765-43-5Relevant articles and documents
(Di)triazolylidene manganese complexes in catalytic oxidation of alcohols to ketones and aldehydes
Pinto, Mara F.,Olivares, Marta,Vivancos, ángela,Guisado-Barrios, Gregorio,Albrecht, Martin,Royo, Beatriz
, p. 2421 - 2425 (2019)
Carbonyl manganese complexes with chelating or bridging mesoionic di(1,2,3-triazolylidene) ligands were efficiently synthesised and fully characterised, including the X-ray diffraction study of a bimetallic manganese(0) complex. This unprecedented bimetallic complex displayed high yield and selectivity in the catalytic oxidation of secondary alcohols and benzyl alcohol with tert-butyl hydroperoxide under mild conditions.
(±)-Camphor sulfonic acid assisted IBX based oxidation of 1° and 2° alcohols
Kumar, Kamlesh,Joshi, Penny,Rawat, Diwan S
, (2021/09/02)
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Safe and environment-friendly preparation method of cyclopropyl acetylene
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Paragraph 0037; 0043; 0057; 0063, (2020/08/22)
The invention relates to the field of medicine synthesis, and discloses a safe and environment-friendly preparation method of cyclopropylacetylene, which comprises the following steps: 1) performing chlorination reaction; 2) carrying out an ethynylation reaction; and 3) synthesizing cyclopropyl methyl ketone from the by-product E/Z-2, 5-dichloro-2-pentene. The process provided by the invention ishigh in chlorination yield; the chlorination reagent is triphosgene, the reaction condition is mild, and the safety is high. An organic solvent, inorganic base and a phase transfer catalyst system areadopted in the ethynylation reaction, and the yield is high; the high-flash-point organic solvent dilutes the reaction system, and the reaction is safe. E/Z-2-5-dichloro-2-pentene generated through the chlorination reaction is subjected to sulfuric acid dechlorination and cyclization and then converted into cyclopropyl methyl ketone, and application is achieved. Potassium chloride is treated as aby-product, and an organic solvent, water, organic alkali and a catalyst are used in chlorination reaction; an organic solvent and a phase transfer catalyst used in the ethynylation reaction can be recycled. The reaction is environment-friendly, only two potassium salt byproducts of potassium chloride and potassium sulfate are formed, and zero emission is basically realized.
Preparation method of 1-chloro-1-chloroacetyl cyclopropane
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Paragraph 0035; 0036, (2020/04/17)
The invention provides a preparation method of 1-chloro-1-chloroacetyl cyclopropane. The preparation method comprises the following steps: 1)reacting 1, 3-butadiene with diazomethane to generate vinylcyclopropane; 2)reacting the vinyl cyclopropane with an oxidation reagent to generate acetyl cyclopropane; and 3)reacting the acetyl cyclopropane with a chlorination reagent to generate the target product 1-chloro-1-chloroacetyl cyclopropane. The method can reduce the use of strong acids, strong bases and chlorination reagents in the preparation of the 1-chloro-1-chloroacetyl cyclopropane, thereby reducing the discharge of three wastes and lowering the safety risk, and can enhance the synthesis yield to adapt to industrial production.