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Cas Database

98-09-9

98-09-9

Identification

  • Product Name:Benzenesulfonyl chloride

  • CAS Number: 98-09-9

  • EINECS:202-636-6

  • Molecular Weight:176.624

  • Molecular Formula: C6H5ClO2S

  • HS Code:2908.20 DERIVATION

  • Mol File:98-09-9.mol

Synonyms:Benzenesulfochloride;Benzenesulfonic chloride;NSC 2864;Phenylsulfonyl chloride;

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Safety information and MSDS view more

  • Pictogram(s):CorrosiveC

  • Hazard Codes:C

  • Signal Word:Danger

  • Hazard Statement:H314 Causes severe skin burns and eye damage

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. May be fatal if inhaled, swallowed or absorbed through skin. Contact may cause skin and eye burns. Irritating to eyes, skin and mucous membranes. INGESTION: May cause abdominal spasm and vomiting. (USCG, 1999)

  • Fire-fighting measures: Suitable extinguishing media Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: Note: Most foams will react with the material and release corrosive/toxic gases. SMALL FIRE: CO2, dry chemical, dry sand, alcohol-resistant foam. LARGE FIRE: Water spray, fog or alcohol-resistant foam. FOR CHLOROSILANES, DO NOT USE WATER; use AFFF alcohol-resistant medium-expansion foam. Move containers from fire area if you can do it without risk. Use water spray or fog; do not use straight streams. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016) Special Hazards of Combustion Products: May contain highly toxic and irritating hydrogen chloride and oxides of chlorine and sulfur. Behavior in Fire: Cylinder may explode. Decomposes to produce highly toxic chlorine and sulfur compounds. Reacts with hot water to produce highly toxic and corrosive hydrochloric acid and benzenesulfonic acid. (USCG, 1999) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Manufacture/Brand:TRC
  • Product Description:Benzenesulfonyl chloride
  • Packaging:25g
  • Price:$ 130
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:Benzenesulfonyl Chloride >99.0%(GC)(T)
  • Packaging:500g
  • Price:$ 34
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Benzenesulfonyl Chloride [for Determination of Hippuric Acid] >99.0%(GC)(T)
  • Packaging:25g
  • Price:$ 34
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Benzenesulfonyl Chloride >99.0%(GC)(T)
  • Packaging:25g
  • Price:$ 14
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Benzenesulfonyl chloride
  • Packaging:25 g
  • Price:$ 12
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Benzenesulfonyl chloride
  • Packaging:100 g
  • Price:$ 20
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Benzenesulfonyl chloride for HPLC derivatization
  • Packaging:100ml
  • Price:$ 43.7
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Benzenesulfonyl chloride 99%
  • Packaging:100g
  • Price:$ 36
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Benzenesulfonyl chloride 96%
  • Packaging:1kg
  • Price:$ 77.5
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Benzenesulfonyl chloride 99%
  • Packaging:500g
  • Price:$ 71.2
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Relevant articles and documentsAll total 79 Articles be found

-

Wittmann et al.

, p. 734 (1969)

-

On the reactivity of (7-oxabicyclo[2.2.1]hept-5-en-2-ylidene)amines. Different reaction paths leading to the same final products

Arjona, Odon,Csaky, Aurelio G.,Murcia, M. Carmen,Plumet, Joaquin

, p. 3667 - 3672 (2001)

The reaction of amines, N-substituted by a 7-oxabicycIo[2.2.1]hept-5-en-2-ylidene moiety, either with PhSCl or mCPBA (meta-chloroperbenzoic acid) unexpectedly afforded the same type of furan derivatives by two different reaction paths. The results confirm the intervention of a homoconjugative, electron-releasing effect of the oxabicycloalkenylideneamine moieties, as predicted theoretically.

Copper-Catalyzed N-Directed Distal C(sp3)-H Sulfonylation and Thiolation with Sulfinate Salts

Chen, Guang-Le,He, Shi-Hui,Cheng, Liang,Liu, Feng

supporting information, p. 8338 - 8342 (2021/10/25)

We herein report a selective and catalytic C(sp3)-H functionalization approach to access amines bearing organo-sulfonyl and organo-thiol groups. This reaction proceeds through a cascade process of N-radical formation, alkyl radical formation via 1,5-HAT, and C-S bond formation, thereby offering a series of functionalized amines. This method could enable primary, secondary, and tertiary C(sp3)-H sulfonylation and thiolation and also exhibits good functional group tolerance.

Chromoselective Synthesis of Sulfonyl Chlorides and Sulfonamides with Potassium Poly(heptazine imide) Photocatalyst

Antonietti, Markus,Guldi, Dirk M.,Markushyna, Yevheniia,Savateev, Aleksandr,Schü?lbauer, Christoph M.,Ullrich, Tobias

supporting information, p. 20543 - 20550 (2021/08/12)

Among external stimuli used to promote a chemical reaction, photocatalysis possesses a unique one—light. Photons are traceless reagents that provide an exclusive opportunity to alter chemoselectivity of the photocatalytic reaction varying the color of incident light. This strategy may be implemented by using a sensitizer capable to activate a specific reaction pathway depending on the excitation light. Herein, we use potassium poly(heptazine imide) (K-PHI), a type of carbon nitride, to generate selectively three different products from S-arylthioacetates simply varying the excitation light and otherwise identical conditions. Namely, arylchlorides are produced under UV/purple, sulfonyl chlorides with blue/white, and diaryldisulfides at green to red light. A combination of the negatively charged polyanion, highly positive potential of the valence band, presence of intraband states, ability to sensitize singlet oxygen, and multi-electron transfer is shown to enable this chromoselective conversion of thioacetates.

Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides

Chen, Rongxiang,Xu, Shaohong,Shen, Fumin,Xu, Canran,Wang, Kaikai,Wang, Zhanyong,Liu, Lantao

, (2021/09/20)

A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.

Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases

Millies, Benedikt,Von Hammerstein, Franziska,Gellert, Andrea,Hammerschmidt, Stefan,Barthels, Fabian,G?ppel, Ulrike,Immerheiser, Melissa,Elgner, Fabian,Jung, Nathalie,Basic, Michael,Kersten, Christian,Kiefer, Werner,Bodem, Jochen,Hildt, Eberhard,Windbergs, Maike,Hellmich, Ute A.,Schirmeister, Tanja

, p. 11359 - 11382 (2019/12/24)

The NS2B/NS3 serine proteases of the Zika and Dengue flaviviruses are attractive targets for the development of antiviral drugs. We report the synthesis and evaluation of a new, proline-based compound class that displays allosteric inhibition of both proteases. The structural features relevant for protease binding and inhibition were determined to establish them as new lead compounds for flaviviral inhibitors. Based on our structure-activity relationship studies, the molecules were further optimized, leading to inhibitors with submicromolar IC50 values and improved lipophilic ligand efficiency. The allosteric binding site in the proteases was probed using mutagenesis and covalent modification of the obtained cysteine mutants with maleimides, followed by computational elucidation of the possible binding modes. In infected cells, antiviral activity against Dengue virus serotype 2 using prodrugs of the inhibitors was observed. In summary, a novel inhibitor scaffold targeting an allosteric site shared between flaviviral NS2B/NS3 proteases is presented whose efficacy is demonstrated in vitro and in cellulo.

Preparation method for symmetric diaryl disulfide

-

Paragraph 0038; 0039; 0040; 0041, (2019/04/17)

The invention discloses a preparation method for symmetric diaryl disulfide. The preparation method comprises the following steps: using aromatic hydrocarbon as shown in a general formula (I) as a rawmaterial and reacting with chlorosulfonic acid to generate aryl chlorosulfonic acid, and reacting with sulfoxide chloride to synthesize aryl sulfonyl chloride as shown in a general formula (II); andpreparing the symmetric diaryl disulfide as shown in a general formula (III) under the action of a reducing agent through a reduction reaction by the aryl sulfonyl chloride as shown in the general formula (II). The disclosed preparation method for the symmetric diaryl disulfide has many advantages of low toxicity of the reaction raw material, short reaction time, cheap reagents and easy acquisition, convenient separation and purification and the like, and has very high application value and industrial production value.

Process route upstream and downstream products

Process route

<i>N</i>,<i>N</i>-dimethyl-aniline
121-69-7,77733-26-7

N,N-dimethyl-aniline

N,N,N',N'-tetramethylbenzidine
366-29-0

N,N,N',N'-tetramethylbenzidine

4-fluoro-N,N-dimethylaniline
403-46-3

4-fluoro-N,N-dimethylaniline

2-fluoro-N,N-dimethylaniline
393-56-6

2-fluoro-N,N-dimethylaniline

1-chloro-2-(dimethylamino)benzene
698-01-1

1-chloro-2-(dimethylamino)benzene

4-(methylamino)benzaldehyde
556-21-8

4-(methylamino)benzaldehyde

4,4'-methylene-bis(N,N-dimethylaniline)
101-61-1

4,4'-methylene-bis(N,N-dimethylaniline)

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
Conditions Yield
With zirconium(IV) chloride; N-fluorobis(benzenesulfon)imide; In chloroform; for 5h; Reflux;
6%
N-chloro-succinimide
128-09-6

N-chloro-succinimide

ethanol
64-17-5

ethanol

Benzyl phenyl sulfide
831-91-4

Benzyl phenyl sulfide

ethyl benzenesulfinate
1859-03-6

ethyl benzenesulfinate

benzyl chloride
100-44-7

benzyl chloride

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
Conditions Yield
In dichloromethane; for 18h; Product distribution; Ambient temperature;
30%
N-chloro-succinimide
128-09-6

N-chloro-succinimide

Benzyl phenyl sulfide
831-91-4

Benzyl phenyl sulfide

benzyl alcohol
100-51-6,185532-71-2

benzyl alcohol

benzyl chloride
100-44-7

benzyl chloride

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
Conditions Yield
In dichloromethane; for 18h; Product distribution; Ambient temperature;
42%
thiophenol
108-98-5

thiophenol

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

diphenyldisulfane
882-33-7

diphenyldisulfane

Conditions
Conditions Yield
With potassium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In water; at 20 ℃; for 10h; Reagent/catalyst;
68%
22%
S-Phenyl benzenethiosulfonate
1212-08-4

S-Phenyl benzenethiosulfonate

benzenesulfenyl chloride
931-59-9

benzenesulfenyl chloride

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

diphenyldisulfane
882-33-7

diphenyldisulfane

Conditions
Conditions Yield
In N,N-dimethyl-formamide; at 115 ℃; for 24h; Mechanism;
88.7%
sodium benzenesulfonate
873-55-2

sodium benzenesulfonate

sodium phenylsulfonate
515-42-4

sodium phenylsulfonate

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
Conditions Yield
With sodium hypochlorite; In water; pH=10; pH-value; Kinetics; Mechanism; aq. phosphate buffer;
<i>N</i>-benzenesulfonyl-acetimidoyl chloride
860743-29-9

N-benzenesulfonyl-acetimidoyl chloride

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

acetonitrile
75-05-8,26809-02-9

acetonitrile

Conditions
Conditions Yield
N,N-dimethyl-1-naphthalenamine
86-56-6,112790-02-0,651316-60-8

N,N-dimethyl-1-naphthalenamine

benzenesulfonamide
98-10-2

benzenesulfonamide

S-Phenyl benzenethiosulfonate
1212-08-4

S-Phenyl benzenethiosulfonate

phenylsulfonyl fluoride
368-43-4

phenylsulfonyl fluoride

2-fluoro-N,N-dimethylnaphthalene-1-amine

2-fluoro-N,N-dimethylnaphthalene-1-amine

N<sup>4</sup>,N<sup>4</sup>,N<sup>4'</sup>,N<sup>4'</sup>-tetramethyl-[1,1'-binaphthalene]-4,4'-diamine
34614-42-1

N4,N4,N4',N4'-tetramethyl-[1,1'-binaphthalene]-4,4'-diamine

4,4'-methylenebis(N,N-dimethylnaphthalen-1-amine)
98659-68-8

4,4'-methylenebis(N,N-dimethylnaphthalen-1-amine)

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
Conditions Yield
With N-fluorobis(benzenesulfon)imide; In chloroform; at 25 ℃; for 10h;
chlorosulfonic acid
7790-94-5

chlorosulfonic acid

diphenyl sulphone
127-63-9

diphenyl sulphone

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

benzenesulfonic acid
98-11-3

benzenesulfonic acid

Conditions
Conditions Yield
at -40 ℃; und +25grad und +90grad;
at -8 - -5 ℃;
at 15 ℃;
phenyl thiobenzoate
884-09-3

phenyl thiobenzoate

hydrogenchloride
7647-01-0,15364-23-5

hydrogenchloride

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

benzoic acid
65-85-0,8013-63-6

benzoic acid

benzenesulfonic acid
98-11-3

benzenesulfonic acid

Conditions
Conditions Yield

Global suppliers and manufacturers

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  • Simagchem Corporation
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  • Amadis Chemical Co., Ltd.
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  • Emails:sales@amadischem.com
  • Main Products:29
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  • Chemwill Asia Co., Ltd.
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