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Cas Database

541-73-1

541-73-1

Identification

  • Product Name:1,3-Dichlorobenzene

  • CAS Number: 541-73-1

  • EINECS:208-792-1

  • Molecular Weight:147.004

  • Molecular Formula: C6H4Cl2

  • HS Code:2903.69 Oral rat LD50: 500 mg/kg

  • Mol File:541-73-1.mol

Synonyms:Benzene,m-dichloro- (8CI);2,4-Dichlorobenzene;2,6-Dichlorobenzene;m-Dichlorobenzene;m-Dichlorobenzol;NSC 8754;m-Phenylenedichloride;

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Safety information and MSDS view more

  • Pictogram(s):HarmfulXn,DangerousN,ToxicT,FlammableF

  • Hazard Codes:Xn,N,T,F

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowedH411 Toxic to aquatic life with long lasting effects

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled Fresh air, rest. Refer for medical attention. In case of skin contact Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . In case of eye contact First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. If swallowed Rinse mouth. Refer for medical attention . INHALATION: Causes headache, drousiness, unsteadiness. Irritating to mucous membranes. EYES: Severe irritation. SKIN: Severe irritation. INGESTION: Irritation of gastric mucosa, nausea, vomiting, diarrhea, abdominal cramps and cyanosis. (USCG, 1999) /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Lindane and related compounds/

  • Fire-fighting measures: Suitable extinguishing media WATER, FOAM, CARBON DIOXIDE, DRY CHEM ... Special Hazards of Combustion Products: Irritating vapors including hydrogen chloride are produced. (USCG, 1999) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Apply "universal" gelling agent to immobilize spill. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ /o-Dichlorobenzene/ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. /p-Dichlorobenzene/

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Provision to contain effluent from fire extinguishing. Separated from strong oxidants, aluminium and food and feedstuffs. Well closed. Store in an area without drain or sewer access.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TRC
  • Product Description:1,3-Dichlorobenzene
  • Packaging:500g
  • Price:$ 365
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:1,3-Dichlorobenzene
  • Packaging:25G
  • Price:$ 19
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  • Manufacture/Brand:TCI Chemical
  • Product Description:1,3-Dichlorobenzene
  • Packaging:500G
  • Price:$ 67
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:1,3-Dichlorobenzene solution certified reference material, 5000?μg/mL in methanol
  • Packaging:1 mL
  • Price:$ 41.4
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:1,3-Dichlorobenzene solution certified reference material, 5000 μg/mL in methanol
  • Packaging:40214
  • Price:$ 40.1
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:1,3-Dichlorobenzene 98%
  • Packaging:100g
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:1,3-Dichlorobenzene for synthesis
  • Packaging:5 mL
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:1,3-Dichlorobenzene
  • Packaging:8032250005
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Relevant articles and documentsAll total 96 Articles be found

-

Lobry de Bruyn

, (1894)

-

Facile Synthesis of a Fully Fused, Three-Dimensional ?-Conjugated Archimedean Cage with Magnetically Shielded Cavity

Han, Yi,Jiao, Tianyu,Li, Zhengtao,Ni, Yong,Wu, Jishan,Wu, Shaofei,Zhang, Qiuyu,Zhu, Jun

supporting information, p. 14314 - 14321 (2021/09/13)

The synthesis of molecular cages consisting of fully fused, ?-conjugated rings is rare due to synthetic challenges including preorganization, large strain, and poor solubility. Herein, we report such an example in which a tris-2-aminobenzophenone precursor undergoes acid-mediated self-condensation to form a truncated tetrahedron, one of the 13 Archimedean solids. Formation of eight-membered [1,5]diazocine rings provides preorganization and releases the strain while still maintains weak ?-conjugation of the backbone. Thorough characterizations were performed by X-ray, NMR, and UV-vis analysis, assisted by theoretical calculations. The cage exhibits a rigid backbone structure with a well-defined cavity that confines a magnetically shielded environment. The solvent molecule, o-dichlorobenzene, is precisely encapsulated in the cavity at a 1:1 ratio with multiple ?···?, C-H···?, and halogen···πinteractions with the cage skeleton, implying its template effect for the cage closing reaction. Our synthetic strategy opens the opportunity to access more complex, fully fused, three-dimensional ?-conjugated cages.

Exploiting a silver-bismuth hybrid material as heterogeneous noble metal catalyst for decarboxylations and decarboxylative deuterations of carboxylic acids under batch and continuous flow conditions

?tv?s, Sándor B.,Fül?p, Ferenc,Kónya, Zoltán,Kukovecz, ákos,Márton, András,Mészáros, Rebeka,Pálinkó, István,Szabados, Márton,Varga, Gábor

, p. 4685 - 4696 (2021/07/12)

Herein, we report novel catalytic methodologies for protodecarboxylations and decarboxylative deuterations of carboxylic acids utilizing a silver-containing hybrid material as a heterogeneous noble metal catalyst. After an initial batch method development, a chemically intensified continuous flow process was established in a simple packed-bed system which enabled gram-scale protodecarboxlyations without detectable structural degradation of the catalyst. The scope and applicability of the batch and flow processes were demonstrated through decarboxylations of a diverse set of aromatic carboxylic acids. Catalytic decarboxylative deuterations were achieved on the basis of the reaction conditions developed for the protodecarboxylations using D2O as a readily available deuterium source.

Efficient synthesis method of meta-fluoranisole (by machine translation)

-

Paragraph 0026; 0030; 0036; 0040; 0046; 0050; 0056; 0060, (2020/06/05)

The method is characterized by comprising the following steps: taking m-chloronitrobenzene as a raw material, carrying out high-temperature chlorination reaction, nitration reaction and fluorination reaction to obtain 2,4 - 2,4 -difluorobenzene and carrying out a methoxylation reaction with m-difluorobenzene as a raw material and carrying out methoxylation reaction to obtain m-fluorobenzyl ether; and the hydrogenation catalyst is a porous alumina loaded NiO-Co222O3-MoOO3 composite catalyst. The method disclosed by the invention is simple in process and high in product yield. (by machine translation)

Hydrodebromination of Aromatic Bromides Catalyzed by Unsupported Nanoporous Gold: Heterolytic Cleavage of Hydrogen Molecule

Bao, Ming,Feng, Xiujuan,Yamamoto, Yoshinori,Zhang, Sheng,Zhao, Yuhui

, p. 4951 - 4957 (2020/09/09)

Unsupported nanoporous gold (AuNPore) is a highly efficient, practically applicable, and recyclable catalyst for hydrodebromination of aromatic bromides. The AuNPore-catalyzed hydrodebromination of aromatic bromides proceeded smoothly at relatively low hydrogen pressure and temperature to achieve good to excellent yields of the corresponding non-bromine variants. The selective hydrodebromination reaction occurred exclusively in the coexistence of chlorine atom. For the first time, a mechanistic study revealed that the H?H bond splits in a heterolysis manner on the surface of AuNPore to generate Au?H hydride species.

Direct Stereoselective β-Arylation of Enol Ethers by a Decarboxylative Heck-Type Reaction

Hachem, Mahmoud,Hoarau, Christophe,Schneider, Cédric

, (2020/04/15)

Despite remarkable advances to promote regio- and stereoselective decarboxylative arylation of inactivated olefins with benzoic acid derivatives, methodologies involving hetero-substituted alkenes are still lacking. Herein, PdII-catalyzed decarboxylative Heck coupling of α-alkoxyacrylates with (hetero)aryl carboxylic acids for the stereocontrolled production of (Z)-β-heteroarylated vinyl ethers is reported. This methodology offers a rational and step-economical route to the synthesis of attractive β-arylated α-alkoxy α,β-unsaturated carboxylates family which emerged as a relevant class of building blocks with different applications. Mechanistically, whereas electron rich benzoic acids undergo a PdII-catalyzed decarboxylation, electron-deficient substrates proceed through silver(I)-mediated decarboxylation, explaining thus the formation of stereoisomers (E) and (Z) of β-arylated vinyl ethers in presence of these latter.

Process route upstream and downstream products

Process route

C<sub>17</sub>H<sub>15</sub>ClO<sub>5</sub>
84648-17-9

C17H15ClO5

4-Methoxystyrene
637-69-4,24936-44-5

4-Methoxystyrene

C<sub>15</sub>H<sub>15</sub>ClO
84648-30-6

C15H15ClO

3-Chloro-benzoic acid 2-(4-methoxy-phenyl)-ethyl ester
84648-24-8

3-Chloro-benzoic acid 2-(4-methoxy-phenyl)-ethyl ester

1-(2-Chloroethyl)-4-methoxybenzene
18217-00-0

1-(2-Chloroethyl)-4-methoxybenzene

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

Conditions
Conditions Yield
In various solvent(s); at 100 ℃; Mechanism; CIDNP, thermolyse;
C<sub>16</sub>H<sub>13</sub>ClO<sub>4</sub>
84648-15-7

C16H13ClO4

3-chloro-bibenzyl
34176-92-6

3-chloro-bibenzyl

2-phenylethyl chloride
622-24-2

2-phenylethyl chloride

3-Chloro-benzoic acid phenethyl ester
84648-22-6

3-Chloro-benzoic acid phenethyl ester

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

Conditions
Conditions Yield
In various solvent(s); at 100 ℃; Mechanism; CIDNP, thermolyse;
municipal waste

municipal waste

Pentachlorophenol
87-86-5,67471-28-7

Pentachlorophenol

para-dichlorobenzene
106-46-7,84348-21-0

para-dichlorobenzene

chlorobenzene
108-90-7

chlorobenzene

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

Conditions
Conditions Yield
With oxygen; at 350 ℃; Further byproducts given. Title compound not separated from byproducts; Formation of xenobiotics;
1,3,5-trichlorobenzene
108-70-3,63697-19-8

1,3,5-trichlorobenzene

carbon dioxide
124-38-9,18923-20-1

carbon dioxide

3,5-dichlorobenzoic acid
51-36-5

3,5-dichlorobenzoic acid

chlorobenzene
108-90-7

chlorobenzene

3-chlorobenzoate
535-80-8

3-chlorobenzoate

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

Conditions
Conditions Yield
With tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 5 ℃; Yield given. Yields of byproduct given; electrolysis (I=0.4 A);
2,2',4,4'-Tetrachlorobiphenyl
2437-79-8

2,2',4,4'-Tetrachlorobiphenyl

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

Conditions
Conditions Yield
With diethyl ether; copper dichloride;
sodium thiophenolate
930-69-8

sodium thiophenolate

2,6-dichlorobenzenediazonium o-benzenedisulfonimide

2,6-dichlorobenzenediazonium o-benzenedisulfonimide

diphenyldisulfane
882-33-7

diphenyldisulfane

sodium o-benzenedisulfonimide

sodium o-benzenedisulfonimide

(2,6-dichlorophenyl)(phenyl)sulfane

(2,6-dichlorophenyl)(phenyl)sulfane

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

Conditions
Conditions Yield
In methanol; at 20 - 25 ℃;
47%
40%
35%
2,6-dichlorobenzoic acid
50-30-6

2,6-dichlorobenzoic acid

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

Conditions
Conditions Yield
With silver(I) acetate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 16h; Inert atmosphere;
76%
With acetamide; at 225 - 235 ℃;
With silver carbonate; In dimethylsulfoxide-d6; at 120 ℃; for 16h; Sealed vessel;
96 %Spectr.
With silver carbonate; In 1,4-dioxane; at 130 ℃; for 24h;
2,4 dichlorobenzoic acid
50-84-0

2,4 dichlorobenzoic acid

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

Conditions
Conditions Yield
With [Au(1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene)(O2CAd)]; In toluene; at 140 ℃; for 20h;
93%
With silver(I) acetate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 16h; Inert atmosphere;
74%
With C38H53AuN2O2; at 120 ℃;
With potassium hydroxide; In N,N-dimethyl-formamide; at 110 ℃; for 24h; chemoselective reaction; Schlenk technique;
1,2,3-trichlorobenzene
87-61-6

1,2,3-trichlorobenzene

chlorobenzene
108-90-7

chlorobenzene

1,2-dichloro-benzene
95-50-1

1,2-dichloro-benzene

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

Conditions
Conditions Yield
With 3% Pd/C; hydrogen; sodium hydroxide; In dimethyl sulfoxide; at 100 - 130 ℃; for 5h; under 7500.75 Torr; Pressure;
meta-dinitrobenzene
99-65-0

meta-dinitrobenzene

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

Conditions
Conditions Yield
With chlorine; at 220 ℃; Ausschluss von Wasser und Eisen;
With tetrachloromethane; at 260 - 310 ℃;
With chlorine; at 230 - 250 ℃;
With chlorine; at 230 ℃; Temperature;

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  • Chemwill Asia Co., Ltd.
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