; dihydrogen peroxide; at 25 ℃; Rate constant; pH 9.60 (carbonate buffer);
1,2-diacetoxypropane
623-84-7,134236-23-0

1,2-diacetoxypropane

peracetic acid
79-21-0

peracetic acid

propylene glycol
57-55-6,63625-56-9

propylene glycol

Conditions
Conditions Yield
With perhydrolase S54V; dihydrogen peroxide; at 20 ℃; for 0.333333h; Reagent/catalyst; Concentration; Kinetics; aq. phosphate buffer; Enzymatic reaction;
acetic acid
64-19-7,77671-22-8

acetic acid

peracetic acid
79-21-0

peracetic acid

formic acid
64-18-6

formic acid

methyl hydroperoxide
3031-73-0

methyl hydroperoxide

Conditions
Conditions Yield
With oxygen; zinc(II) oxide; In water; under 760 Torr; pH=7.8; Kinetics; UV-irradiation;
2-methylpropenal
78-85-3,25120-30-3

2-methylpropenal

peracetic acid
79-21-0

peracetic acid

methyl hydroperoxide
3031-73-0

methyl hydroperoxide

chloroacetone
78-95-5

chloroacetone

acetonyl hydroperoxide

acetonyl hydroperoxide

Conditions
Conditions Yield
With oxygen; chlorine; isopropyl alcohol; at 21.84 ℃; under 800 Torr; Photolysis;
dimethylglyoxal
431-03-8

dimethylglyoxal

methanol
67-56-1

methanol

peracetic acid
79-21-0

peracetic acid

formic acid
64-18-6

formic acid

acetic acid
64-19-7,77671-22-8

acetic acid

Conditions
Conditions Yield
With oxygen; In gas; at -10.1 ℃; for 0.0177778h; under 752 Torr; Product distribution; Mechanism; Irradiation; other times, temperatures and pressures;
acetaldehyde
75-07-0,9002-91-9

acetaldehyde

methanol
67-56-1

methanol

peracetic acid
79-21-0

peracetic acid

methyl hydroperoxide
3031-73-0

methyl hydroperoxide

acetic acid
64-19-7,77671-22-8

acetic acid

acetyl chloride
75-36-5

acetyl chloride

Conditions
Conditions Yield
With oxygen; nitrogen(II) oxide; chlorine; Nitrogen dioxide; at 24.9 ℃; under 700 Torr; Product distribution; Rate constant; Irradiation; various pressure; Cl-atom initiated oxidation of CH3CHO; pressure dependece of products and rate coefficients for the reaction of acetyl radicals; reaction CH3CHO with Cl2; relative rate coefficients of the reaction of Cl-atoms with CH3CHO and CH3OH;
acetone
67-64-1

acetone

peracetic acid
79-21-0

peracetic acid

carbon dioxide
124-38-9,18923-20-1

carbon dioxide

carbon monoxide
201230-82-2

carbon monoxide

Conditions
Conditions Yield
With nitrogen(II) oxide; at -48.15 ℃; Further Variations:; Reagents; Temperatures; Product distribution; Kinetics;
peracetic acid
79-21-0

peracetic acid

Conditions
Conditions Yield
With water; oxygen; sodium acetate; sodium sulfate; pH=4.4 - 11.4; Product distribution / selectivity; Electrochemical reaction;
butanone
78-93-3

butanone

peracetic acid
79-21-0

peracetic acid

3-hydroperoxy-butan-2-one
18428-20-1

3-hydroperoxy-butan-2-one

3-hydroxy-2-butanon
513-86-0,52217-02-4,51555-24-9

3-hydroxy-2-butanon

acetaldehyde
75-07-0,9002-91-9

acetaldehyde

acetic acid
64-19-7,77671-22-8

acetic acid

dimethylglyoxal
431-03-8

dimethylglyoxal

Conditions
Conditions Yield
With air; at 123 ℃; for 0.583333h; under 11025.9 Torr; Product distribution;

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