Welcome to LookChem.com Sign In|Join Free

Cas Database

77-78-1

77-78-1

Identification

  • Product Name:Sulfuricacid, dimethyl ester

  • CAS Number: 77-78-1

  • EINECS:201-058-1

  • Molecular Weight:126.133

  • Molecular Formula: C2H6O4S

  • HS Code:2920.90 Oral rat LD50: 205 mg/kg

  • Mol File:77-78-1.mol

Synonyms:Dimethyl sulphate;Methyl sulfate;NSC 56194;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):VeryT+

  • Hazard Codes:T+

  • Signal Word:Danger

  • Hazard Statement:H301 Toxic if swallowedH314 Causes severe skin burns and eye damage H317 May cause an allergic skin reaction H330 Fatal if inhaled H341 Suspected of causing genetic defects H350 May cause cancer

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention. In case of skin contact Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention. In case of eye contact Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention. If swallowed Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention. Acute: extremely toxic vapors and liquid -- a few whiffs or contact on skin could be fatal. Also acutely toxic if ingested. Delayed effects which are ultimately fatal may also occur. Lethal concentrations as low as 97 ppm/10 min have been reported in humans. DNA inhibition and damage to human somatic cells, and sister chromatid exchange in human fibroblast cells were observed. Delayed appearance of symptoms may permit unnoticed exposure to lethal quantities. (EPA, 1998) IN ALL CASES CONSULT A DOCTOR! INHALATION: Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. SKIN: Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention. EYES: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION: Rinse mouth. Give plenty of water to drink. Refer for medical attention immediately.

  • Fire-fighting measures: Suitable extinguishing media Water, foam, carbon dioxide, dry chemical ... . Material is normally stable even under fire exposure conditions and is not hazardously reactive with water. It is incompatible with strong oxidizers and strong ammonia solutions. (EPA, 1998) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. Spillage should only be dealt with by trained personnel wearing full protective clothing, a full-face mask, and positive-pressure breathing apparatus. Soda ash or 3% ammonia solution may be applied to liquid spills. Sprays of 3% ammonia solution may be used to "knock down" the vapor over spillages. After complete neutralization, spillages may be washed away... If dimethyl sulfate has entered a watercourse ... or contaminated soil or vegetation, advise the police and public authorities.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Cool. Dry. Well closed. Ventilation along the floor. Store in an area without drain or sewer access.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator, or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... . Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

  • Exposure controls/personal protection:Occupational Exposure limit valuesNIOSH considers dimethyl sulfate to be a potential occupational carcinogen.Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.1 ppm (0.5 mg/cu m), skin.Biological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:Dimethyl sulfate
  • Packaging:10g
  • Price:$ 130
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dimethyl sulfate for GC derivatization, ≥99.0% (GC)
  • Packaging:1ml
  • Price:$ 19.7
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dimethyl sulfate ≥99.8%
  • Packaging:18l-kl
  • Price:$ 1450
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dimethyl sulfate ≥99.5%
  • Packaging:18 L
  • Price:$ 1170
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dimethyl sulfate puriss. p.a., ≥99.0% (GC)
  • Packaging:1l
  • Price:$ 124
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dimethyl sulfate ≥99.8%
  • Packaging:1l
  • Price:$ 123
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dimethyl sulfate ≥99.8%
  • Packaging:4x100ml
  • Price:$ 117
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dimethyl sulfate for GC derivatization, ≥99.0% (GC)
  • Packaging:10x1ml
  • Price:$ 116
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dimethyl sulfate puriss. p.a., ≥99.0% (GC)
  • Packaging:500ml
  • Price:$ 89.3
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Dimethyl sulfate for GC derivatization, ≥99.0% (GC)
  • Packaging:10ml
  • Price:$ 86.1
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 19 Articles be found

-

Boulin,Simon

, p. 339 (1919)

-

Synthesis method of quaternary ammonium salt

-

Paragraph 0029; 0031; 0032, (2018/11/04)

The invention belongs to the technical field of preparation of chemicals and discloses a synthesis method of quaternary ammonium salt. The synthesis method comprises the following steps of: firstly reacting (CH3)2CO3 with H2SO4 to prepare (CH3)2SO4, then adding RN(CH3)2 to carry out quaternization reaction to prepare RN+(CH3)3O-SO2OCH3. The synthesis method disclosed by the invention has the advantages that generally, the one-pot reaction method is used and no solvent is used; by control of the feeding ratio, the reaction temperature and reaction substrate, the purity of the prepared quaternary ammonium salt is higher, and no residue of dimethyl sulfate and solvents is generated, so that the hazard of highly-toxic raw materials used in the traditional method to the environment and human isavoided; the synthesis method of the quaternary ammonium salt does not need reaction in the organic solvent, so that the production cost is reduced.

Understanding and control of dimethyl sulfate in a manufacturing process: Kinetic modeling of a fischer esterification catalyzed by H2SO 4

Guzowski Jr., John P.,Delaney, Edward J.,Humora, Michael J.,Irdam, Erwin,Kiesman, William F.,Kwok, Albert,Moran, Amy D.

body text, p. 232 - 239 (2012/06/18)

The formation and fate of monomethyl sulfate (MMS) and dimethyl sulfate (DMS) were studied by proton NMR for a sulfuric acid catalyzed esterification reaction in methanol. The kinetic rate constants for DMS and MMS were determined at 65 °C by fitting time-dependent experimental data to a model using DynoChem. In refluxing methanol, sulfuric acid was converted to monomethyl sulfate (MMS) in nearly quantitative yield within 45 min. Once formed, the MMS underwent a reversible esterification reaction to form DMS. Dimethylsulfate reacted with methanol to regenerate MMS and form dimethyl ether. A byproduct of the esterification reaction was water, which further consumed DMS through hydrolysis. On the basis of derived rate constants, in refluxing methanol, DMS would not be expected to exceed 4 ppm in the reaction mixture at equilibrium. In the presence of the carboxylic acid substrate, DMS was not detected in the reaction mixture. The reaction pathways of this system have been systematically investigated, and the results of this study will be presented.

A convergent approach to polycyclic aromatic hydrocarbons

Guignard, Raphael F.,Zard, Samir Z.

supporting information; experimental part, p. 12185 - 12187 (2011/12/15)

A new concise route to Polycyclic Aromatic Hydrocarbons (PAHs) through radical addition and cyclisation of xanthates is described. The Royal Society of Chemistry 2011.

Cu(II)-mediated methylthiolation of aryl C-H bonds with DMSO

Chu, Lingling,Yue, Xuyi,Qing, Feng-Ling

supporting information; scheme or table, p. 1644 - 1647 (2010/06/16)

(Figure Presented) An unprecedented Cu(II)-mediated methylthiolation of aryl C-H bonds under oxidative conditions that employs the widely available DMSO as the methylthiolation reagent is described. Various functional groups in the substrates were tolerat

Additives and products including oligoesters

-

, (2008/06/13)

The present invention relates to oligoesters and their use or the creation of additives. Oligoester containing additives and/or oligoesters themselves may be used for formulating pharmaceutical preparations, cosmetics or personal care products such as shampoos and conditioners. These oligoesters are particularly useful for the creation of multi-purpose additives that can impart conditioning, long substantivity and/or UV protection. Individual oligoesters and oligoester mixtures are described.

Process route upstream and downstream products

Process route

methyl p-toluene sulfonate
80-48-8

methyl p-toluene sulfonate

dimethyl disulfate
10506-59-9

dimethyl disulfate

p-toluenesulfonylanhydride
4124-41-8

p-toluenesulfonylanhydride

methyl 4-toluenepyrosulfonate
49829-22-3

methyl 4-toluenepyrosulfonate

C<sub>8</sub>H<sub>10</sub>O<sub>9</sub>S<sub>3</sub>
76443-13-5

C8H10O9S3

mixed anhydride of 4-toluenesulfonic acid and 4-toluenepyrosulfonic acid
76443-14-6

mixed anhydride of 4-toluenesulfonic acid and 4-toluenepyrosulfonic acid

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
Conditions Yield
With sulfur trioxide; at 100 ℃; Product distribution; other temperature, other molar ratio of reagents;
26.7 % Spectr.
4.5 % Spectr.
phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

trimethyl phosphite
512-56-1

trimethyl phosphite

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
Conditions Yield
With sulfur trioxide; In dichloromethane; at -50 ℃;
7%
93%
phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

trimethyl phosphite
512-56-1

trimethyl phosphite

O,O,O-trimethylthiophosphate
152-18-1

O,O,O-trimethylthiophosphate

dimethyl sulfate
77-78-1

dimethyl sulfate

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

Conditions
Conditions Yield
With sulfur trioxide; In dichloromethane; at -78 ℃; Product distribution; other trialkyl phosphite,trialkyl phosphine, trialkyl arsines, trialkoxyarsines, var. molar ratio and temperatures;
22%
4%
55%
19%
With sulfur trioxide; In dichloromethane; at -78 ℃;
48%
3%
9%
16%
ethyl methane sulfate
814-40-4

ethyl methane sulfate

diethyl sulfate
64-67-5

diethyl sulfate

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
Conditions Yield
methyl nitrite
624-91-9

methyl nitrite

ethyl chlorosulfate
625-01-4

ethyl chlorosulfate

diethyl sulfate
64-67-5

diethyl sulfate

ethyl methane sulfate
814-40-4

ethyl methane sulfate

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
Conditions Yield
dimethylsulfite
616-42-2

dimethylsulfite

methyl chlorosulfate
812-01-1

methyl chlorosulfate

methylene chloride
74-87-3

methylene chloride

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
Conditions Yield
at 120 - 190 ℃;
dimethylsulfite
616-42-2

dimethylsulfite

chlorine
7782-50-5

chlorine

methylene chloride
74-87-3

methylene chloride

methyl chlorosulfate
812-01-1

methyl chlorosulfate

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
Conditions Yield
at 120 - 140 ℃;
methanol
67-56-1

methanol

methyl chlorosulfate
812-01-1

methyl chlorosulfate

methylene chloride
74-87-3

methylene chloride

methyl bisulfate
75-93-4

methyl bisulfate

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
Conditions Yield
at -15 - -10 ℃; und folgenden Destillieren unter vermindertem Druck;
methanol
67-56-1

methanol

sulfur trioxide
7446-11-9

sulfur trioxide

methyl bisulfate
75-93-4

methyl bisulfate

sulfuric acid
7664-93-9

sulfuric acid

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
Conditions Yield
distn. in vac.;
distn. in vac. -5°C;
In tetrachloromethane; distn. in vac. -5°C;
distn. in vac. -5°C;
distn. in vac.;
In tetrachloromethane; distn. in vac. -5°C;
methanol
67-56-1

methanol

methyl bisulfate
75-93-4

methyl bisulfate

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
Conditions Yield
With sulfuric acid; at -60.05 ℃; Further Variations:; Temperatures; Reagents; Kinetics;

Global suppliers and manufacturers

Global( 35) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Hangzhou Dingyan Chem Co., Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-571-86465881,86-571-87157530,86-571-88025800
  • Emails:sales@dingyanchem.com
  • Main Products:95
  • Country:China (Mainland)
  • EAST CHEMSOURCES LIMITED
  • Business Type:Manufacturers
  • Contact Tel:86-532-81906761
  • Emails:josen@eastchem-cn.com
  • Main Products:97
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
  • Career Henan Chemical Co
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-371-86658258
  • Emails:purchase@coreychem.com
  • Main Products:137
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 77-78-1
Post Buying Request Now
close
Remarks: The blank with*must be completed