503-30-0Relevant articles and documents
RADICAL CATIONS OF VARIOUS ETHENE, ETHINE AND CYCLIC ETHERS
Symons, Martyn C. R.,Wren, Brendon W.
, p. 2315 - 2318 (1983)
We have prepared the cations .(1+), .(1+) and .(1+) by the action of ionizing radiation on dilute solutions of neutral precursors in freon at 77 K, and used e.s.r. spectroscopy to study their structures.We have also studied the cations of oxirane, oxetane and methoxyethine for comparative purposes.
Photochemical reactions of trimethylene oxide radical cations in Freon matrices at 77 K
Mel'nikov, Mikhail Ya.,Belevskii, Vladilen N.,Kalugina, Anastasiya D.,Mel'nikova, Ol'ga L.,Pergushov, Vladimir I.,Tyurin, Daniil A.
, p. 305 - 306 (2008)
Radical cations of trimethylene oxide under photobleaching at 77 K could form either distonic radical cations ·CH2CH2CH=OH+/·CH2CH2O+=CH2 or oxetan-2-yl radicals depending on the Freon matrix used.
Study of the low temperature oxidation of propane
Cord, Maximilien,Husson, Benoit,Lizardo Huerta, Juan Carlos,Herbinet, Olivier,Glaude, Pierre-Alexandre,Fournet, Rene,Sirjean, Baptiste,Battin-Leclerc, Frederique,Ruiz-Lopez, Manuel,Wang, Zhandong,Xie, Mingfeng,Cheng, Zhanjun,Qi, Fei
, p. 12214 - 12228 (2013/02/25)
The low-temperature oxidation of propane was investigated using a jet-stirred reactor at atmospheric pressure and two methods of analysis: gas chromatography and synchrotron vacuum ultraviolet photoionization mass spectrometry (SVUV-PIMS) with direct sampling through a molecular jet. The second method allowed the identification of products, such as molecules with hydroperoxy functions, which are not stable enough to be detected by gas chromatography. Mole fractions of the reactants and reaction products were measured as a function of the temperature (530-730 K), with a particular attention to reaction products involved in the low temperature oxidation, such as cyclic ethers, aldehydes, alcohols, ketones, and hydroperoxides. A new model has been obtained from an automatically generated one, which was used as a starting point, with a large number of re-estimated thermochemical and kinetic data. The kinetic data of the most sensitive reactions, i.e., isomerizations of alkylperoxy radicals and the subsequent decompositions, have been calculated at the CBS-QB3 level of theory. The model allows a satisfactory prediction of the experimental data. A flow rate analysis has allowed highlighting the important reaction channels.
Spiro-cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha converting enzyme (TACE)
-
, (2008/06/13)
The present application describes novel spiro-cyclic β-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), and/or aggrecanase inhibitors.
Method for the preparation of 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs
-
, (2008/06/13)
1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.
Process for production of an oxetane
-
, (2008/06/13)
A process for production of an oxetane, which process comprises subjecting an alcohol having two or more hydroxyl groups to reaction with a carbamide at a molar ratio employing 1-2 moles of said carbamide on 1-2 moles of said alcohol. The alcohols preferably have at least one 1,3-diol grouping. The reaction is carried out in the presence of at least one catalyst promoting and/or initiating transcarbonylation and/or pyrolysis. A reaction mixture comprising an oxetane and optionally an orthocarbonate of said alcohol is yielded. The oxetane is suitable recovered from said reaction mixture by for instance distillation.
Coating composition comprising a bicyclo- or spiro-orthoester functional compound
-
, (2008/06/13)
The invention pertains to a coating composition comprising a first compound comprising at least one bicyclo- or spiro-orthoester group and a second compound comprising at least two hydroxyl-reactive groups. The invention also comprises a process for curing the present coating composition. More particularly, the latent hydroxyl groups of the bicyclo- or spiro-orthoester groups have to be deblocked and reacted with the hydroxyl-reactive groups of the second compound if the present coating composition is to be cured. Further, a process for making bicyclo-orthoester compounds from the corresponding oxetane compound is described, as are polymers comprising at least one bicyclo- or spiro-orthoester group.
Tricyclic and tetracyclic taxanes
-
, (2008/06/13)
The synthesis of taxol and other tricyclic and tetracyclic taxanes.
Hydrogen bonding Part 44 1Thermodynamics of complexation of 3,5-dichlorophenol with ketones and ethers in cyclohexane: The badger-Bauer relationship
Abraham, Michael H.,Prior, David V.,Schulz, Ronald A.,Morris, Jeffrey J.,Taylor, Peter J.
, p. 879 - 885 (2007/10/03)
Equilibrium constants for 1 : 1 hydrogen bond complexation between 3,5-dichioropheno' (DCP) and 17 ketones and 12 ethers in cyclohexane solution have been obtained by an FTIR method that takes into account both diiaerization of the acid and formation of 2 :1 complexes. Enthalpies of complexation for the same ketones and ethers have been determined by a calorimeiric method, leading to values of log K, AG, AH and AS0 for 1 :1 complexation in the 29 systems, as well as log K2 for the 2 :1 complexation between 2 mol of acid and 1 mol of base. For the ketone systems there is very little variation in the three thermodynamic parameters with alkyl substitution, but for the ethers there are systematic variations depending on the alkyl substituent or if the ethers are cyclic. Values of the OH stretching frequency in the DCP complexes with the ketones and ethers in cyclohexane have been obtained. The band shapes for the DCP-ketone complexes are very asymmetric, possibly due to the presence of stereoisomeric complexes, but the VOH band for DCP-ether complexes is symmetric and very suitable for the evaluation of any relationship between v()H and A/f. It is found that for the complexation of DCP with the 12 aliphatic ethers in cyclohexane, there is almost no connection between the calorimetrically determined AH° values and values of AvOH.
Total synthesis of taxol and analogues thereof
-
, (2008/06/13)
The present invention provides three basic routes for the total synthesis of taxol having the structure: STR1 The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.
