534-07-6

Basic information

• Product Name: 1,3-Dichloroacetone
• Synonyms: SYM-DICHLOROACETONE;,-Dichloroacetone;1,3-dichloro-2-propanon;1,3-dichloroacetona;1,3-dichloro-propan-2-one;1,3-dichloropropanone;2-Propanone, 1,3-dichloro-;2-Propanone,1,3-dichloro-
• CAS NO: 534-07-6
• Molecular Formula: C₃H₄Cl₂O
• Molecular Weight: 126.97
• EINECS: 208-585-6
• Product Categories: Miscellaneous;C3 to C6;Carbonyl Compounds;Ketones
• Mol File: 534-07-6.mol
• Article Data: 43

Chemical Properties

• Melting Point: 43 °C
• Boiling Point: 73 °C733.4 mm Hg(lit.)
• Flash Point: 193 °F
• Appearance: White or colorless/Crystals
• Density: 1.383 g/mL at 25 °C(lit.)
• Vapor Density: 4.38 (vs air)
• Vapor Pressure: <0.1 mm Hg ( 20 °C)
• Refractive Index: 1.4400
• Storage Temp.: Refrigerator (+4°C) + Poison room
• Solubility: alcohol: very soluble
• Water Solubility: 27.9 g/L (20 º C)
• Merck: 14,3052
• BRN: 605456
• CAS DataBase Reference: 1,3-Dichloroacetone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dichloroacetone(534-07-6)
• EPA Substance Registry System: 1,3-Dichloroacetone(534-07-6)

Safety Data

• Hazard Codes: T+,F
• Statements: 24-26/28-34-68-36/37/38-11
• Safety Statements: 26-36/37/39-45-28A-1-28-16
• RIDADR: UN 3286 3/PG 2
• WGK Germany: 3
• RTECS: UC1430000
• F: 19
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 534-07-6(Hazardous Substances Data)

Usage

Description

1,3-Dichloroacetone is a chemical substance with the molecular formula C3H4Cl2O. TLC has discovered that it is a metabolite of 1,3-dichloropropanol. The crystalline solid is denser than water and is not water-soluble.

Applications

1,3-Dichloroacetone is employed in the synthesis of citric acid. Additionally, it is used as an intermediate and a solvent in organic synthesis. Furthermore, 1,3-Dichloroacetone is utilized as an acceptor substrate in the cross-aldol reaction with donor substrates such as clyclohexanone, cyclopentanone, and acetone. 1,3-Dichloroacetone is also employed in the preparation of famotidine which is an active pharmaceutical ingredient.

Safety

When exposed or inhaled, 1,3-Dichloroacetone can result in damage or irritation to eyes, lungs, throat, kidney, and kidneys. It can also lead to fainting and headaches. The substance has been classified as extremely hazardous in America.

Chemical Properties

Different sources of media describe the Chemical Properties of 534-07-6 differently. You can refer to the following data:
1. White or colorless crystals
2. Bis(chhloromethyl)ketone is a crystalline solid.

Uses

1,3-Dichloroacetone was used as acceptor substrate in the cross-aldol reaction with donor substrates such as acetone, cyclopentanone and cyclohexanon

General Description

A crystalline solid. Denser than water and insoluble in water. Inhalation of dust or powder may cause adverse health reactions.

Air & Water Reactions

Insoluble in water.

Health Hazard

1,3-Dichloroacetone may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

When heated to decomposition, 1,3-Dichloroacetone emits highly toxic fumes of chlorides. 1,3-Dichloroacetone may burn but does not ignite readily. Container may explode in heat of fire.

Safety Profile

Poison by inhalation. Mutationdata reported. A systemic irritant by ingestion andinhalation routes. Dangerous; whenheated to decomposition it emits highly toxic fumes ofCl-.

Potential Exposure

Formerly extensively used in textiles (especially polyester fabrics) and still employed in polyurethane foams, textile backcoating and adhesives.

Shipping

UN2649 1,3-Dichloroacetone, Hazard class: 6.1; Labels: 6.1—Poisonous materials.

Purification Methods

Crystallise it from CCl4, CHCl3 or *benzene and/or distil under vacuum [Conant & Quayle Org Synth Coll Vol I 211 1941, Hall & Sirel J Am Chem Soc 74 836 1952]. It is dimorphic [Daasch & Kagarise J Am Chem Soc 77 6156 1955]. The oxime has m 130-131o, b 106o/25mm [Arzneimittel-Forsch 8 638 1958]. [Beilstein 1 IV 3219.]

Synthetic route

1,3-dibromoroacetone (816-39-7) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With potassium chloride In water at 20 - 60℃; for 0.333333h;	98%

bromo-3-chloro-propanone (53535-68-5) + 3-mercaptopropionitrile (1001-58-7) → 1-bromo-3-(2-cyanoethylthio)propanone + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
	A 94% B n/a

1,3-Dichloro-2-propanol (96-23-1) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With periodic acid In acetonitrile at 20℃; for 3h; Reagent/catalyst; Solvent; Temperature;	80%
With chromic acid
With chromium(III) oxide; sulfuric acid

Chloroiodomethane (593-71-5) + chloroacetic acid ethyl ester (105-39-5) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With methyllithium; lithium bromide In tetrahydrofuran; diethyl ether at -78℃; for 0.333333h;	60%
Yield given. Multistep reaction;

2,4-Dichlor-3-aminocrotonsaeurenitril (55549-51-4) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With hydrogenchloride for 72h;	58%

(Z)-1,3-Dichlor-2,4,4-trimorpholino-1,3-butadien-1-carbonitril (82313-45-9) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With hydrogenchloride at 60 - 70℃; for 10h; 2) Et2O, heating;	15%

diazomethane (186581-53-3, 908094-01-9) + phosgene (75-44-5) + diethyl ether (60-29-7) → 1,3-Dichloroacetone (534-07-6)

diazomethane (186581-53-3, 908094-01-9) + phosgene (75-44-5) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With diethyl ether

2,3-Dichloroprop-1-ene (78-88-6) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With hypochloric acid

bromo-3-chloro-propanone (53535-68-5) → 1,3-dibromoroacetone (816-39-7) + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
beim partielle Disproportionierung;

1,2-propanediene (463-49-0) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With hypochloric acid

di-isopropyl ether (108-20-3) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With chlorine at -20℃; im Licht;

1,3-diiodopropan-2-one (6305-40-4) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With silver(I) chloride

1-chloro-3-diazopropan-2-one (20485-53-4) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With hydrogenchloride
With hydrogenchloride In diethyl ether for 4h; Heating; Yield given;

acetone (67-64-1) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With chlorine; nickel dichloride

acetone (67-64-1) → 1,1-Dichloroacetone (513-88-2) + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With iron(III) chloride at 45℃; bei der Chlorierung;
With chlorine In tetrachloromethane Product distribution; 1.) below 40 deg C, 2.) room temperature, 0.5 h;	A 67 % Chromat. B 33 % Chromat.
With chlorine; acetic acid
With hydrogenchloride; chlorine
With antimonypentachloride; chlorine

epichlorohydrin (106-89-8) → 1,3-Dichloro-2-propanol (96-23-1) + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With disulfur dichloride beim Siedetemperatur;
With disulfur dichloride

α,α-Bis-Chlormethyl-α-hydroxy-essigsaeure-anhydrosulfit (2881-95-0) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
In chlorobenzene Heating;

1,2-propanediene (463-49-0) → dichloride of 1-chloro-2-propene-2-phosphonic acid (60367-21-7) + dichloride of 2-chloro-2-propene-1-phosphonic acid (40632-73-3) + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With oxygen; phosphorus trichloride Product distribution;

1,3-Dichloro-2-propanol (96-23-1) → 1,1,3-trichloroacetone (921-03-9) + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With ruthenium(IV) oxide; sodium chloride In water; ethyl acetate at 5℃; Product distribution; other organic solvents;	A 1 % Chromat. B 62 % Chromat.

1,3-dichloro-2,2-propanediol (82598-72-9) → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With dehydration at 25℃; Rate constant; Equilibrium constant; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.); isotope effects;
With water In acetonitrile Equilibrium constant; various temperatures (15-46 deg C), isotope effect;

Butane-1,4-diol (110-63-4) + acetone (67-64-1) → 1,1-Dichloroacetone (513-88-2) + 2-Chloromethyl-2-methyl-[1,3]dioxepane + 2,2-Bis(chloromethyl)-1,3-dioxacycloheptane (77416-10-5) + 2-dichloromethyl-2-methyl-1,3-dioxepane (146774-72-3) + chloroacetone (78-95-5) + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With chlorine Product distribution; 1.) 20-50 deg C, 2.) room temperature, 0.5 h;	A n/a B n/a C 28.3 % Chromat. D 13.8 % Chromat. E n/a F n/a

Butane-1,4-diol (110-63-4) + acetone (67-64-1) → 1,1-Dichloroacetone (513-88-2) + 2,2-Bis(chloromethyl)-1,3-dioxacycloheptane (77416-10-5) + 2-dichloromethyl-2-methyl-1,3-dioxepane (146774-72-3) + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With chlorine 1) 20-50 deg C; 2) room temp., 0.5 h; Further byproducts given. Yields of byproduct given;	A n/a B 28.3 % Chromat. C n/a D n/a

acetone (67-64-1) → 1,1-Dichloroacetone (513-88-2) + chloroacetone (78-95-5) + 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With hydrogenchloride at 23 - 25℃; electrochemical; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With hydrogenchloride at 23 - 25℃; electrochemical; Yield given. Yields of byproduct given;
With hydrogenchloride at 22 - 25℃; Product distribution; function of current and concentration;

epichlorohydrin (106-89-8) + disulfur dichloride → 1,3-Dichloro-2-propanol (96-23-1) + 1,3-Dichloroacetone (534-07-6)

α.γ-dichloro-acetoacetic acid ester → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With sulfuric acid

chloro-ethoxy-acetoacetic acid ester → 1,3-Dichloroacetone (534-07-6)

Conditions	Yield
With hydrogenchloride

symm.glycerol chlorohydrin → 1,3-Dichloroacetone (534-07-6)

hydrazinecarboxylic acid methyl ester (6294-89-9) + 1,3-Dichloroacetone (534-07-6) → methyl 2-[2-chloro-1-(chloromethyl)ethylidene]-1-hydrazinecarboxylate (87595-89-9)

Conditions	Yield
In diethyl ether for 15h; Ambient temperature;	100%
In methanol at 23℃; for 4h;	54%
for 3h; Ambient temperature; Yield given;
In methanol at 23℃; for 4h;

1,3-Dichloroacetone (534-07-6) + O-(1-E-cinnamyl)hydroxylamine hydrochloride → (E)-1,3-dichloroacetone O-(3-phenyl-2-propenyl)oxime (215599-97-6)

Conditions	Yield
In methanol at 40℃; for 2h;	100%

1,3-Dichloroacetone (534-07-6) + 1-morpholino-3-(morpholinomethylene)thiourea → bis-(2-morpholin-4-yl-thiazol-5-yl)-methanone (373602-92-7)

Conditions	Yield
Stage #1: 1,3-Dichloroacetone; 1-morpholino-3-(morpholinomethylene)thiourea In acetonitrile for 2h; Heating; Stage #2: With triethylamine In acetonitrile	100%

1,3-Dichloroacetone (534-07-6) → 1,3-diazido-propan-2-one (682353-67-9)

Conditions	Yield
With sodium azide In acetone at 20℃;	100%
With sodium azide In acetone at 20℃; for 12h;	96%
With sodium azide In acetone at 20℃; for 12h;	96%

2-N-piperidino-5-methyl-1,3-dithiolium-4-thiolate (85102-68-7) + 1,3-Dichloroacetone (534-07-6) → 1,3-bis(5-methyl-2-piperidinio-1,3-dithiol-4-ylsulfanyl)propan-2-one dichloride

Conditions	Yield
In acetone	100%

p-methoxybenzylmercaptan (6258-60-2) + 1,3-Dichloroacetone (534-07-6) → 1,3-bis-(4-methoxy-benzylsulfanyl)-propan-2-one

Conditions	Yield
With sodium methylate In ethanol for 1.5h; Heating;	100%

p-methoxythiobenzamide (2362-64-3) + 1,3-Dichloroacetone (534-07-6) → 4-methoxy-thiobenzimidic acid 3-chloro-2-oxo-propyl ester hydrochloride

Conditions	Yield
In acetone at 20℃; for 72h;	100%

4-cyanobenzothioamide (78950-30-8) + 1,3-Dichloroacetone (534-07-6) → C11H7ClN2S (873009-61-1)

Conditions	Yield
In ethanol for 3h; Heating / reflux;	100%

1,3-Dichloroacetone (534-07-6) + 4-(tert-butoxycarbonyl)piperazine-1-thiocarboxamide (196811-66-2) → 4-(4-chloromethylthiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester

Conditions	Yield
With sodium hydrogencarbonate In ethyl acetate; 1,2-dichloro-ethane	100%

naphthalene-2-carbothioamide (6967-89-1) + 1,3-Dichloroacetone (534-07-6) → 4-(chloromethyl)-2-(naphthalen-6-yl)thiazole (1094428-16-6)

Conditions	Yield
In ethanol Heating;	100%

6-fluoronaphthalene-2-carbothioamide (1424835-11-9) + 1,3-Dichloroacetone (534-07-6) → 4-(chloromethyl)-2-(2-fluoronaphthalen-6-yl)thiazole (1424835-28-8)

Conditions	Yield
In ethanol Heating;	100%

1,3-Dichloroacetone (534-07-6) + triethyl phosphite (122-52-1) → 3-chloro-2-<(diethoxyphosphoryl)oxy>-1-propene (81431-81-4)

Conditions	Yield
at 100℃;	99%
In dichloromethane for 166h; Ambient temperature;	98%
at 60 - 100℃; for 3h;	98.9%
at 50℃;

1,3-Dichloroacetone (534-07-6) → 1,3-dichloroacetone oxime (35433-52-4)

Conditions	Yield
With sulfuric acid; hydroxylamine hydrochloride In ethanol at 20℃; for 2h; Inert atmosphere;	99%
With hydroxylamine

1,2,3-Benzotriazole (95-14-7) + 1,3-Dichloroacetone (534-07-6) → 1,3-bis-(benzotriazol-1-yl)propan-2-one

Conditions	Yield
In benzene for 48h; Heating;	99%

triethylsilane (617-86-7) + 1,3-Dichloroacetone (534-07-6) → ((1,3-dichloropropan-2-yl)oxy)triethylsilane (7531-61-5)

Conditions	Yield
Stage #1: 1,3-Dichloroacetone With C8H10BiCl2N; C4H6AgN2(1+)*C24H12BCl8(1-) In dichloromethane-d2 at 25℃; Stage #2: triethylsilane In dichloromethane at 25℃;	99%
With C24H36AlN2O2(1+)*C24H12BCl8(1-) In benzene-d6 for 15h; Inert atmosphere; Schlenk technique; Glovebox;	98 %Spectr.

N,N'-ethylenethiourea (96-45-7) + 1,3-Dichloroacetone (534-07-6) → 3-(chloromethyl)-5,6-dihydroimidazo[2,1-b]thiazole hydrochloride

Conditions	Yield
In acetonitrile at 80℃; Inert atmosphere;	99%

1,3-Dichloroacetone (534-07-6) + benzenecarbothioamide (2227-79-4) → 2-phenyl-4-chloromethylthiazole (4771-31-7)

Conditions	Yield
In ethanol for 4h; Reflux;	98%
In ethanol for 2h; Reflux;	90%
Stage #1: 1,3-Dichloroacetone; benzenecarbothioamide In acetone Inert atmosphere; Reflux; Stage #2: With sulfuric acid for 0.5h; Inert atmosphere;	85%

1,3-Dichloroacetone (534-07-6) + triphenylphosphine (603-35-0) → (3-chloro-2-oxopropyl)triphenylphosphonium chloride (13605-65-7)

Conditions	Yield
In tetrahydrofuran for 24h; Reflux;	98%
In benzene at 20℃; for 6h;	98%
In tetrahydrofuran at 70℃; for 5h;	97%

O-benzylhydoxylamine hydrochloride (2687-43-6) + 1,3-Dichloroacetone (534-07-6) → 1,3-dichloro-2-propanone O-benzyloxime (188125-86-2)

Conditions	Yield
In ethanol Ambient temperature;	98%
In ethanol at 20℃; for 24h;	2.32 g

thioacetamide (62-55-5) + 1,3-Dichloroacetone (534-07-6) → 4-(chloromethyl)-2-methyl-1,3-thiazole (39238-07-8)

Conditions	Yield
In acetone	97%
at 20 - 50℃; for 20h;	93%
	92.9%

Potassium benzoate (582-25-2) + 1,3-Dichloroacetone (534-07-6) → 1,3-Dibenzoyl-1,3-dihydroxyacetone (38982-27-3)

Conditions	Yield
5,11,17,23,29,35-Hexa-p-tert-butyl-37,38,39,40,41,42-hexakis-(3,6,9-trioxadecyloxy)calix<6>arene In water; acetonitrile at 65℃; for 6h;	97%
With ethanol

2,2-Dimethyl-1,3-propanediol (126-30-7) + 1,3-Dichloroacetone (534-07-6) → 2,2-bis-(chloromethyl)-5,5-dimethyl-1,3-dioxane (133961-12-3)

Conditions	Yield
With toluene-4-sulfonic acid In benzene Heating;	97%
With toluene-4-sulfonic acid In benzene for 19h; Heating;	97%
With toluene-4-sulfonic acid In benzene for 18h; Heating;	97%

4-trifluoromethylbenzthioamide (72505-21-6) + 1,3-Dichloroacetone (534-07-6) → 4-chloromethyl-2-[4-(trifluoromethyl)phenyl]thiazole (135873-35-7)

Conditions	Yield
In toluene Reflux;	97%
In toluene at 80℃; for 4h;	62%
With thionyl chloride; sodium hydrogencarbonate 1.) 1,2-dichloroethane; Multistep reaction;
In 1,2-dichloro-ethane at 130 - 140℃; for 5h; Sealed tube;

1,3-Dichloroacetone (534-07-6) + triphenylphosphine (603-35-0) → 1-chloro-3-(triphenylphosphoranylidene)acetone (13605-66-8)

Conditions	Yield
Stage #1: 1,3-Dichloroacetone; triphenylphosphine In tetrahydrofuran for 4h; Heating; Stage #2: With sodium carbonate In methanol at 20℃; for 0.5h;	97%
Stage #1: 1,3-Dichloroacetone; triphenylphosphine In tetrahydrofuran for 24h; Heating; Stage #2: With sodium hydrogencarbonate In water Further stages.;	92%
In tetrahydrofuran for 24h; Heating;	91%

thiourea (17356-08-0) + 1,3-Dichloroacetone (534-07-6) → 4-(chloromethyl)thiazol-2-amine hydrochloride

Conditions	Yield
In acetone at 20 - 25℃; for 72h;	97%

1,3-Dichloroacetone (534-07-6) + trimethyl orthoformate (149-73-5) → 1,3-dichloroacetone dimethyl acetal (6626-57-9)

Conditions	Yield
With Amberlyst 15 In dichloromethane	96%

1,3-Dichloroacetone (534-07-6) + o-methoxycarbonyl-α-diazoacetophenone (18435-67-1) → 10,10-Bis-chloromethyl-1-methoxy-11,12-dioxa-tricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-8-one

Conditions	Yield
With copper acetylacetonate In benzene for 1h; Heating;	96%

ethyl 2-amino-2-thioxoacetate (16982-21-1) + 1,3-Dichloroacetone (534-07-6) → 4-(chloromethyl)thiazole-2-carboxylic acid-ethyl ester (100960-16-5)

Conditions	Yield
In toluene at 110℃; for 2h;	96%
In ethanol Heating / reflux;	37%
In ethanol for 15h; Heating;
In toluene for 2h; Inert atmosphere; Reflux;
In toluene Reflux;

phenyllithium (591-51-5) + 1,3-Dichloroacetone (534-07-6) → 1,3-dichloro-2-hydroxy-2-phenylpropane (87234-28-4)

Conditions	Yield
Stage #1: phenyllithium With cerium(III) chloride In tetrahydrofuran; diethyl ether; cyclohexane at -78℃; for 0.666667h; Stage #2: 1,3-Dichloroacetone In tetrahydrofuran; diethyl ether; cyclohexane at -78℃; for 0.166667h;	96%

Upstream product

• 53535-68-5 bromo-3-chloro-propanone 
• 6305-40-4 1,3-diiodopropan-2-one 
• 20485-53-4 1-chloro-3-diazopropan-2-one 
• 67-64-1 acetone 
• 593-71-5 Chloroiodomethane 
• 105-39-5 chloroacetic acid ethyl ester 
• 110-63-4 Butane-1,4-diol 
• 78-88-6 2,3-Dichloroprop-1-ene 
• 96-23-1 1,3-Dichloro-2-propanol 
• 106865-88-7 ClCH₂Co(COOCH₃)(CO)3^(1-) 
• 106865-88-7 Na⁽¹⁺⁾*ClCH₂Co(COOCH₃)(CO)3^(1-)=Na(ClCH₂Co(COOCH₃)(CO)3) 
• 463-49-0 1,2-propanediene 
• 107-05-1 3-chloroprop-1-ene 
• 6626-57-9 1,3-dichloroacetone dimethyl acetal 

Downstream Products

• 39238-07-8 4-(chloromethyl)-2-methyl-1,3-thiazole 
• 102612-70-4 1,3-dichloro-2,2-bis-(4-methoxy-phenyl)-propane 
• 861600-81-9 2,2'-(2-oxo-propanediyldimercapto)-di-benzoic acid 
• 7250-84-2 2-Amino-4-chloromethyl-1,3-thiazole 
• 20167-22-0 S-<(2-amino-4-thiazolyl)methyl>isothiourea dihydrochloride 
• 20166-91-0 S-(2-amino-thiazol-4-ylmethyl)-isothiourea 
• 118000-39-8 2-(chloromethyl)-5-methylimidazo[1,2-a]pyridine 
• 22381-59-5 1,1-Bis-<2-hydroxy-4,4-dimethyl-6-oxo-cyclohexenyl>-2-oxo-propan 
• 57892-71-4 2-chloromethylimidazo<1,2-a>pyrimidine 
• 87234-28-4 1,3-dichloro-2-hydroxy-2-phenylpropane 
• 180331-46-8 1,1-dichloromethyl-3-phenylprop-3-en-1-ol 
• 180331-45-7 2-benzyl-1,3-dichloropropan-2-ol 
• 597-32-0 1,3-dichloro-2-methyl-propan-2-ol 
• 59608-97-8 4-(chloromethyl)thiazol-2-amine hydrochloride 

Relevant articles and documents

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3-chloro-2-chloromethyl propylene, preparation method and application thereof

The invention relates to 3-chloro-2-chloromethyl propene, a preparation method and application thereof. The preparation method comprises the step that 1, 3-dichloroacetone is subjected to a carbonization reaction under the action of a catalyst to obtain 3-chloro-2-chloromethyl propene. According to the invention, 1, 3-dichloroacetone serves as a raw material and is subjected to a carbonization reaction under the action of a catalyst to obtain a product 3-chloro-2-chloromethyl propene in one step, wherein the raw materials are easy to obtain, the steps are simple, a large amount of wastewater is not generated in the preparation process, the method is environment-friendly, the yield of the final product is high and can reach 51-65%, and the 3-chloro-2-chloromethyl propylene can be applied to the synthesis of bridged ring compounds.

Expeditious Syntheses to Pharmochemicals 1,3-Dihydroxyacetone, 1,3-Dichloro-, 1,3-Dibromo- And 1,3-Diiodoacetone from Glycerol 1,3-Dichlorohydrin Using Homogenous and Heterogenous Medium

New efficient and reproductive routes to production of 1,3-dihydroxyacetone (1), 1,3-dichloroacetone (6), 1,3-dibromoacetone (7) and 1,3-diiodoacetone (8) from glycerol 1,3-dichlorohydrin (3) were developed. The synthesis of 1 was processed in three steps from glycerol 2 (1,3-selective chlorination of 2 to 3, oxidation of 3 to 6 and subsequent di-hydroxylation) in 51% overall yield. On the other hand, 7 and 8 were produced from 3, via a trans-bromination and trans-iodination, respectively, followed by oxidation and hydroxylation steps, in 38-52% overall yield. It was used homogeneous media with different reagents (HCl/AcOH, pyridinium chlorochromate (PCC), PCC-HIO4) and heterogeneous media with reagents supported on polymer resins such as Amberlyst A26-HCrO4– form, PV-PCC (polyvinyl-pyridinium chlorochromate) and Amberlyst A26-OH– form or reagents supported on alumina such as KI/Al2O3, KBr/Al2O3, in solvent free conditions.

Preparation method of 1,3-dihydroxyacetone

The invention relates to the technical field of organic synthesis, and discloses a preparation method of 1, 3-dihydroxyacetone. The preparation method of 1,3-dihydroxyacetone comprises the following steps: (1) carrying out contact reaction between glycerol and halogenated reagents in presence of a catalyst to prepare 1,3-dichloro-2-propanol; (2) carrying out oxidative dehydrogenation reaction on the 1,3-dichloro-2-propanol to obtain an intermediate product 1,3-dichloro-2 acetone; (3) contacting the 1,3-dichloro-2 acetone with alkali substances in a water-containing medium for hydrolysis reaction to obtain the 1,3-dihydroxyacetone, wherein a hydrolysis reaction temperature is 25 to 60 DEG C. According to the preparation method of the 1,3-dihydroxyacetone, the conversion rate of the glycerol and the yield of the 1,3-dihydroxyacetone are higher; by taking zirconium oxide as the catalyst, the preparation method disclosed by the invention is high-efficient, is low in cost and has industrial application prospect.