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Cas Database

98-59-9

98-59-9

Identification

Synonyms:4-Methylbenzene-1-sulfonyl chloride;4-Methylbenzenesulfonylchloride;4-Methylphenylsulfonyl chloride;4-Toluenesulfonyl chloride;4-Toluensulfonyl chloride;4-Toluolsulfonyl chloride;4-Tosyl chloride;NSC175822;Toluenesulfonyl chloride;p-Methylbenzenesulfonylchloride;p-Methylphenylsulfonyl chloride;p-Toluenesulfochloride;p-Toluenesulfonic acid chloride;p-Toluenesulfonic chloride;p-Toluenesulphonylchloride;p-Tolylsulfonyl chloride;p-Tosyl chloride;p-Toluenesulfonylchloride (8CI);

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Safety information and MSDS view more

  • Pictogram(s):CorrosiveC

  • Hazard Codes:C,Xi

  • Signal Word:Danger

  • Hazard Statement:H314 Causes severe skin burns and eye damageH318 Causes serious eye damage

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:4-Toluenesulfonyl chloride
  • Packaging:250g
  • Price:$ 315
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:p-Toluenesulfonyl chloride
  • Packaging:50g
  • Price:$ 45
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:p-Toluenesulfonyl Chloride >99.0%(GC)
  • Packaging:25g
  • Price:$ 16
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:p-Toluenesulfonyl Chloride >99.0%(GC)
  • Packaging:500g
  • Price:$ 35
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:p-Toluenesulfonyl chloride 98%
  • Packaging:500 g
  • Price:$ 130
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:p-Toluenesulfonyl chloride 98%
  • Packaging:5 kg
  • Price:$ 428
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:p-Toluenesulfonyl chloride 98%
  • Packaging:1 kg
  • Price:$ 164
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-Toluenesulfonyl chloride
  • Packaging:8083265000
  • Price:$ 201
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-Toluenesulfonyl chloride for synthesis
  • Packaging:5 kg
  • Price:$ 192.4
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:p-Toluenesulfonyl chloride reagent grade, ≥98%
  • Packaging:3kg
  • Price:$ 180
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Relevant articles and documentsAll total 111 Articles be found

Facile synthesis of sulfonyl chlorides

Huang, Jianxing,Widlanski, Theodore S.

, p. 2657 - 2660 (1992)

A method for the synthesis of sulfonyl chlorides and bromides from the corresponding sulfonate salts is described. The method gives good yields of the acid halides under very mild conditions, and is compatible with both acid and base sensitive functionalities.

-

Ikutani

, p. 271 (1971)

-

Method for continuously synthesizing paratoluensulfonyl chloride by using microchannel reactor

-

Paragraph 0058-0100, (2021/08/21)

The invention discloses a method for continuously synthesizing paratoluensulfonyl chloride by using a micro-channel reactor. The method comprises the following steps: by using alkyl halide as a solvent, toluene as a raw material, chlorosulfonic acid as a chlorosulfonating agent and a material obtained by mixing toluene, chlorosulfonic acid, alkyl halide and a catalyst as a reaction starting material, feeding the reaction starting material into a microchannel reactor, carrying out chlorosulfonation reaction, and performing post-treatment on a reaction product flowing out of the microchannel reactor to obtain paratoluensulfonyl chloride. According to the invention, continuous production of p-toluenesulfonyl chloride can be realized, the production efficiency can be greatly improved, and the output of waste acid can be greatly reduced.

Method for continuously synthesizing P-toluenesulfonyl chloride

-

Paragraph 0089-0150, (2021/11/03)

The method comprises the following steps: toluene, sulfur trioxide, chlorosulfonic acid, an organic base and a solvent are mixed in first static mixers, and then pumped into first microreactors to react. The first Micro-reactor outlet discharged first reaction mixture flows into second static mixer and mixed with sulfur trioxide, chlorosulfonic acid, low carbon chain fatty acid and solvent pumped into second static mixers respectively, and the resulting mixed materials are pumped into second microreactors to react. The second The secondary reaction mixture discharged from the microreactor was cooled, crystallized and isolated to yield p-toluenesulfonyl chloride as a product. To the method, the production efficiency is greatly improved; due to the addition of the sulfone inhibitor, the problems that a large amount of sulfone substances and polysulfonate are easily generated by sulfonation of sulfur trioxide are effectively solved, and hydrogen chloride gas is prevented from being generated.

Modulating optical and electrochemical properties of perylene dyes by twisting aromatic π-system structures

Wang, Ying,Zhang, Qi,Gong, Junbo,Zhang, Xin

, (2021/03/04)

Three highly fluorescent perylene bisimide dyes were synthesized, where aromatic π-system structures are twisted to different degree by steric hindrance of two or four substitution groups at bay position. Light-emitting colours of these dye solutions can be modulated from green, yellow to red, and their fluorescence quantum yields increase up to approximate 100% with increasing the π-system twisting, which can be considered for new class of wavelength-tunable dye lasers. π-Twisted dyes are more sensitive to microenvironment changes. Thus, they are better fluorescence probe and sensory materials than planar dyes. Electrochemical cyclic voltammetry measurements revealed that these dyes are suitable for n-type optoelectrical devices and materials. These dye solids display near infra-red emission at 600–850 nm. Owing to strong π-π stacking interaction, planar dye solid loses its outstanding optical properties compared to its solution. In contrast, π-twisted dye solids retain their excellent optical properties including narrow emission bands and relatively high fluorescence quantum yields due to the suppression of π-π stacking interaction. Exceptional fluorescence polarization phenomena were observed for these π-twisted dye solids. These optical results revealed that π-twisted perylene bisimide dyes are more excellent optical materials than planar dyes.

Copper-Catalyzed N-Directed Distal C(sp3)-H Sulfonylation and Thiolation with Sulfinate Salts

Chen, Guang-Le,He, Shi-Hui,Cheng, Liang,Liu, Feng

supporting information, p. 8338 - 8342 (2021/10/25)

We herein report a selective and catalytic C(sp3)-H functionalization approach to access amines bearing organo-sulfonyl and organo-thiol groups. This reaction proceeds through a cascade process of N-radical formation, alkyl radical formation via 1,5-HAT, and C-S bond formation, thereby offering a series of functionalized amines. This method could enable primary, secondary, and tertiary C(sp3)-H sulfonylation and thiolation and also exhibits good functional group tolerance.

Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides

Chen, Rongxiang,Xu, Shaohong,Shen, Fumin,Xu, Canran,Wang, Kaikai,Wang, Zhanyong,Liu, Lantao

, (2021/09/20)

A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.

Process route upstream and downstream products

Process route

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Toluene-2-sulfonyl chloride
133-59-5

Toluene-2-sulfonyl chloride

Conditions
Conditions Yield
With chlorosulfonic acid; sodium chloride; at -0.16 ℃;
80%
20%
With chlorosulfonic acid; for 3h; Cooling with ice;
72.04%
With sulfuric acid; sodium chloride; Edukt 4: SO3;
3-methylphenylsulfonyl chloride
1899-93-0

3-methylphenylsulfonyl chloride

m-toluenesulfonic acid
617-97-0

m-toluenesulfonic acid

o-toluenesulfonic acid
88-20-0

o-toluenesulfonic acid

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Toluene-2-sulfonyl chloride
133-59-5

Toluene-2-sulfonyl chloride

Conditions
Conditions Yield
With chlorosulfonic acid; at 25 ℃; for 1.5h; Product distribution;
11.6 % Chromat.
3.2 % Chromat.
85.2 % Chromat.
16.1 % Chromat.
1.8 % Chromat.
82.1 % Chromat.
1-Tosyl-1-<2-(4-methoxyphenyl)ethyl>hydrazine
141666-87-7

1-Tosyl-1-<2-(4-methoxyphenyl)ethyl>hydrazine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

1-(2-Chloroethyl)-4-methoxybenzene
18217-00-0

1-(2-Chloroethyl)-4-methoxybenzene

Conditions
Conditions Yield
With N-chloro-succinimide; In tetrahydrofuran; for 16h; Ambient temperature; Irradiation;
82%
chlorosulfonic acid
7790-94-5

chlorosulfonic acid

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Toluene-2-sulfonyl chloride
133-59-5

Toluene-2-sulfonyl chloride

Conditions
Conditions Yield
at 0 ℃; und 15grad, 30grad und 60grad;
chlorosulfonic acid
7790-94-5

chlorosulfonic acid

aluminium trichloride
7446-70-0

aluminium trichloride

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Toluene-2-sulfonyl chloride
133-59-5

Toluene-2-sulfonyl chloride

Conditions
Conditions Yield
at 15 ℃;
chlorosulfonic acid
7790-94-5

chlorosulfonic acid

iron(III) chloride
7705-08-0

iron(III) chloride

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Toluene-2-sulfonyl chloride
133-59-5

Toluene-2-sulfonyl chloride

Conditions
Conditions Yield
at 15 ℃;
chlorosulfonic acid
7790-94-5

chlorosulfonic acid

(E)-3-Ureido-but-2-enoic acid ethyl ester
5435-44-9,22243-66-9

(E)-3-Ureido-but-2-enoic acid ethyl ester

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Toluene-2-sulfonyl chloride
133-59-5

Toluene-2-sulfonyl chloride

Conditions
Conditions Yield
at 15 ℃;
chlorosulfonic acid
7790-94-5

chlorosulfonic acid

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Toluene-2-sulfonyl chloride
133-59-5

Toluene-2-sulfonyl chloride

Conditions
Conditions Yield
at 15 ℃;
chlorosulfonic acid
7790-94-5

chlorosulfonic acid

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Toluene-2-sulfonyl chloride
133-59-5

Toluene-2-sulfonyl chloride

Conditions
Conditions Yield
at 65 ℃;
chlorosulfonic acid
7790-94-5

chlorosulfonic acid

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

Toluene-2-sulfonyl chloride
133-59-5

Toluene-2-sulfonyl chloride

Conditions
Conditions Yield
at 15 ℃;

Global suppliers and manufacturers

Global( 145) Suppliers
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  • Hangzhou Dingyan Chem Co., Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-571-86465881,86-571-87157530,86-571-88025800
  • Emails:sales@dingyanchem.com
  • Main Products:95
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  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
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  • Kono Chem Co.,Ltd
  • Business Type:Other
  • Contact Tel:86-29-86107037-8015
  • Emails:info@konochemical.com
  • Main Products:82
  • Country:China (Mainland)
  • EAST CHEMSOURCES LIMITED
  • Business Type:Manufacturers
  • Contact Tel:86-532-81906761
  • Emails:josen@eastchem-cn.com
  • Main Products:97
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:56
  • Country:China (Mainland)
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