503-30-0 Usage
Chemical Properties
CLEAR COLOURLESS LIQUID
Uses
Trimethylene oxide useful for the synthesis of 3-substituted propanols by reaction with Grignards or organolithiums in the presence of CuBr.
Definition
ChEBI: A saturated organic heteromonocyclic parent that is a four-membered ring comprising of three carbon atoms and an oxygen atom.
General Description
Clear, colorless liquid with an agreeable aromatic odor.
Air & Water Reactions
Highly flammable. Water soluble.
Reactivity Profile
TRIMETHYLENE OXIDE reacts with Grignard reagents and organolithium compounds. TRIMETHYLENE OXIDE is also incompatible with oxidizing agents and strong acids. . An explosion occurred when propylene oxide was added to epoxy resin. Polymerization was catalyzed by amine accelerator in the resin [Bretherick 1995]. Propylene oxide and sodium hydroxide base-catalyzed the polymerization of the former, causing ignition and explosion of a drum of the crude product. [Combust Sci. Technol., 1983].
Fire Hazard
TRIMETHYLENE OXIDE is flammable.
Safety Profile
Moderately toxic by subcutaneous route. May be narcotic in high concentrations. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes
Purification Methods
Distil oxetane twice from sodium metal and then fractionate it through a small column at atmospheric pressure, b 47.0-47.2o. It can also be purified by preparative gas chromatography using a 2m silica gel column. Alternatively, add KOH pellets (50g for 100g of oxetane) and distil it through an efficient column or a column packed with 1/4in Berl Saddles with the main portion boiling at 45-50o being collected and redistilled over fused KOH. [Noller Org Synth Coll Vol III 835 1955, Dittmer et al. J Am Chem Soc 79 4431 1957, Beilstein 17 H 6, 17 I 3, 17 II 12, 17 III/IV 13, 17/1 V 11.]
Check Digit Verification of cas no
The CAS Registry Mumber 503-30-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 3 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 503-30:
(5*5)+(4*0)+(3*3)+(2*3)+(1*0)=40
40 % 10 = 0
So 503-30-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H6O/c1-2-4-3-1/h1-3H2
503-30-0Relevant articles and documents
RADICAL CATIONS OF VARIOUS ETHENE, ETHINE AND CYCLIC ETHERS
Symons, Martyn C. R.,Wren, Brendon W.
, p. 2315 - 2318 (1983)
We have prepared the cations .(1+), .(1+) and .(1+) by the action of ionizing radiation on dilute solutions of neutral precursors in freon at 77 K, and used e.s.r. spectroscopy to study their structures.We have also studied the cations of oxirane, oxetane and methoxyethine for comparative purposes.
-
Allen,Hibbert
, p. 1398,1399 (1934)
-
Method for the preparation of 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs
-
, (2008/06/13)
1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.
Spiro-cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha converting enzyme (TACE)
-
, (2008/06/13)
The present application describes novel spiro-cyclic β-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), and/or aggrecanase inhibitors.
