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Cas Database

500-22-1

500-22-1

Identification

  • Product Name:3-Pyridinecarboxaldehyde

  • CAS Number: 500-22-1

  • EINECS:207-900-4

  • Molecular Weight:107.112

  • Molecular Formula: C6H5NO

  • HS Code:29333999

  • Mol File:500-22-1.mol

Synonyms:Nicotinaldehyde(8CI);3-Formylpyridine;3-Pyridinaldehyde;3-Pyridinealdehyde;3-Pyridylaldehyde;NSC 8952;Nicotinealdehyde;Nicotinic aldehyde;Pyridine-3-carbaldehyde;Rowalind;m-Formylpyridine;b-Formylpyridine;b-Pyridinecarbonaldehyde;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi,CorrosiveC,HarmfulXn

  • Hazard Codes:Xi,C,Xn

  • Signal Word:Danger

  • Hazard Statement:H317 May cause an allergic skin reactionH334 May cause allergy or asthma symptoms or breathing difficulties if inhaled H341 Suspected of causing genetic defects

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TRC
  • Product Description:3-Pyridinecarboxaldehyde
  • Packaging:50g
  • Price:$ 75
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  • Manufacture/Brand:TCI Chemical
  • Product Description:3-Pyridinecarboxaldehyde >98.0%(GC)
  • Packaging:500mL
  • Price:$ 576
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  • Manufacture/Brand:TCI Chemical
  • Product Description:3-Pyridinecarboxaldehyde >98.0%(GC)
  • Packaging:25mL
  • Price:$ 68
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  • Manufacture/Brand:TCI Chemical
  • Product Description:3-Pyridinecarboxaldehyde >98.0%(GC)
  • Packaging:100mL
  • Price:$ 199
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Nicotinaldehyde 98%
  • Packaging:100 g
  • Price:$ 176
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:3-Pyridinecarboxaldehyde 98%
  • Packaging:25g
  • Price:$ 33.5
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:3-Pyridinecarbaldehyde forsynthesis
  • Packaging:50 mL
  • Price:$ 72.52
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:3-Pyridinecarbaldehyde for synthesis. CAS 500-22-1, chemical formula 3-(CHO)C H N., for synthesis
  • Packaging:8074680250
  • Price:$ 337
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:3-Pyridinecarbaldehyde forsynthesis
  • Packaging:250 mL
  • Price:$ 322.82
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:3-Pyridinecarbaldehyde for synthesis. CAS 500-22-1, chemical formula 3-(CHO)C H N., for synthesis
  • Packaging:8074680050
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Relevant articles and documentsAll total 126 Articles be found

-

Suvorov et al.

, (1969)

-

V2O5/TiO2 Catalysts for the Vapor-Phase Oxidation of β-Picoline: Influence of the TiO2-Carrier

Heinz,Hoelderich,Krill,Boeck,Huthmacher

, p. 1 - 10 (2000)

The heterogeneously catalyzed vapor-phase oxidation of β-picoline to nicotinic acid over a series of V2O5/TiO2 was investigated. Characterizations of the catalysts were carried out using X-ray diffraction, temperature-programmed desorption, and N2-adsorption. It was found that the use of an anatase type of TiO2-carrier with a higher BET surface area enhances the activity of the V/Ti-oxide catalyst enormously. TiO2-materials with different BET surface areas (between 10 and 270 m2/g) were used. Since these different materials originate from different processes, namely, the chloride and the sulfate process, the influence of the sulfate content was investigated. Additionally, the use of different TiO2 crystalline structures (anatase vs rutile) was evaluated, and a sulfate-free TiO2-material was modified with sulfate and cerium oxide during vanadia impregnation. The results of these experiments verified that the sulfate content itself did not have a strong influence on the catalyst activity. XRD-characterization of the catalysts demonstrated that only the TiO2 and the V2O5 phase could be detected. This corresponds with other investigations in the literature and strengthens the assumption that there is a synergetic effect of a V2O5 layer supported by TiO2 as a catalyst carrier. Therefore the increase of the interface between these two crystalline phases is the determining factor to improve the catalyst's activity.

Selective photocatalytic oxidation of 3-pyridinemethanol on platinized acid/base modified TiO2

?etinkaya, S?d?ka,Augugliaro, Vincenzo,Garlisi, Corrado,Lewin, Erik,Palmisano, Giovanni,Sá, Jacinto,Yurdakal, Sedat

, p. 4549 - 4559 (2021)

TiO2catalysts, modified with acidic or alkaline solutions and then platinized, were used for the partial photocatalytic oxidation of 3-pyridinemethanol to 3-pyridinemethanal and vitamin B3under environmentally friendly conditions. The reaction took place in water under UVA light and air oxygen. Catalysts were characterized by TEM, photoluminescence, DRIFT-IR, Raman, DRS, XPS, and photocurrent measurements. The photocatalytic activity results show that Pt loading of untreated samples leads to a significant activity improvement (hence product yield) as much as acid and alkaline treatments do. Moreover, the alkaline treated TiO2samples exhibit a further increase in activity after loading with Pt. Pt acts as an electron scavenger promoting electron transfer from the TiO2conduction band, consequently boosting the photogenerated pair numbers available for the reactive process. Photocurrent measurements show that the TiO2photocatalysts' active sites increase significantly after platinization and alkaline/acid treatment. The treated and/or Pt loaded catalysts showed good thermal stability (at least up to 400 °C).

Degradation of quinoline by wet oxidation - Kinetic aspects and reaction mechanisms

Thomsen, Anne Belinda

, p. 136 - 146 (1998)

The high temperature, high pressure wet oxidation reaction of quinoline has been studied as a function of initial concentration, pH and temperature. At neutral to acidic pH, it is effective in the oxidation of quinoline at 240°C and above, whereas under alkaline conditions the reaction is markedly slowed down. The results indicate that the reaction is an auto-catalysed, free radical chain reaction transforming 99% of quinoline to other substances. Of the quinoline, 30-50% was oxidised to CO2 and H2O depending on the initial concentration. Wet oxidation of deuterium-labelled quinoline was used as a method for verifying and quantifying the reaction products. Fifteen reaction products were identified and quantitatively determined, accounting for 70% of the carbon present after treatment. Nicotinic acid was a main product, accounting for up to 35% of the parent substance. The formation of succinic acid is suggested to be a result of a coupling reaction of the acetic acid radical. A reaction mechanism is suggested for the degradation of quinoline; it involves hydroxyl radicals and the possible interaction with autoclave walls is discussed. The high temperature, high pressure wet oxidation reaction of quinoline has been studied as a function of initial concentration, pH and temperature. At neutral to acidic pH, it is effective in the oxidation of quinoline at 240°C and above, whereas under alkaline conditions the reaction is markedly slowed down. The results indicate that the reaction is an auto-catalysed, free radical chain reaction transforming 99% of quinoline to other substances. Of the quinoline, 30-50% was oxidised to CO2 and H2O depending on the initial concentration. Wet oxidation of deuterium-labelled quinoline was used as a method for verifying and quantifying the reaction products. Fifteen reaction products were identified and quantitatively determined, accounting for 70% of the carbon present after treatment. Nicotinic acid was a main product, accounting for up to 35% of the parent substance. The formation of succinic acid is suggested to be a result of a coupling reaction of the acetic acid radical. A reaction mechanism is suggested for the degradation of quinoline; it involves hydroxyl radicals and the possible interaction with autoclave walls is discussed.

Mild reductive deoximation with TiCl4/NaI reagent system

Balicki,Kaczmarek

, p. 1777 - 1782 (1991)

The application of the TiCl4/NaI reagent system in the reductive cleavage of oximes under mild conditions is reported.

3-picoline oxidation over monoclinic orthovanadate Cr0.5Al0.5VO4 catalysts

Zhaoxia, Song,Kadowaki, Eriko,Shishido, Tetsuya,Wang, Ye,Takehira, Katsuomi

, p. 754 - 755 (2001)

Monoclinic orthovanadate CrVO4-I was found to be active for the vapor phase oxidation of 3-picoline to nicotinic acid and was further activated by the solid solution formation with Al at the Cr site.

-

Schoenberg,A.,Heck,R.F.

, p. 7761 - 7764 (1974)

-

TiO2/graphene-like photocatalysts for selective oxidation of 3-pyridine-methanol to vitamin B3 under UV/solar simulated radiation in aqueous solution at room conditions: The effect of morphology on catalyst performances

Alfè, Michela,Spasiano, Danilo,Gargiulo, Valentina,Vitiello, Giuseppe,Capua, Roberto Di,Marotta, Raffaele

, p. 91 - 99 (2014)

Graphene-like layers, synthesized through a two-step oxidation/reduction wet treatment of a high surface carbon black, have been used to prepare composites with TiO2 nanoparticles by liquid phase deposition, followed by calcination at 200 °C. The photocatalytic activity of the TiO2/graphene-like composites has been tested for the selective conversion of 3-pyridine methanol to 3-pyridine carboxyaldehyde and nicotinic acid (vitamin B3), under de-aerated and UV/solar simulated conditions, in the presence of cupricions. Two different composite morphologies have been explored and a dependence of the photocatalytic activity has been assessed. An enhanced photocatalytic activity, with respect to the neat TiO2, has been observed and attributed to the broader variety of stable free-radical species generated, at a given photo-catalyst morphology, within the delocalized π-electron systems.

Micellar effects on kinetics and mechanism of Vilsmeier–Haack formylation and acetylation with Pyridines

Alyami, Bandar A.,Iqubal, S. M. Shakeel,Khan, Aejaz Abdullatif,Mohammed, Tasneem

, (2022/01/19)

An efficient preparation of Vilsmeier–Haack formylated and acetylated derivatives with pyridine and substituted pyridines has been developed by employing micelles as catalyst. Their kinetic study reveals a phenomenal rate enhancement in anionic SDS, cationic CTAB, and nonionic TX-100 micellar media. The Vilsmeier–Haack reaction follows second order kinetics. Piszkiewicz’s co-operativity model was used to interpret the results in micellar media. The observed activation parameters ΔH and ΔS values were calculated from Eyring’s plots. The main features of this study were easy process, mild reaction conditions and readily available reagents. Graphical abstract: [Figure not available: see fulltext.].

Photoredox-Catalyzed Simultaneous Olefin Hydrogenation and Alcohol Oxidation over Crystalline Porous Polymeric Carbon Nitride

Qiu, Chuntian,Sun, Yangyang,Xu, Yangsen,Zhang, Bing,Zhang, Xu,Yu, Lei,Su, Chenliang

, p. 3344 - 3350 (2021/07/26)

Booming of photocatalytic water splitting technology (PWST) opens a new avenue for the sustainable synthesis of high-value-added hydrogenated and oxidized fine chemicals, in which the design of efficient semiconductors for the in-situ and synergistic utilization of photogenerated redox centers are key roles. Herein, a porous polymeric carbon nitride (PPCN) with a crystalline backbone was constructed for visible light-induced photocatalytic hydrogen generation by photoexcited electrons, followed by in-situ utilization for olefin hydrogenation. Simultaneously, various alcohols were selectively transformed to valuable aldehydes or ketones by photoexcited holes. The porosity of PPCN provided it with a large surface area and a short transfer path for photogenerated carriers from the bulk to the surface, and the crystalline structure facilitated photogenerated charge transfer and separation, thus enhancing the overall photocatalytic performance. High reactivity and selectivity, good functionality tolerance, and broad reaction scope were achieved by this concerted photocatalysis system. The results contribute to the development of highly efficient semiconductor photocatalysts and synergistic redox reaction systems based on PWST for high-value-added fine chemical production.

Preparation of tungstophosphoric acid/cerium-doped NH2-UiO-66 Z-scheme photocatalyst: a new candidate for green photo-oxidation of dibenzothiophene and quinoline using molecular oxygen as the oxidant

Fakhri, Hanieh,Esrafili, Ali,Farzadkia, Mahdi,Boukherroub, Rabah,Srivastava, Varsha,Sillanp??, Mika

, p. 10897 - 10906 (2021/06/27)

The goal of this study was to introduce an effective visible-light induced photocatalytic system with a good ability for photocatalytic oxidative desulfurization (PODS) and denitrogenation (PODN) using molecular oxygen (O2) as an oxidant. In this regard, tungestophosphoric acid (PW12) was supported onto cerium-doped NH2-UiO-66 (PW12/Ce-NUiO-66) and employed for the photo-oxidation of dibenzothiophene (DBT) and quinoline (Qu). Herein, using cerium (Ce) as a “mediator” facilitated the separation of charge carriers, while NH2-UiO-66 remarkably enhanced the surface area with plentiful adsorption sites and shifted the adsorption edge of PW12to the visible region. The sum of these factors resulted in superior photocatalytic ability and maximum efficiency of 99 ± 1% was achieved by using 30PW12/Ce-NUiO-66 as the optimum photocatalyst in the PODN system and 89 ± 1% in the PODS system under visible light irradiation for 90 min. The traditional Z-scheme mechanism was proposed as the main pathway for this photocatalytic system.

Palladium-Catalyzed Reductive Carbonylation of (Hetero) Aryl Halides and Triflates Using Cobalt Carbonyl as CO Source

Dogga, Bhushanarao,Joseph, Jayan T.,Kumar, C. S. Ananda

supporting information, p. 309 - 313 (2020/12/23)

An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co2(CO)8 and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.

Partial photocatalytic oxidations of 3-pyridinemethanol and 3-picoline by TiO2 prepared in HCl, HNO3 and H2SO4 at different temperatures

?etinkaya, S?d?ka,Yurdakal, Sedat

, p. 237 - 247 (2020/12/13)

Home prepared TiO2 photocatalysts were prepared from TiCl4 precursor in the absence and presence of HCl (1?6 M), HNO3 (1 M) or H2SO4 (1 M) at room temperature (RT), 60 or 100 °C. The TiO2 catalysts were characterised by XRD, BET, SEM and TGA techniques. TiO2 catalyst could not form at low temperature (up to 60 °C) in the presence of H2SO4. Just rutile phase was obtained for all TiO2 samples prepared at RT and 60 °C in HCl or HNO3. At 100 °C mainly both brookite and rutile phases were obtained in the presence of HCl or HNO3, whilst mainly anatase phase appeared in the presence of H2SO4. Nanorod structured TiO2 was formed in the presence of 1 M HCl or HNO3 at RT and 60 °C. The prepared TiO2 catalysts were used for partial oxidation of 3-pyridinemethanol to 3-pyridinemethanal and vitamin B3 in water under UVA irradiation. Moreover, photocatalytic oxidation of 3-picoline, precursor of 3-pyridinemethanol, was also performed, but much lower product selectivity values were obtained with respect to 3-pyridinemethanol oxidation. However, selective 3-picoline oxidation could be performed at pH 2 with low activity. Degussa P25 was used for comparison and almost all home prepared catalysts showed a higher selectivity, but they showed to be less active than Degussa P25. The high selectivity of the home prepared samples was not due to the type of TiO2 phase, but mainly to the hydrophilicity of the TiO2 surface which allowed desorption of valuable products instead of their over-oxidation.

Process route upstream and downstream products

Process route

3-hydroxymethylpyridin
100-55-0

3-hydroxymethylpyridin

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

Conditions
Conditions Yield
With ammonia; oxygen; In tetrahydrofuran; at 120 ℃; for 6h; under 4560.31 Torr;
3-Methylpyridine
108-99-6

3-Methylpyridine

pyridine
110-86-1

pyridine

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

nicotinic acid
59-67-6

nicotinic acid

Conditions
Conditions Yield
With vanadia-titania catalyst; at 250 ℃; under 760.051 Torr; Reagent/catalyst; Mechanism; Gas phase; Flow reactor;
3-(azidomethyl)pyridine
864528-33-6

3-(azidomethyl)pyridine

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

Conditions
Conditions Yield
With Al2O3-supported ruthenium hydroxide; air; In toluene; at 80 ℃; for 24h; under 760.051 Torr;
66 %Chromat.
6 %Chromat.
N-(3-pyridylmethylidene)tert-butylamine
56752-28-4

N-(3-pyridylmethylidene)tert-butylamine

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

7-methyl-[1,6]naphthyridine
99839-11-9

7-methyl-[1,6]naphthyridine

3-methyl-[2,7]naphthyridine
108994-74-7

3-methyl-[2,7]naphthyridine

6-methyl-[1,7]naphthyridine
1260841-18-6

6-methyl-[1,7]naphthyridine

1,2-dimethylpyrrolo<2,3-b>pyridine
113975-38-5

1,2-dimethylpyrrolo<2,3-b>pyridine

3-methyl-[1,8]naphthyridine
14759-22-9

3-methyl-[1,8]naphthyridine

3-methyl-[2,6]naphthyridine
35968-89-9

3-methyl-[2,6]naphthyridine

1,2-dimethyl-1H-pyrrolo[3,2-c]pyridine
680859-99-8

1,2-dimethyl-1H-pyrrolo[3,2-c]pyridine

Conditions
Conditions Yield
at 800 ℃; under 7.50075E-05 Torr;
33%
5%
4%
3%
3%
2%
2%
34%
7%
3-Methylpyridine
108-99-6

3-Methylpyridine

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

3-hydroxymethylpyridin
100-55-0

3-hydroxymethylpyridin

nicotinic acid
59-67-6

nicotinic acid

carbon dioxide
124-38-9,18923-20-1

carbon dioxide

Conditions
Conditions Yield
With oxygen; In water; at 25 ℃; for 3h; pH=7; Reagent/catalyst; pH-value; Kinetics; UV-irradiation;
3-nitrooxymethylpyridine
13469-94-8

3-nitrooxymethylpyridine

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

3-hydroxymethylpyridin
100-55-0

3-hydroxymethylpyridin

Conditions
Conditions Yield
With sodium methylate; In methanol; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
diethyl ether
60-29-7,927820-24-4

diethyl ether

N,N-diethylnicotinamide
59-26-7

N,N-diethylnicotinamide

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

3-hydroxymethylpyridin
100-55-0

3-hydroxymethylpyridin

Conditions
Conditions Yield
at -15 ℃;
3-pyridylcarbinol-N-oxide
6968-72-5

3-pyridylcarbinol-N-oxide

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

3-hydroxymethylpyridin
100-55-0

3-hydroxymethylpyridin

Conditions
Conditions Yield
With 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In acetonitrile; at 150 ℃; for 1h; chemoselective reaction; Microwave irradiation;
66%
20%
3-iodopyridine
1120-90-7

3-iodopyridine

carbon monoxide
201230-82-2

carbon monoxide

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

Conditions
Conditions Yield
With sodium formate; In N,N-dimethyl-formamide; at 110 ℃; for 8h; under 760.051 Torr;
80%
With sodium formate; In N,N-dimethyl-formamide; at 100 ℃; for 10h; under 760.051 Torr;
79%
With palladium(II) acetylacetonate; N,N,N,N,-tetramethylethylenediamine; hydrogen; bis-diphenylphosphinomethane; In toluene; at 100 ℃; for 10h; under 7500.75 Torr; Autoclave;
78%
With rhodium(III) chloride trihydrate; hydrogen; triethylamine; triphenylphosphine; In N,N-dimethyl acetamide; at 90 ℃; for 12h; under 7500.75 Torr; Autoclave;
71%
With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; formic acid; In N,N-dimethyl-formamide; at 50 ℃; for 5h; under 760 Torr; Electrolysis;
35 % Chromat.
With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); sodium carbonate; In N,N-dimethyl-formamide; 1,3,5-trimethyl-benzene; at 60 ℃; for 18h; under 2250.23 Torr; Sealed tube;
100 %Chromat.
nicotinic acid
59-67-6

nicotinic acid

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

Conditions
Conditions Yield
With methylphenylsilane; 2,2-dimethylpropanoic anhydride; Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium(0); In toluene; at 60 ℃; for 20h; Schlenk technique; Inert atmosphere;
60%
With pyridine; lithium tri(t-butoxy)aluminum hydride; N,N-dimethylchloromethyleniminium chloride; copper(l) iodide; 1) CH3CN - THF, -30 deg C, 1 h, 2) -78 deg C, 10 min; dimethylchloromethyleniminium chloride is prepared previously in situ from oxalylchloride and DMF.;
55%
With nickel(II) bromide dimethoxyethane; 1,10-Phenanthroline; methyldiphenylsilane; propionic acid anhydride; In tetrahydrofuran; at 120 ℃; for 15h; Schlenk technique; Inert atmosphere;
55%
With lithium triethylborohydride; <(chlorosulfinyloxy)methylene>dimethylammonium chloride; triethylamine; lithium iodide; Yield given. Multistep reaction; 1.) THF, MeCN, -30 deg C, 1 h, 2.) THF, MeCN, -78 deg C, 15 min;
With hydrogen; 2,2-dimethylpropanoic anhydride; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 80 ℃; for 24h; under 22501.8 Torr;
99 % Spectr.
With hydrogen; 2,2-dimethylpropanoic anhydride; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 80 ℃; for 24h; under 22501.8 Torr;
99 % Spectr.
Multi-step reaction with 2 steps
1: thionyl chloride / 5 h / Heating
2: Bu3SnH / Pd(PPh3)4 / tetrahydrofuran / Ambient temperature
With thionyl chloride; tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran;

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