3973-08-8Relevant articles and documents
-
Cram et al.
, p. 1430,1435 (1963)
-
Method for preparing thiazole-4-formic acid
-
Paragraph 0021; 0028-0029; 0031; 0038-0039; 0041; 0048-0049, (2019/04/17)
The invention discloses a method for preparing thiazole-4-formic acid. By the aid of the method, the problems of relatively high prices of raw materials used in old processes for thiabendazole which is one of important traditional pesticide and bactericide varieties and low yield of the thiabendazole can be solved. The method includes steps of generating thiazolidine-4-formic acid from L-cysteinehydrochloride, formaldehyde and pyridine; carrying out reaction on the thiazolidine-4-formic acid, methyl alcohol and HCl gas to generate thiazolidine-4-methyl formate; carrying out reaction on the thiazolidine-4-methyl formate, acetonitrile and MnO2 to generate thiazole-4-methyl formate; hydrolyzing the thiazole-4-methyl formate under the effect of sodium hydroxide to obtain the thiazole-4-formicacid which is a product. The method has the advantages of simple process synthetic route, mild reaction condition, low cost, environmental protection, safety, excellent application prospect, good social benefit and high economic benefit.
Preparation method for thiazol-4-formic acid
-
Paragraph 0023; 0029; 0030; 0031; 0032; 0033; 0034-0041, (2018/03/24)
The invention discloses a preparation method for thiazol-4-formic acid. The method comprises the following steps: uniformly mixing ethyl bromopyruvate, thiourea and water, performing ring closure reaction, then adding concentrated hydrochloric acid for uniform mixing, adding dropwise an aqueous solution of sodium nitrite, performing stirring for 1.5 to 2.5h, performing filtering, and extracting a filter cake to obtain the thiazol-4-formic acid. The method is easy to operate, low in cost and suitable for industrial production, and the raw materials are cheap and are easily to obtain; water is used as a reaction solvent, and can be reutilized, so that the method is environment-friendly and pollution-free; the yield is high, and can reach 90 percent.