Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1493-27-2

Post Buying Request

1493-27-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1493-27-2 Usage

Chemical Properties

clear yellow to brownish liqui

Uses

Different sources of media describe the Uses of 1493-27-2 differently. You can refer to the following data:
1. o-Nitrofluorobenzene is an intermediate in the synthetic preparations of various pharmaceutical goods.
2. 1-Fluoro-2-nitrobenzene is an intermediate in the synthetic preparations of various pharmaceutical goods.

Synthesis Reference(s)

Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8Tetrahedron Letters, 26, p. 2233, 1985 DOI: 10.1016/S0040-4039(00)98970-6

Check Digit Verification of cas no

The CAS Registry Mumber 1493-27-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,9 and 3 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1493-27:
(6*1)+(5*4)+(4*9)+(3*3)+(2*2)+(1*7)=82
82 % 10 = 2
So 1493-27-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H8BFO3/c1-12-7-3-2-5(8(10)11)4-6(7)9/h2-4,10-11H,1H3

1493-27-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A13852)  1-Fluoro-2-nitrobenzene, 99%   

  • 1493-27-2

  • 50g

  • 265.0CNY

  • Detail
  • Alfa Aesar

  • (A13852)  1-Fluoro-2-nitrobenzene, 99%   

  • 1493-27-2

  • 250g

  • 1033.0CNY

  • Detail
  • Alfa Aesar

  • (A13852)  1-Fluoro-2-nitrobenzene, 99%   

  • 1493-27-2

  • 1000g

  • 3420.0CNY

  • Detail
  • Aldrich

  • (F10801)  1-Fluoro-2-nitrobenzene  99%

  • 1493-27-2

  • F10801-50G

  • 801.45CNY

  • Detail
  • Aldrich

  • (F10801)  1-Fluoro-2-nitrobenzene  99%

  • 1493-27-2

  • F10801-250G

  • 2,459.34CNY

  • Detail

1493-27-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Fluoro-2-nitrobenzene

1.2 Other means of identification

Product number -
Other names 2-nitro fluorobenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1493-27-2 SDS

1493-27-2Synthetic route

2-nitrophenyl bromide
577-19-5

2-nitrophenyl bromide

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With Cu(Ph3P)3F In N,N-dimethyl-formamide at 170℃; for 5h;100%
1,2-Dinitrobenzene
528-29-0

1,2-Dinitrobenzene

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 1.5h; Ambient temperature;100%
With tetrabutyl ammonium fluoride In tetrahydrofuran; water; N,N-dimethyl-formamide at 20℃; for 1h;72%
With tetrabutyl ammonium fluoride In tetrahydrofuran Ambient temperature; Yield given;
With tetraphenylphosphonium hydrogendifluoride In sulfolane at 100℃; for 2h;70 % Chromat.
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1.5h; Inert atmosphere; chemoselective reaction;97.4 %Chromat.
o-fluorophenylboronic acid
1993-03-9

o-fluorophenylboronic acid

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With nitric acid In 1,2-dichloro-ethane at 70℃; for 16h; Inert atmosphere;96%
With N-Bromosuccinimide; [bis(trifluoroacetoxy)iodo]benzene; sodium nitrite In acetonitrile at 20℃; for 3h; regioselective reaction;80%
With N–nitrosuccinimide; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate In acetonitrile at 20℃; for 19h; Inert atmosphere; Irradiation;68%
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C / Sealed tube
1.2: 0.25 h / 20 °C / Sealed tube
2.1: sodium triflate; sodium nitrite / ethyl acetate / 16 h / 70 °C / Sealed tube
View Scheme
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With sulfolane; sodium hydrogencarbonate at 190℃; for 2h;92%
cetyltributylphosphonium bromide
14937-45-2

cetyltributylphosphonium bromide

2-Chloronitrobenzene
88-73-3

2-Chloronitrobenzene

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With potassium fluoride91.2%
2-Chloronitrobenzene
88-73-3

2-Chloronitrobenzene

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With potassium fluoride; polydiallyldimethylammonium chloride In dimethyl sulfoxide at 200℃; for 3h;90.1%
With potassium fluoride; bis(tricyclohexylphosphine)nickel(II) dichloride; tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 150℃; for 8h; Inert atmosphere;79.8%
With potassium fluoride; bis(triphenylphosphine)iminium chloride In dimethyl sulfoxide at 150℃; for 8h; Inert atmosphere;76%
undecyltributylammonium bromide

undecyltributylammonium bromide

2-Chloronitrobenzene
88-73-3

2-Chloronitrobenzene

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With potassium fluoride84.6%
fluorobenzene
462-06-6

fluorobenzene

A

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

B

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With nitric acid at 50℃; for 3h;A 84.4%
B 13.9%
With 2-nitrobenzo[d]isothiazol-3(2H)-one 1,1-dioxide at 55 - 60℃; for 3h; Inert atmosphere; Sealed tube; Overall yield = 96 percent;A 76.8%
B 19.2%
With aluminium trichloride; dinitrogen tetraoxide; Petroleum ether
bis(2-fluorophenyl)iodonium tetrafluoroborate
1034926-54-9

bis(2-fluorophenyl)iodonium tetrafluoroborate

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With sodium triflate; sodium nitrite In ethyl acetate at 70℃; for 16h; Sealed tube;84%
o-nitroiodobenzene
609-73-4

o-nitroiodobenzene

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
Stage #1: o-nitroiodobenzene With phenyllithium In tetrahydrofuran; diethyl ether; cyclohexane at -28℃; Flow reactor;
Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran; diethyl ether; cyclohexane at -28℃; Flow reactor;
83%
cetyltrimethylammonium bromide
1119-97-7

cetyltrimethylammonium bromide

2-Chloronitrobenzene
88-73-3

2-Chloronitrobenzene

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With potassium fluoride In water; toluene78%
thiophene
110-01-0

thiophene

2-Chloronitrobenzene
88-73-3

2-Chloronitrobenzene

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
70%
nitrobenzene
98-95-3

nitrobenzene

A

3-fluoro-1-nitrobenzene
402-67-5

3-fluoro-1-nitrobenzene

B

2,6-difluoro-1-nitrobenzene
19064-24-5

2,6-difluoro-1-nitrobenzene

C

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

D

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With tetrafluoroammonium tetrafluoroborate In hydrogen fluoride at 0℃; Further byproducts given. Title compound not separated from byproducts;A 62%
B n/a
C 6%
D 15%
With tetrafluoroammonium tetrafluoroborate In hydrogen fluoride at 0℃; Yield given. Further byproducts given. Title compound not separated from byproducts;A 62%
B n/a
C 6%
D 15%
With tetrafluoroammonium tetrafluoroborate In hydrogen fluoride at 0℃; Further byproducts given. Title compound not separated from byproducts;A 62 % Spectr.
B n/a
C 6 % Spectr.
D 15 % Spectr.
dimethyl-(2-nitro-phenyl)-sulfonium ; methyl sulfate
13118-30-4

dimethyl-(2-nitro-phenyl)-sulfonium ; methyl sulfate

A

methyl 2-nitrophenyl sulfide
3058-47-7

methyl 2-nitrophenyl sulfide

B

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With cesium fluoride In N,N-dimethyl-formamide at 100℃; for 0.166667h;A 25%
B 56%
o-nitroiodobenzene
609-73-4

o-nitroiodobenzene

A

nitrobenzene
98-95-3

nitrobenzene

B

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
Stage #1: o-nitroiodobenzene With phenyllithium In tetrahydrofuran; diethyl ether; cyclohexane at -28℃; Flow reactor;
Stage #2: With 2-fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide In tetrahydrofuran; diethyl ether; cyclohexane at -28℃; Flow reactor;
A 24%
B 56%
ortho-nitrobenzoic acid
552-16-9

ortho-nitrobenzoic acid

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
Stage #1: ortho-nitrobenzoic acid With tetrakis(acetonitrile)copper(I)tetrafluoroborate; tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 23℃; for 0.5h; Sealed tube; Inert atmosphere;
Stage #2: In acetonitrile at 35℃; Irradiation; Sealed tube; Inert atmosphere;
54%
2-Fluoroaniline
348-54-9

2-Fluoroaniline

trifluoroacetic acid
76-05-1

trifluoroacetic acid

A

2,2,2-trifluoro-N-(2-fluoro-6-hydroxyphenyl)acetamide

2,2,2-trifluoro-N-(2-fluoro-6-hydroxyphenyl)acetamide

B

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

C

2,2'-difluoroazobenzene
401-44-5

2,2'-difluoroazobenzene

Conditions
ConditionsYield
With Oxone In dimethyl sulfoxide at 90℃; Schlenk technique; Inert atmosphere; chemoselective reaction;A 25%
B 15%
C 40%
2-Fluoroaniline
348-54-9

2-Fluoroaniline

trifluoroacetic acid
76-05-1

trifluoroacetic acid

A

2,2,2-trifluoro-N-(2-hydroxyphenyl)acetamide
10595-66-1

2,2,2-trifluoro-N-(2-hydroxyphenyl)acetamide

B

2,2,2-trifluoro-N-(2-fluoro-6-hydroxyphenyl)acetamide

2,2,2-trifluoro-N-(2-fluoro-6-hydroxyphenyl)acetamide

C

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With Oxone In acetonitrile at 90℃; Schlenk technique; Inert atmosphere; chemoselective reaction;A 10%
B 25%
C 8%
2-Fluoroaniline
348-54-9

2-Fluoroaniline

trifluoroacetic acid
76-05-1

trifluoroacetic acid

A

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

B

2,2'-difluoroazobenzene
401-44-5

2,2'-difluoroazobenzene

Conditions
ConditionsYield
With Oxone In N,N-dimethyl-formamide at 90℃; Schlenk technique; Inert atmosphere; chemoselective reaction;A 10%
B 20%
4-cyanophenol
767-00-0

4-cyanophenol

1,2-Dinitrobenzene
528-29-0

1,2-Dinitrobenzene

A

4-(2-nitrophenoxy)benzonitrile
113344-23-3

4-(2-nitrophenoxy)benzonitrile

B

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With potassium fluoride In dimethyl sulfoxide at 110℃; for 2h;A n/a
B 10%
With potassium fluoride In dimethyl sulfoxide at 110℃; for 2h;A n/a
B 10 % Chromat.
2-Fluoroaniline
348-54-9

2-Fluoroaniline

trifluoroacetic acid
76-05-1

trifluoroacetic acid

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With Oxone In dichloromethane at 90℃; Schlenk technique; Inert atmosphere; chemoselective reaction;10%
fluorobenzene
462-06-6

fluorobenzene

nitro acetate
591-09-3

nitro acetate

A

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

B

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

fluorobenzene
462-06-6

fluorobenzene

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With nitric acid; phosphorus pentoxide beim Nitrieren; Trennung vom p-Isomeren durch fraktionierte Destillation und Krystallisation;
4-Fluoro-3-nitroaniline
364-76-1

4-Fluoro-3-nitroaniline

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
Diazotization.nachfolgend Reduktion zu 4-Fluor-3-nitro-phenylhydrazin und Oxydation mit Kupfersulfat;
fluorobenzene
462-06-6

fluorobenzene

methyl nitrate
598-58-3

methyl nitrate

A

3-fluoro-1-nitrobenzene
402-67-5

3-fluoro-1-nitrobenzene

B

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

C

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
Product distribution; gas-phase radiolytic nitration;
fluorobenzene
462-06-6

fluorobenzene

A

3-fluoro-1-nitrobenzene
402-67-5

3-fluoro-1-nitrobenzene

B

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

C

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With silver nitrate; boron trifluoride In acetonitrile at 25℃; for 10h; Product distribution; competitive nitration benzene, relative rate;A 1 % Chromat.
B 72 % Chromat.
C 27 % Chromat.
With methyl nitrate; methane at 37.6℃; Product distribution; Irradiation; gas-phase nitration by radiolytically formed MeO(1+)(H)NO2;
With nitro acetate; H-ZSM-11 In hexane at 30℃; Product distribution; different catalysts;
fluorobenzene
462-06-6

fluorobenzene

A

3-fluoro-1-nitrobenzene
402-67-5

3-fluoro-1-nitrobenzene

B

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With K10 montmorillonite-supported cupric nitrate; acetic anhydride In hexane for 48h; Product distribution; Ambient temperature; var. halobenzenes, other solvent, other time;
4-cyanophenyl methyl ketone
1443-80-7

4-cyanophenyl methyl ketone

1-fluoro-2-nitro-benzene radical anion
34467-51-1, 1493-27-2

1-fluoro-2-nitro-benzene radical anion

A

C9H7NO(1-)

C9H7NO(1-)

B

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
at 149.9℃; Thermodynamic data; ΔG0;
cyclohexylamine
108-91-8

cyclohexylamine

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

N-cyclohexyl-2-nitroaniline
6373-71-3

N-cyclohexyl-2-nitroaniline

Conditions
ConditionsYield
In toluene at 25℃; Rate constant; also in DMSO;100%
In toluene at 25℃;100%
97%
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

methylamine
74-89-5

methylamine

2-nitro-N-methylaniline
612-28-2

2-nitro-N-methylaniline

Conditions
ConditionsYield
In ethanol; water Reflux;100%
In methanol; water Heating;98%
In water at 20℃; for 2h; Inert atmosphere;93%
N,N-dimethylethylenediamine
108-00-9

N,N-dimethylethylenediamine

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

N1,N1-dimethyl-N2-(2-nitrophenyl)ethane-1,2-diamine
25238-55-5

N1,N1-dimethyl-N2-(2-nitrophenyl)ethane-1,2-diamine

Conditions
ConditionsYield
In toluene at 25℃; Rate constant; also in DMSO;100%
In toluene at 25℃;100%
In isopropyl alcohol at 90 - 100℃; for 16h;92%
pyrrolidine
123-75-1

pyrrolidine

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

1-(2-nitrophenyl)pyrrolidine
40832-79-9

1-(2-nitrophenyl)pyrrolidine

Conditions
ConditionsYield
In tetrahydrofuran at 50℃; under 5400430 Torr; for 20h;100%
With potassium carbonate In acetonitrile for 3h; Heating / reflux;100%
With potassium carbonate In acetonitrile at 90℃; for 3h; Inert atmosphere;99%
piperidine
110-89-4

piperidine

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

1-(2-nitrophenyl)piperidine
15822-77-2

1-(2-nitrophenyl)piperidine

Conditions
ConditionsYield
In toluene at 25℃;100%
In toluene at 25℃; Rate constant; Mechanism; also in DMSO;100%
With potassium phosphate; TPGS-750-M In water at 20℃; for 18h; Inert atmosphere;99%
1H-imidazole
288-32-4

1H-imidazole

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

1-(2-nitrophenyl)-1H-imidazole
23309-16-2

1-(2-nitrophenyl)-1H-imidazole

Conditions
ConditionsYield
With 1,2,3-Benzotriazole; potassium tert-butylate; copper(l) iodide In dimethyl sulfoxide at 110℃; for 0.5h;100%
With pyridine; potassium carbonate; copper(II) oxide at 115℃; Ullmann Condensation;96%
With potassium carbonate In acetonitrile for 24h; Heating;95%
1,2,3,4-tetrahydroisoquinoline
91-21-4

1,2,3,4-tetrahydroisoquinoline

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

1,2,3,4-tetrahydro-2-(2-nitrophenyl)isoquinoline
140381-66-4

1,2,3,4-tetrahydro-2-(2-nitrophenyl)isoquinoline

Conditions
ConditionsYield
In neat (no solvent) at 100℃; for 1h;100%
With potassium carbonate In dimethyl sulfoxide at 100℃;81%
With potassium carbonate In N,N-dimethyl-formamide Inert atmosphere; Reflux;60%
2-hydroxybromobenzene
95-56-7

2-hydroxybromobenzene

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

1-(2-bromophenoxy)-2-nitrobenzene
60671-89-8

1-(2-bromophenoxy)-2-nitrobenzene

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 95℃; for 23h;100%
With potassium carbonate In dimethyl sulfoxide at 95℃;95%
With caesium carbonate In N,N-dimethyl-formamide at 0 - 80℃; for 3h;90%
ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

(+/-)-ethyl cyano(2-nitrophenyl)acetate
65548-02-9

(+/-)-ethyl cyano(2-nitrophenyl)acetate

Conditions
ConditionsYield
With sodium hydride In dimethyl sulfoxide 1.) 10 min, 2.) 90 deg C, 0.5 h;100%
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In dimethyl sulfoxide at 20 - 90℃; Inert atmosphere;99%
Stage #1: ethyl 2-cyanoacetate With potassium tert-butylate In tetrahydrofuran for 0.25h; Cooling with ice;
Stage #2: ortho-nitrofluorobenzene In tetrahydrofuran for 3h; Reflux;
96.4%
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
1745-07-9

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

6,7-dimethoxy-(N-2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline
93649-88-8

6,7-dimethoxy-(N-2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
In neat (no solvent) at 100℃; for 1h;100%
With potassium carbonate In dimethyl sulfoxide at 100℃; for 4h;40%
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 12h;
With potassium carbonate In N,N-dimethyl-formamide at 120℃;
methyl 2-(2-acetyl-4,5-dimethoxyphenyl)acetate
17173-27-2

methyl 2-(2-acetyl-4,5-dimethoxyphenyl)acetate

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

methyl 2-[2-(2-nitrophenyl)acetyl]-4,5-dimethoxyphenylacetate
278801-02-8

methyl 2-[2-(2-nitrophenyl)acetyl]-4,5-dimethoxyphenylacetate

Conditions
ConditionsYield
With sulfuric acid In 1,4-dioxane for 2h; Heating;100%
ortho-cresol
95-48-7

ortho-cresol

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

1-methyl-2-(2-nitrophenoxy)benzene
54106-40-0

1-methyl-2-(2-nitrophenoxy)benzene

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 95℃; for 20h;100%
Stage #1: ortho-cresol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;
Stage #2: ortho-nitrofluorobenzene In N,N-dimethyl-formamide at 20 - 50℃; for 13h; Inert atmosphere;
93%
Stage #1: ortho-cresol With potassium tert-butylate In tetrahydrofuran for 1h;
Stage #2: ortho-nitrofluorobenzene In tetrahydrofuran
4-tert-Butylaniline
769-92-6

4-tert-Butylaniline

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

(4-tert-butyl-phenyl)-(2-nitro-phenyl)-amine
188844-98-6

(4-tert-butyl-phenyl)-(2-nitro-phenyl)-amine

Conditions
ConditionsYield
In dimethyl sulfoxide at 100℃;100%
With caesium carbonate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 65℃; for 18h;54%
With triethylamine In N,N-dimethyl-formamide at 80℃; for 12h;
2-(3,4-dimethoxyphenyl)-ethylamine
120-20-7

2-(3,4-dimethoxyphenyl)-ethylamine

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

N-[2-(3,4-dimethoxyphenyl)ethyl]-2-nitroaniline
5761-36-4

N-[2-(3,4-dimethoxyphenyl)ethyl]-2-nitroaniline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 70℃; for 16h;100%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.0966667h; microwave irradiation;
With diisopropylamine In N,N-dimethyl-formamide microwave irradiation;
With potassium carbonate In N,N-dimethyl-formamide at 60℃;
With potassium carbonate In N,N-dimethyl-formamide at 60℃; Microwave irradiation;
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

4-bromo-aniline
106-40-1

4-bromo-aniline

4-bromo-N-(2-nitrophenyl)benzenamine
58476-59-8

4-bromo-N-(2-nitrophenyl)benzenamine

Conditions
ConditionsYield
In dimethyl sulfoxide at 100℃; for 48h; Inert atmosphere; Schlenk technique;100%
With potassium fluoride at 170 - 180℃; for 30h;92%
With potassium fluoride at 150℃; for 18h; Inert atmosphere;90%
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

L-proline
147-85-3

L-proline

(S)-N-(2-nitrophenyl)proline
31981-54-1

(S)-N-(2-nitrophenyl)proline

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol; water for 5h; Heating;100%
With sodium hydrogencarbonate In ethanol; water Heating;94%
With triethylamine In dimethyl sulfoxide80.3%
With sodium hydrogencarbonate In ethanol; water at 100℃;
phenyltrimethylsilyl ether
1529-17-5

phenyltrimethylsilyl ether

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

1-nitro-2-phenoxy-benzene
2216-12-8

1-nitro-2-phenoxy-benzene

Conditions
ConditionsYield
t-Bu-P4 base In hexane; N,N-dimethyl-formamide at 20℃; for 6h;100%
3-amino-2,2-dimethylpropan-1-ol
26734-09-8

3-amino-2,2-dimethylpropan-1-ol

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

2,2-dimethyl-3-(2-nitrophenylamino)propan-1-ol
336106-21-9

2,2-dimethyl-3-(2-nitrophenylamino)propan-1-ol

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃; for 3h;100%
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

hexan-1-ol
111-27-3

hexan-1-ol

1-(hexyloxy)-2-nitrobenzene
67285-54-5

1-(hexyloxy)-2-nitrobenzene

Conditions
ConditionsYield
With triethylsilane; t-Bu-P4 In hexane; dimethyl sulfoxide at 100℃; for 2h;100%
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

(R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester
147081-49-0

(R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester

tert-butyl (R)-3-((2-nitrophenyl)amino)pyrrolidine-1-carboxylate

tert-butyl (R)-3-((2-nitrophenyl)amino)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: ortho-nitrofluorobenzene In N,N-dimethyl-formamide at 80℃; for 16h;
100%
With potassium carbonate In N,N-dimethyl-formamide at 60℃;
3-(1-pyrrolidinyl)propylamine
23159-07-1

3-(1-pyrrolidinyl)propylamine

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

2-Nitro-1-(3-pyrrolidino-propylamino)-benzol
88858-51-9

2-Nitro-1-(3-pyrrolidino-propylamino)-benzol

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;100%
In tetrahydrofuran at 30℃; for 12h; Inert atmosphere;
N,N',N'-trimethylenediamine
142-25-6

N,N',N'-trimethylenediamine

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

N,N,N'-trimethyl-N'-(2-nitrophenyl)-1,2-ethanediamine
371244-16-5

N,N,N'-trimethyl-N'-(2-nitrophenyl)-1,2-ethanediamine

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol at 80℃; for 16h;100%
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate
140645-23-4

1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate

1,1-dimethylethyl (3R)-3-{[(2-nitrophenyl)amino]methyl}-1-piperidinecarboxylate
876590-06-6

1,1-dimethylethyl (3R)-3-{[(2-nitrophenyl)amino]methyl}-1-piperidinecarboxylate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 5h; Heating / reflux;100%
With potassium carbonate In acetonitrile for 5h; Heating / reflux;100%
With potassium carbonate In acetonitrile Reflux;98%
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

L-3-(2-thienyl)alanine
22951-96-8

L-3-(2-thienyl)alanine

(S)-2-(2-nitrophenylamino)-3-(thiophen-2-yl)propanoic acid
911359-29-0

(S)-2-(2-nitrophenylamino)-3-(thiophen-2-yl)propanoic acid

Conditions
ConditionsYield
With potassium carbonate In ethanol; water at 20 - 100℃; for 16h;100%
With potassium carbonate In ethanol; water at 20 - 100℃; for 16h;100%
With potassium carbonate In ethanol; water at 100℃; for 16h; sealed tube;95%
4-Trifluoromethoxyphenol
828-27-3

4-Trifluoromethoxyphenol

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

1-nitro-2-[4 (trifluoromethoxy)phenoxy]benzene
23891-48-7

1-nitro-2-[4 (trifluoromethoxy)phenoxy]benzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 5h; Product distribution / selectivity; Heating / reflux;100%
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

4-fluoro-3-nitro-benzenesulfonic acid
3888-84-4

4-fluoro-3-nitro-benzenesulfonic acid

Conditions
ConditionsYield
With sulfuric acid at 60℃; for 0.5h;100%
With sulfuric acid; sulfur trioxide at 60℃; for 0.5h;
With chlorosulfonic acid at 80℃; for 10h;
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

(2S)-aminopentanoic acid tert-butyl ester hydrochloride

(2S)-aminopentanoic acid tert-butyl ester hydrochloride

(S)-2-(2-nitro-phenylamino)-pentanoic acid tert-butyl ester
1090903-13-1

(S)-2-(2-nitro-phenylamino)-pentanoic acid tert-butyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 70℃;100%
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Cyclopropylamine
765-30-0

Cyclopropylamine

cyclopropyl-(2-nitro-phenyl)-amine
55432-23-0

cyclopropyl-(2-nitro-phenyl)-amine

Conditions
ConditionsYield
With triethylamine In acetonitrile at 110℃;100%
In dimethyl sulfoxide at 20 - 80℃;100%
at 20℃; for 12h;90.3%

1493-27-2Relevant articles and documents

Method for synthesizing nitro (hetero) aromatic hydrocarbon

-

Paragraph 0082-0084; 0097-0099, (2022/04/08)

The invention discloses a method for synthesizing nitro (hetero) aromatic hydrocarbon, and belongs to the field of organic synthesis. According to the method, simple (hetero) aromatic hydrocarbon is taken as an initial raw material and is stirred and reacted in an organic solvent at 40-100 DEG C under the action of a nitration reagent, a lewis acid catalyst and protective gas, and nitro (hetero) aromatic hydrocarbon can be obtained. The method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple preparation process, good chemical selectivity, wide substrate application range, easy amplification and the like, has great application potential, and lays a good foundation for industrial production.

Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination

Xu, Peng,López-Rojas, Priscila,Ritter, Tobias

supporting information, p. 5349 - 5354 (2021/05/05)

Abundant aromatic carboxylic acids exist in great structural diversity from nature and synthesis. To date, the synthetically valuable decarboxylative functionalization of benzoic acids is realized mainly by transition-metal-catalyzed decarboxylative cross couplings. However, the high activation barrier for thermal decarboxylative carbometalation that often requires 140 °C reaction temperature limits both the substrate scope as well as the scope of suitable reactions that can sustain such conditions. Numerous reactions, for example, decarboxylative fluorination that is well developed for aliphatic carboxylic acids, are out of reach for the aromatic counterparts with current reaction chemistry. Here, we report a conceptually different approach through a low-barrier photoinduced ligand to metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation strategy, which generates a putative high-valent arylcopper(III) complex, from which versatile facile reductive eliminations can occur. We demonstrate the suitability of our new approach to address previously unrealized general decarboxylative fluorination of benzoic acids.

Low-temperature and highly efficient liquid-phase catalytic nitration of chlorobenzene with NO2: Remarkably improving the para-selectivity in O2-Ac2O-Hβ composite system

Deng, Renjie,Liu, Pingle,Luo, He'an,Ni, Wenjin,You, Kuiyi,Zhao, Fangfang

, (2020/02/26)

In this work, we developed a low-temperature and efficient approach for the highly selective preparation of valuable p-nitrochlorobenzene from the liquid-phase catalytic nitration of chlorobenzene with NO2 in O2-Ac2O-Hβ composite system. The results demonstrated that the introduction of molecular oxygen remarkably enhanced the chlorobenzene conversion and the cooperation catalysis of Hβ zeolite and Ac2O envidently improved the selectivity to para-nitro product. Under the optimized reaction conditions, 93.6 % of the selectivity to p-nitrochlorobenzene with 84.0 % of chlorobenzene conversion was obtained, and the ratio of p-nitrochlorobenzene to o-nitrochlorobenzene could reach up to 20.3. Furthermore, the selectivity distribution of nitration products was reasonably explained by the density functional theory (DFT) calculation. Finally, the possible nitration reaction pathway of chlorobenzene with NO2 was suggested in O2-Ac2O-Hβ composite catalytic system. The present work affords a new and mild nitration approach for highly selective preparation of valuable para-nitro products, and has potential industrial application prospects.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1493-27-2