108-56-5Relevant articles and documents
Bigg
, p. 571,573,574 (1976)
Impact of Stereo- And Regiochemistry on Energetic Materials
Barton, Lisa M.,Edwards, Jacob T.,Johnson, Eric C.,Bukowski, Eric J.,Sausa, Rosario C.,Byrd, Edward F. C.,Orlicki, Joshua A.,Sabatini, Jesse J.,Baran, Phil S.
supporting information, p. 12531 - 12535 (2019/08/26)
The synthesis, physical properties, and calculated performances of six stereo- and regioisomeric cyclobutane nitric ester materials are described. While the calculated performances of these isomers, as expected, were similar, their physical properties were found to be extremely different. By alteration of the stereo- and regiochemistry, complete tunability in the form of low- or high-melting solids, stand-alone melt-castable explosives, melt-castable explosive eutectic compounds, and liquid propellant materials was obtained. This demonstrates that theoretical calculations should not be the main factor in driving the design of new materials and that stereo- and regiochemistry matter in the design of compounds of potential relevance to energetic formulators.
Preparation method of 2-(4-fluorophenyl)pyrimidine derivative
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Paragraph 0020; 0021; 0022, (2018/03/26)
The invention discloses a preparation method of a 2-(4-fluorophenyl)pyrimidine derivative: 6-chloro-2-(4-fluorophenyl)pyrimidine-4-carboxylate. Diethyl oxalate is used as a starting raw material, andcondensation, cyclization, chlorination and esterification are performed for obtaining a target product. The compound is an important medical intermediate.
Preparation method of 2-nitropyrimidine derivative
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Paragraph 0021; 0022, (2017/08/29)
The invention discloses a preparation method of 2-nitropyrimidine derivative which is methyl 6-chloro-2-nitropyrimidine-4-carboxylate. The method comprises the following steps: taking diethyl oxalate as a starting raw material, and carrying out condensation, cyclization, chlorination and esterification to obtain a target product. The compound is used as an important medical intermediate.